AF018: Serpin serine protease inhibitor
- Pfam domains
- PF00079: Serpin (serine protease inhibitor)
Serpins are irreversible serine protease inhibitors active against S1, S8 and C14 peptidases . Their common structure is a multi-domain fold containing a bundle of 8 or 9 α-helices and a β-sandwich formed by 3 β-sheets.
Allergens from this family include hen's egg ovalbumin (Gal d 2) and Z4 from barley, a protein causing allergic reactions to beer [2, 3].
An overview of the serpin superfamily.
Genome Biol 2006, 7, 216. [PubMed]
Comparative studies on antigenicity and allergenicity of native and denatured egg white proteins.
J Agric Food Chem 2002, 50, 2679-83. [PubMed]
Isolation and characterization of barley lipid transfer protein and protein Z as beer allergens.
J Allergy Clin Immunol 2001, 108, 647-9. [PubMed]
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