The MD-2-related lipid recognition domain (ML domain) is found in proteins from plants, animals and fungi. It has been implicated in lipid recognition, particularly in the recognition of pathogen-related products. A member of this family is MD-2, an extracellular protein that binds lipopolysaccharide and induces the innate immune response by binding to Toll-like receptor 4 .
Group 2 mite allergens are major and partially cross-reactive allergens identified in a large number of mite species . Der p 2 from Dermatophagoides pteronyssinus was shown to mimic the biological function of MD-2 , which may explain its allergenic activity.
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