A number of eukaryotic extracellular proteins have been shown to be evolutionarily related. The family includes rodent sperm-coating glycoprotein, which is thought to be involved in sperm maturation, mammalian testis-specific protein (Tpx-1), mammalian cysteine rich secretory proteins (CRISP), glioma pathogenesis-related protein, reptile toxins, insect venom allergens, and plant pathogenesis-related proteins PR-1. These proteins have been proposed to be Ca2+ chelating serine protease .
Most allergens from this family are insect venom allergens including group 5 vasp allergens and group 3 ant allergens . Allergens from the plant PR-1 family include the Bermuda grass pollen allergen Cyn d 24, the mugwot pollen allergen Art v 2 and the muskmelon allergen, Cuc m 3.
If you have updates or corrections for this entry, please contact the site administrator.