AllFam - Database of allergen families Department of Pathophysiology and Allergy Research Medical University of Vienna

AF089: Lipid-binding serum glycoprotein

Pfam domains
PF01273: LBP / BPI / CETP family, N-terminal domain

Biochemical properties

A number of mammalian lipid-binding serum glycoproteins belong to this family. They include the lipopolysaccharide-binding protein (LBP), the bactericidal permeability-increasing protein (BPI), the cholesteryl ester transfer protein (CETP) and the phospholipid transfer protein (PLTP).

Allergological significance

The horse dander allergens Equ c 4 and Equ c 5 are latherins, a surfactant protein in sweat [1, 2].

References

  1. Beeley JG, Eason R, Snow DH.
    Isolation and characterization of latherin, a surface-active protein from horse sweat.
    Biochem J 1986, 235, 645-50. [PubMed]
  2. Goubran Botros H, Poncet P, Rabillon J, Fontaine T, Laval JM, David B.
    Biochemical characterization and surfactant properties of horse allergens.
    Eur J Biochem 2001, 268, 3126-36. [PubMed]

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