AllFam - Database of allergen families Department of Pathophysiology and Allergy Research Medical University of Vienna

AF020: Fe/Mn superoxide dismutase

Pfam domains
PF00081: Iron/manganese superoxide dismutases, alpha-hairpin domain
PF02777: Iron/manganese superoxide dismutases, C-terminal domain

Biochemical properties

The function of the members of this protein family is to destroy the radicals that are normally produced within cells and are toxic to biological systems by catalysing the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one.

Allergological significance

Mn-binding superoxide dismutases from plants and fungi were identified as cross-reactive allergens [1, 2].

References

  1. Wagner S, Sowka S, Mayer C, Crameri R, Focke M, Kurup VP, Scheiner O, Breiteneder H.
    Identification of a Hevea brasiliensis latex manganese superoxide dismutase (Hev b 10) as a cross-reactive allergen.
    Int Arch Allergy Immunol 2001, 125, 120-7. [PubMed]
  2. Fluckiger S, Scapozza L, Mayer C, Blaser K, Folkers G, Crameri R.
    Immunological and structural analysis of IgE-mediated cross-reactivity between manganese superoxide dismutases.
    Int Arch Allergy Immunol 2002, 128, 292-303. [PubMed]

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