AllFam - Database of allergen families Department of Pathophysiology and Allergy Research Medical University of Vienna

AF109: Fungalysin metalloprotease

Pfam domains
PF02128: Fungalysin metallopeptidase (M36)
PF07504: Fungalysin/Thermolysin Propeptide Motif

Biochemical properties

Fungalysin is produced by Aspergillus and other fungal species [1]. It aids in degradation of host lung cell walls on infection.

Allergological significance

Asp f 5 is a major allergen from Aspergillus fumigatus [2].

References

  1. Xu J, Baldwin D, Kindrachuk C, Hegedus DD.
    Serine proteases and metalloproteases associated with pathogenesis but not host specificity in the Entomophthoralean fungus Zoophthora radicans.
    Can J Microbiol 2006, 52, 550-9. [PubMed]
  2. Crameri R.
    Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications.
    Int Arch Allergy Immunol 1998, 115, 99-114. [PubMed]

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