AllFam - Database of allergen families Department of Pathophysiology and Allergy Research Medical University of Vienna

AF075: SGNH-hydrolase family

Pfam domains
PF00657: GDSL-like Lipase/Acylhydrolase

Biochemical properties

This family includes several lipolytic enzymes with serine as part of the active site, which show a diverse range of activities such as lipase, arylesterase, carbohydrate esterase, and phospholipase [1].

Allergological significance

Hev b 4, a glycoallergen from Hevea brasiliensis latex is a lecithinase [2]. IgE binding to this allergens is directed exclusively to its glycan moieties. A second latex allergen from this protein family, Hev b 13, is also a glycoprotein [3].

References

  1. Molgaard A, Kauppinen S, Larsen S.
    Rhamnogalacturonan acetylesterase elucidates the structure and function of a new family of hydrolases.
    Structure 2000, 8, 373-83. [PubMed]
  2. Sunderasan E, Bahari A, Arif SA, Zainal Z, Hamilton RG, Yeang HY.
    Molecular cloning and immunoglobulin E reactivity of a natural rubber latex lecithinase homologue, the major allergenic component of Hev b 4.
    Clin Exp Allergy 2005, 35, 1490-5. [PubMed]
  3. Arif SA, Hamilton RG, Yusof F, Chew NP, Loke YH, Nimkar S, Beintema JJ, Yeang HY.
    Isolation and characterization of the early nodule-specific protein homologue (Hev b 13), an allergenic lipolytic esterase from Hevea brasiliensis latex.
    J Biol Chem 2004, 279, 23933-41. [PubMed]

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