A number of eukaryotic extracellular proteins have been shown to be evolutionarily related. The family includes rodent sperm-coating glycoprotein, which is thought to be involved in sperm maturation, mammalian testis-specific protein (Tpx-1), mammalian cysteine rich secretory proteins (CRISP), glioma pathogenesis-related protein, reptile toxins, insect venom allergens, and plant pathogenesis-related proteins PR-1. These proteins have been proposed to be Ca2+ chelating serine protease [1].
Most allergens from this family are insect venom allergens including group 5 vasp allergens and group 3 ant allergens [2]. Allergens from the plant PR-1 family include the Bermuda grass pollen allergen Cyn d 24, the mugwot pollen allergen Art v 2 and the muskmelon allergen, Cuc m 3.
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