In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalyzing their conjugation to glutathione [1]. The C-terminal GST domain is also found in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1 and the HSP26 family of stress-related proteins. Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism. GSTs are composed of an N-terminal domain, which adopts the thioredoxin fold, and a C-terminal all-helical domain.
Allergenic members of this family include allergens from mites (group 8) [2], cockroaches (group 5), and fungi.
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