Aconitase (aconitate hydratase) is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle. The enzyme conains an iron-sulfur cluster in its active center. Other members of this family are the iron-responsive element-binding protein (IRE-BP), an mRNA-binding protein involved in the regulation of iron metabolism, and 3-isopropylmalate dehydratase, an enzyme catalysing the second step in the biosynthesis of leucine.
A 3-isopropylmalate dehydratase from the mould Aspergillus fumigatus was identified as IgE binding by 2-D-PAGE [1].
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