AllFam - Database of allergen families Department of Pathophysiology and Allergy Research Medical University of Vienna

AF085: Kappa-casein

Pfam domains
PF00997: Kappa casein

Biochemical properties

The specific cleavage of κ-casein by chymosin is the first step in the milk clotting process. Chymosin proteolytically cuts and inactivates κ-casein, converting it into an insoluble peptide (para κ-casein) and a soluble hydrophilic glycopeptide called casein macropeptide [1].

Allergological significance

Allergenic members of this family include milk allergens from cow, sheep and goat [2].

References

  1. Visser S, Van Rooijen PJ, Slangen CJ.
    Peptide substrates for chymosin (rennin). Isolation and substrate behaviour of two tryptic fragments of bovine kappa casein.
    Eur J Biochem 1980, 108, 415-21. [PubMed]
  2. Roncada P, Gaviraghi A, Liberatori S, Canas B, Bini L, Greppi GF.
    Identification of caseins in goat milk.
    Proteomics 2002, 2, 723-6. [PubMed]

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