- Pfam domains
- PF00061: Lipocalin / cytosolic fatty-acid binding protein family
- pf08212: Lipocalin-like domain
Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids . The family also contains the enzyme prostaglandin D synthase. Lipocalins fold into an eight-stranded anti-parallel β-barrel.
Allergens from this protein family include:
- β-Lactoglobulins: β-Lactoglobulin is the major whey protein of ruminant species . Bos d 5 is a major cow's mlk allergen . Cross-reactions to milk proteins from other species were also described .
- Mammalian dander allergens: Lipocalins constitue the vast majority of mammalian dander allergens . Examples are Can f 1 and Can f 2 from dog, Fel d 4 from cat, and Bos d 2 from cattle.
- Cytoplasmic fatty acid binding proteins: The proteins are distantly related to extracellular lipocalins and β-lactoglubulins. They were identified as minor allergens in mites (group 13) and cockroaches .
Lipocalins - a family portrait.
J Plant Physiol 2006, 163, 895-915. [PubMed]
Invited review: beta-lactoglobulin: binding properties, structure, and function.
J Dairy Sci 2004, 87, 785-96. [PubMed]
Bovine milk allergenicity.
Ann Allergy Asthma Immunol 2004, 93, S2-11. [PubMed]
Cross-reactivity between milk proteins from different animal species.
Clin Exp Allergy 1999, 29, 997-1004. [PubMed]
The role and remediation of animal allergens in allergic diseases.
J Allergy Clin Immunol 2001, 107, S414-21. [PubMed]
Characterization and immunobiology of house dust mite allergens.
Int Arch Allergy Immunol 2002, 129, 1-18. [PubMed]
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