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Sequential
gene expression profiling during treatment for identification of predictive
markers and novel therapeutic targets in chronic lymphocytic leukemia. M
Shehata, D Demirtas, S Schnabl, M Hilgarth, R Hubmann, C Fonatsch, I
Schwarzinger, G Hopfinger, K Eigenberger, D Heintel, E Porpaczy, K Vanura, A
Hauswirth, J D Schwarzmeier, A Gaiger, S Stilgenbauer, M Hallek, M Bilban and
U Jäger. Leukemia 2010 Oct 22. in press PMID:
20966934 Tauber S, Jais A, Jeitler M, Haider S, Husa J, Lindroos J,
Knöfler M, Mayerhofer M, Pehamberger H, Wagner O, Bilban M.
Transcriptome analysis of human cancer reveals a functional role of Heme
Oxygenase-1 in tumor cell adhesion. Molecular Cancer 2010, Jul 28;9:200. PMID: 20667089 Bilban M, Tauber S, Haslinger P, Pollheimer J, Saleh L, Pehamberger H,
Wagner O, Knöfler M. Trophoblast Invasion: Assessment Of Cellular Models
Using Gene Expression Signatures. Placenta 2010 Nov;31(11):989-96. PMID: 20850871 Bentz EK, Pils D,
Bilban M, Kaufmann U, Hefler LA, Reinthaller A, Singer CF, Huber JC, Horvat
R, Tempfer CB. Gene expression
signatures of breast tissue before and after cross-sex hormone therapy in
female-to-male transsexuals. Fertil Steril. 2010 May 25. [Epub ahead of
print] PMID: 20537635 Kubista B, Klinglmüller F, Bilban M, Pfeiffer M, Lass R, Giurea
A, Funovics PT, Toma C, Dominkus M, Kotz R, Thalhammer T, Trieb K, Zettl T,
Singer CF. Microarray analysis identifies distinct gene expression profiles
associated with histological subtype in human osteosarcoma. Int Orthop. 2010
Mar 26. [Epub ahead of print] PMID:
20340016 Ramadoss P, Chiappini F, Bilban M, Hollenberg AN. Regulation of
hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4)
expression by STAT3 and C/EBPalpha. J Biol Chem. 2010 May 28;285(22):16453-66
PMID: 20304921 Musteanu M, Blaas L, Mair M, Schlederer M, Bilban M, Tauber S,
Esterbauer H, Müller M, Casanova E, Kenner L, Poli V, Eferl R. Stat3 is
a negative regulator of intestinal tumor progression in ApcMin mice. Gastroenterology.
2010 Mar;138(3):1003-11.e1-5. PMID:
19962983 Mair M, Zollner G, Schneller D, Musteanu M, Fickert P, Gumhold J,
Schuster C, Fuchsbichler A, Bilban M, Tauber S, Esterbauer H, Kenner L, Poli
V, Blaas L, Kornfeld JW, Casanova E, Mikulits W, Trauner M, Eferl R. Stat3
Protects from Liver Injury and Fibrosis in a Mouse Model of Sclerosing
Cholangitis. Gastroenterology. 2010 Jun;138(7):2499-508. PMID: 20193684 Blüml S, Binder NB, Niederreiter B, Polzer K, Hayer S, Tauber S,
Schett G, Scheinecker C, Kollias G, Selzer E, Bilban M, Smolen JS,
Superti-Furga G, Redlich K. Anti-inflammatory effects of TNF on hematopoietic
cells in the development of erosive arthritis. Arthritis Rheum. 2010
Jun;62(6):1608-19. PMID: 20155834 Hudelist G, Huber A, Auer M, Knöfler M, Saleh L, Hrachowitz C,
Huber JC, Kubista E, Manavi M, Bilban M, Singer CF. Administration of betaHCG
leads to dose-dependent changes of gene expression signature of endometriotic
stromal cells. Reprod Biomed Online. 2010 May;20(5):699-706. PMID: 20395176 Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M,
de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler M.
Nrf2 regulates the stress response to UVA – oxidized phospholipids in
skin cells. FASEB J 2010 Jan;24(1):39-48. PMID:
19720622 Schweighofer B, Testori J, Sturtzel C, Mayer H, Wagner O, Bilban M,
and Hofer E. The VEGF-induced transcriptional response comprises gene
clusters at the crossroad of angiogenesis and inflammation. Thrombosis and
Haemostasis. 2009;102(3):544-54. PMID:
19718476 Porpaczy E, Bilban M, Heinze G, Gruber M,
Vanura K, Schwarzinger I, Stilgenbauer S, Streubel B, Fonatsch C, Jäger
U. Gene Expression Signature of Chronic Lymphocytic Leukemia with Trisomy 12.
Eur J Clin Invest. 2009 Apr 30; PMID: 19453646 Karayel E, Bürckstümmer T, Bilban M, Dürnberger G,
Weitzer S, Martinez J, Superti-Furga G. The TLR-independent DNA recognition
pathway in murine macrophages: Ligand features and molecular signature. Eur J
Immunol. 2009 Jul;39(7):1929-36. PMID:
19551900 Zatkova A, Merk S, Wendehack M, Bilban M, Muzik EM, Muradyan A,
Haferlach C, Haferlach T, Wimmer K, Fonatsch C, Ullmann R. AML/MDS with
11q/MLL amplification show characteristic gene expression signature and
interplay of DNA copy number changes. Genes Chromosomes Cancer. 2009 Mar 20.
[Epub ahead of print] PMID: 19306356 Bürckstümmer T, Baumann C, Blüml S, Dixit E,
Dürnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL,
Superti-Furga G.An orthogonal proteomic-genomic screen identifies AIM2 as a
cytoplasmic DNA sensor for the inflammasome. Nat Immunol. 2009 Jan 21; PMID: 19158679 Bilban M, Haslinger P, Prast J, Klinglmüller F, Woelfel T, Haider
S, Sachs A, Otterbein LE, Desoye G, Hiden U, Wagner O, Knöfler M.
Identification of novel trophoblast invasion-related genes: Heme oxygenase-1
controls motility via PPARγ.
Endocrinology Feb;150(2):1000-13; PMID:
18845641 Astapova I, Lee LJ, Morales C, Tauber S, Bilban M, Hollenberg AN. The
Nuclear CoRepressor, NCoR, Regulates Thyroid Hormone Action in vivo. Proc
Natl Acad Sci U S A. 2008 Dec 9;105(49):19544-9; PMID: 19052228 Wick N, Haluza D, Gurnhofer E, Raab I, Kasimir MT, Prinz M, Steiner
CW, Reinisch C, Howorka A, Giovanoli P, Buchsbaum S, Krieger S, Tschachler E,
Petzelbauer P, Kerjaschki D. Lymphatic precollectors contain a novel,
specialized subpopulation of podoplanin low, CCL27-expressing lymphatic
endothelial cells. Am J Pathol. 2008 Oct;173(4):1202-9. PMID: 18772332 Hantschel O, Gstoettenbauer A, Colinge J, Kaupe I, Bilban M, Burkard
TR, Valent P, Superti-Furga G. The chemokine IL-8 and the surface activation
protein CD69 are markers for Bcr-Abl activity in CML. Mol Oncol. 2008
Oct;2(3):272-81. PMID: 19383348 Lang I, Schweizer A, Hiden U, Ghaffari-Tabrizi N, Hagendorfer G,
Bilban M, Pabst MA, Korgun ET, Dohr G, Desoye G. Human fetal placental
endothelial cells have a mature arterial and a juvenile venous phenotype with
adipogenic and osteogenic differentiation potential. Differentiation. 2008
Jul 30. [Epub ahead of print] PMID:
18673379 Mayerhofer M, Gleixner KV, Hoelbl A, Florian S, Hoermann G, Aichberger
K, Bilban M, Esterbauer H, Krauth MT, Sperr W, Longley J, Kralovics R,
Moriggl R, Zappulla J, Liblau RS, Schwarzinger I, Sexl V, Sillaber C, Valent
P. Unique effects of KIT D816V in Ba/F3 cells: induction of cluster
formation, histamine synthesis, and early mast cell differentiation antigens.
J Immunology, 2008; 2008 Apr 15;180(8):5466-76. PMID: 18390729 Heller G, Schmidt WM, Ziegler B, Holzer S, Müllauer L, Bilban M,
Zielinski CC, Drach J, Zöchbauer-Müller S. Genome-wide
transcriptional response to 5-aza-2’-deoxycytidine and Trichostatine A
in multiple myeloma cells. Cancer Research. 2008; 68(1):44-54. PMID: 18172295 Schmidt WM, Spiel AO, Jilma B, Wolzt M, Müller M. In-vivo effects
of simvastatin and rosuvastatin on global gene expression in peripheral blood
leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008
Feb;18(2):109-20. PMID: 18192897 Hiden U, Wadsack C, Prutsch N, Gauster M, Weiss U, Frank HG, Schmitz
U, Fast-Hirsch C, Hengstschlager M, Potgens A, Ruben A, Knöfler M,
Haslinger P, Huppertz B, Bilban M, Kaufmann P, Desoye G. The first trimester
human trophoblast cell line ACH-3P: A novel tool to study autocrine/paracrine
regulatory loops of human trophoblast subpopulations - TNF lpha stimulates
MMP15 expression. BMC Dev Biol. 2007; 7(1):137. PMID: 18093301 Bilban M, Haschemi A, Wegiel B, Chin BY, Wagner O, Otterbein LE. Heme
Oxygenase and carbon monoxide initiate homeostatic signalling. J Molecular
Medicine. 2008 Mar;86(3):267-79. PMID:
18034222 Nabokikh A, Ilhan A, Bilban M, Gartner W, Vila G, Niederle B, Nielsen
JH, Wagner O, Base W, Luger A, Wagner L. Reduced TGF-ß1 expression and
its target genes in human insulinomas. Exp & Clin Endocrinology &
Diabetes. 2007; 115(10):674-82. PMID:
18058603 Kainz B, Shehata M, Bilban M, Kienle D, Heintel D,
Krömer-Holzinger E, Le T, Kröber A, Heller G, Schwarzinger I,
Demirtas D, Chott A, Döhner H, Zöchbauer-Müller S, Fonatsch C,
Zielinski C, Stilgenbauer S, Gaiger A, Wagner O, Jäger U. Overexpression
of the paternally expressed gene 10 (PEG10) from the imprinted locus on
chromosome 7q21 in high-risk B-cell chronic lymphocytic leukaemia. Int J
Cancer. 2007; 121(9):1984-93. PMID:
17621626 Schweighofer B, Schultes J, Pomyje J, Hofer E. Signals and genes
induced by angiogenic growth factors in comparison to inflammatory cytokines
in endothelial cells. Clin Hemorheol Microcirc. 2007;37(1-2):57-62. PMID: 17641395 Huber A, Hudelist G, Knöfler M, Saleh L, Huber JC, Singer CF. Effect
of highly purified human chorionic gonadotropin preparations on the gene
expression signature of stromal cells derived from endometriotic lesions:
potential mechanisms for the therapeutic effect of human chorionic
gonadotropin in vivo. Fertil Steril. 2007; 88(4 Suppl):1232-9. PMID: 17561010 Wick N, Saharinen P, Saharinen J, Gurnhofer E, Steiner CW, Raab I,
Stokic D, Giovanoli P, Buchsbaum S, Burchard A, Thurner S, Alitalo K,
Kerjaschki D. Transcriptomal comparison of human dermal lymphatic endothelial
cells ex vivo and in vitro. Physiol Genomics. 2007; 28(2):179-92. PMID: 17234558 Löwe R, Valero T, Kremling S, Pratscher B, Kunstfeld R,
Pehamberger H, Petzelbauer P. Dimethylfumarate impairs melanoma growth and
metastasis. Cancer Res. 2006; 66(24):11888-96. PMID: 17178886 Huber J, Löffler M, Bilban M, Reimers M, Kadl A, Todoric J, Zeyda
M, Geyeregger R, Schreiner M, Weichart T, Leitinger N, Waldhäusl W,
Stulnig TM. Prevention of high-fat diet-induced adipose tissue remodeling in
obese diabetic mice by n-3 polyunsaturated fatty acids. International Journal
of Obesity. 2007; 31(6):1004-13. PMID:
17130847 Aichberger KJ, Mayerhofer M, Vales A, Krauth MT, Gleixner KV, Bilban
M, Esterbauer H, Sonneck K, Florian S, Derdak S, Pickl WF, Agis H, Falus A,
Sillaber C, Valent P. The CML-related oncoprotein BCR/ABL induces expression
of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic
cells. Blood. 2006; 108(10):3538-47. PMID:
16849647 Bilban M, Bach FH, Otterbein SL, Ifedigbo E, de Costa d'Avila J,
Esterbauer H, Chin BY, Usheva A, Robson SC, Wagner O, Otterbein LE. Carbon
monoxide orchestrates a protective response through PPAR. Immunity. 2006; 24(5):601-10. PMID:
16713977 Lucerna M, Pomyje J, Mechtcheriakova D, Kadl A, Gruber F, Bilban M,
Sobanov Y, Schabbauer G, Breuss J, Wagner O, Bischoff M, Clauss M, Binder B,
Hofer E. Sustained expression of EGR-1 blocks angiogenesis and tumor growth. Cancer
Research. 2006; 66(13):6708-6713. PMID:
16818645 Todoric J, Loffler M, Huber J, Bilban M, Reimers M, Kadl A, Zeyda M,
Waldhausl W, Stulnig TM. Adipose tissue inflammation induced by high-fat diet
in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids. Diabetologia.
2006; 49(9):2109-19. PMID: 16783472 Bilban M, Heintel D, Scharl T, Wölfel T,
Auer MM, Porpaczy E, Kainz B, Krober A, Carey VJ, Shehata M, Zielinski C,
Pickl W, Stilgenbauer S, Gaiger A, Wagner O, Jäger U; German CLL Study
Group. Deregulated expression of fat and muscle genes in B-cell chronic
lymphocytic leukemia with high lipoprotein lipase expression. Leukemia. 2006;
20(6):1080-8. PMID: 16617321
Löffler M, Bilban M, Reimers M, Waldhausl W, Stulnig TM. Blood
glucose-lowering nuclear receptor agonists only partially normalize hepatic
gene expression in db/db mice. J Pharmacol Exp Ther. 2006; 316(2):797-804. PMID: 16260581 Altenberger T, Bilban M, Auer M, Knosp E, Wolfsberger S, Gartner W,
Mineva I, Zielinski C, Wagner L, Luger A. Identification of DLK1 variants in
pituitary- and neuroendocrine tumors. Biochem Biophys Res Commun. 2006;
340(3):995-1005. PMID: 16403460 Hiden U, Maier A, Bilban M, Ghaffari-Tabrizi N, Wadsack C, Lang I,
Dohr G, Desoye G. Insulin control of placental gene expression shifts from
mother to foetus over the course of pregnancy. Diabetologia. 2006;
49(1):123-31. PMID: 16344925 Horak P, Pils D, Haller G, Pribill I, Roessler M, Tomek S, Horvat R,
Zeillinger R, Zielinski C, Krainer M. Contribution of epigenetic silencing of
tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to
TRAIL resistance and ovarian cancer. Mol Cancer Res. 2005; 3(6):335-43. PMID: 15972852 Okamoto I, Pirker C, Bilban M, Berger W, Marosi C, Haas OA, Wolff K,
Pehamberger H. Seven novel and stable translocations associated with
oncogenic gene expression in malignant melanoma. Neoplasia. 2005; 7(4):303-11.
PMID: 15967107 Bilban M, Ghaffari N, Hintermann E, Bauer S, Molzer S, Zoratti C,
Malli R, Sharabi A, Graier W, Knoefler M, Andreae F, Wagner O, Quaranta V,
Desoye G. Kisspeptin-10, a KiSS1/metastin-derived dekapeptide, is a
physiologic invasion inhibitor of primary human trophoblast. J Cell Sci.
2004; 117(Pt 8):1319-28. PMID: 15020672 Mayer H, Bilban M, Kurtev V, Gruber F, Wagner O, Binder BR, de Martin
R. Deciphering Regulatory Patterns of Inflammatory Gene Expression from
Interleukin 1 - Stimulated Human Endothelial Cells. Arteriosclerosis
Thrombosis and Vascular Biology. 2004. 24:1-8. PMID: 15130917 Wick N, Bruck J, Gurnhofer E, Steiner CW, Giovanoli P, Kerjaschki D,
Thurner S. Nonuniform hybridization: a potential source of error in
oligonucleotide-chip experiments with low amounts of starting material. Diagn
Mol Pathol. 2004; 13(3):151-9. PMID:
15322426 Schenk S, Hintermann E, Koshikawa N, Bilban M, Khokha R, Quaranta V.
Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent
mammary gland involution. Journal of Cell Biology. 2003 161(1): 197-209. PMID: 12695504 Bilban M, Bühler LK, Head S, Desoye G, Quaranta V. Defining
signal thresholds in DNA microarrays: exemplary application for invasive
cancer. BMC Genomics 2002; 3:19. PMID:
12123529 Bilban M, Bühler LK, Head S, Desoye G, Quaranta V. Normalizing
DNA microarray data. Current Issues in Molecular Biology 2002; (4): 57-64. PMID: 11931570 Bilban M, Head S, Desoye G, Quaranta V. DNA microarrays: a novel
approach to investigate genomics in trophoblast invasion--a review. Placenta. 2000; 21
Suppl A:S99-105. Review. PMID: 10831133 |
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