AllFam - Database of allergen families Department of Pathophysiology and Allergy Research Medical University of Vienna

AF127: Group 1 cockroach allergen

Pfam domains
PF06757: Insect allergen related repeat, nitrile-specifier detoxification

Biochemical properties

This family consists of several insect specific allergen repeats. Members of this family are commonly found in cockroaches, fruit flies and mosquitos. It has been suggested that the repeat sequences have evolved by duplication of an ancestral amino acid domain, which may have arisen from the mitochondrial energy transfer proteins [1].

Allergological significance

Bla g 1 and Per a 1 are major, cross-reactive allergens from German and American cockroach, respectively [1].

References

  1. Pomes A, Melen E, Vailes LD, Retief JD, Arruda LK, Chapman MD.
    Novel allergen structures with tandem amino acid repeats derived from German and American cockroach.
    J Biol Chem 1998, 273, 30801-7. [PubMed]

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