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Last five years | All
2009 2008 2007 2006 | 2009 Original Articles | | o | Helbig I, Rosenow F, Urak L, Fuchs K, Feucht M, Franke A, Muhle H, Baker C, Klein KM, Wittig M, Nothnagel M, Schreiber S, Eichler EE, Sander T (2009) 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy Nature Genetics, 41(2): 160-162 | | o | Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM (2009) Antiseizure activity of novel gamma-aminobutyric acid(A) receptor subtype-selective benzodiazepine analogues in mice and rat models J Med Chem, 52: 1795-1798 | | o | Tong J, Wong H, Guttman M, Ang L, Forno L, Shimadzu M, Rajput A, Muenter M, Kish S, Hornykiewicz O, Furukawa Y (2009) Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson´s disease and progressive supranuclear palsy: a comparative investigation Brain, : in Press | | o | Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Pifl C, Penninger J et al (2009) Central control of fever and female body temperature by RANKL/RANK Nature, 462: 505-509 | | o | Boileau I, Guttman M, Rusjan P, Adams JR, Houle S, Tong J, Hornykiewicz O, Furukawa Y, Wilson AA, Kapur S, Kish SJ (2009) Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson´s disease Brain, 132: 1366-1375 | | | Article (PDF) | | | | o | Tretter V, Revilla-Sanchez R, Houston C, Terunuma M, Havekes R, Florian C, Jurd R, Vithlani M, Michels G, Couve A, Sieghart W, Brandon N, Abel T, Smart T, Moss S (2009) Deficits in spatial memory correlate with modified y-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus Proc Natl Acad Sci USA, : In Press | | o | Kang SU, Fuchs K, Sieghart W, Pollak A, Csaszar E, Lubec G (2009) Gel-based mass spectrometric analysis of a strongly hydrophobic GABAA-receptor subunit containing four transmembrane domains Nat. Protoc., 4: 1093-1102 | | o | Samadi P, Rajput A, Calon F, Gregoire L, Hornykiewicz O, Rajput AH, Di Paolo T (2009) Metabotropic glutamate receptor II in the brains of Parkinsonian patients J Neuropath Exp Neurol, 68: 374-382 | | | Article (PDF) | | | | o | Marchionni I, Kasap Z, Mozrzymas JW, Sieghart W, Cherubini E, Zacchi P (2009) New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibitition in rat hippocampal neurons in culture Neuroscience, 164(2): 552 - 562 | | o | Berger M.L, Schweifer A, Rebernik P, Hammerschmidt F (2009) NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds Bioorg Med Chem, 17: 3456-3462 | | | Article (PDF) | | | | o | de Kovel CGF, Trucks H, Helbig I, Rosenow F, Zimprich F, Urak L, Feucht M, Fuchs K, Schreiber S, Nürnberg P, Eichler E, Sander T (2009) Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies Brain, : in Press | | o | Atucha E, Hammerschmidt F, Zolle I, Sieghart W, Berger ML (2009) Structure-activity relationship of etomidate derivatives at the GABA-A receptor: Comparison with binding to 11-beta-hydroxylase Bioorg Med Chem Lett, 19: 4284-4287 | | o | Nicolussi EM, Huck S, Lassmann H, Bradl M (2009) The cholinergic anti-inflammatory system limited T cell infiltration into the neurodegenerative CNS, but can not counteract complex CNS inflammation Neurobiol Dis, 35: 24-31 | | o | Pifl C, Wolf A, Rebernik P, Reither H, Berger M L (2009) Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner Neuropharmacology, 56: 531-540 | | | Article (PDF) | | | | 2009 Reviews | | o | Olsen RW, Sieghart W (2009) Subtypes provide diversity of function and pharmacology Neuropharmacology, 56: 141-148 | | 2008 Original Articles | | o | Furtmüller R, Furtmüller B, Ramerstorfer J, Paladini AC, Wasowski C, Marder M, Huck S, Sieghart W (2008) 6,3'-Dinitroflavone is a low efficacymodulator of GABA(A) receptors Eur. J. Pharmacol., 591: 142-146 | | o | Han D, Försterling FH, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmüller R, Rowlett J, Weed MR, Cook JM (2008) A study of the structure-activity relationship of GABA-A-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis Bioorg Med Chem, 16: 8853-8862 | | | Article (PDF) | | | | o | Payne HL, Ives JH, Sieghart W, Thompson CL (2008) AMPA and kainate receptors mediate mutually exclusive effects on GABA-A receptor expression in cultured mouse cerebellar granule neurons J Neurochem, 104: 173-186 | | | Article (PDF) | | | | o | Savic MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradovic DI, Ugresic ND, Sieghart W, Bokonjic DR, Cook JM (2008) Are GABA(A) Receptors Containing alpha5 Subunits Contributing to the Sedative Properties of Benzodiazepine Site Agonists? Neuropsychopharm, 33: 332-339 | | | Article (PDF) | | | | o | Terunuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ (2008) Deficits in phosphorylation of GABA-A receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus J Neurosci, 28: 376-384 | | | Article (PDF) | | | | o | Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S (2008) Estimating the efficiency of benzodiazepines on GABA-A receptors comprising gamma1 or gamma2 subunits Br. J. Pharmacol., 155: 424-433 | | o | Tretter V, Moss SJ (2008) GABA-A receptor dynamics and constructing inhibitory synapses Front Mol Neurosci, 1: 7 | | o | Kang SU, Fuchs K, Sieghart W, Lubec G (2008) Gel-based mass spectrometric analysis of recombinant GABA-A receptor subunits representing strongly hydrophobic transmembrane proteins J Proteome Res, 7: 3498-3506 | | | Article (PDF) | | | | o | Rajput A.H., Sitte H.H., Rajput A., Fenton M.E., Pifl C., Hornykiewicz O. (2008) Globus pallidus dopamine and Parkinson motor subtypes. Neurology, 70: 1403-1410 | | o | Schosser A, Fuchs K, Scharl T, Schloegelhofer M, Kindler J, Mossahe N, Kaufmann RM, Leisch F, Kasper S, Sieghart W, Aschauer HN (2008) Interaction between Serotonin 5-HT2A receptor gene and Dopamine Transporter (DAT1) gene polymorphisms influences personality trait of Persistence in Austrian Caucasians World J. Biol. Psychiat., Feb. 13: 1-8 | | o | Zolle I.M., Berger M.L., Hammerschmidt F., Hahner S., Schirbel A., Peric-Simov B. (2008) New Selective Inhibitors of Steroid 11ß-Hydroxylation in the Adrenal Cortex. Synthesis and Structure–Activity Relationship of Potent Etomidate Analogues J Med Chem, 51: 2244-2253 | | | Article (PDF) | | | | o | Putz G, Kristufek D, Orr-Urtreger A, Changeux JP, Huck S, Scholze P (2008) Nicotinic acetylcholine receptor-subunit mRNAs in the mouse superior cervical ganglion are regulated by development but not by deletion of distinct subunit genes J Neurosci Res, 86: 972-981 | | | Article (PDF) | | | | o | Kish SJ, Tong J, Hornykiewicz O, Rajput A, Chang LJ, Guttman M, Furukawa Y (2008) Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease Brain, 131: 120-131 | | o | Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HMB, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO (2008) Protein kinase C-delta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current J Neurosci, 28: 11890-11899 | | o | Savic MM, Clayton T, Furtmüller R, Gavrilovic I, Samardzic J, Savic S, Huck S, Sieghart W, Cook JM (2008) PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA-A receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats Brain Res., 1208: 150-159 | | o | Kittler JT, Chen G, Kukhtina V, Vahedi-Faridi A, Tretter V, Smith K, McAinsh K, Arancibia-Carcamo L, Sänger W, Hauke V, Yan Z, Moss SJ (2008) Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABA-A receptor gamma-2 subunit Proc Natl Acad Sci USA, 105(9): 3616-3621 | | o | Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, and DeLorey TM (2008) Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit J Med Chem, 51: 3788-3803 | | | Article (PDF) | | | | o | Tretter V, Jacob T, Mukherjee J, Fritschy JM, Pangalos M, Moss SJ (2008) The clustering of GABA(A) receptor subtypes at inhibitory synapses is faciliated via the direct binding of receptor alpha 2 subunits to gephyrin J Neurosci, 28(6): 1356-1365 | | 2008 Reviews | | o | Sarto-Jackson I, Sieghart W (2008) Assembly of GABA-A receptors Mol Membr Biol, 25: 302-310 | | | Article (PDF) | | | | o | Olsen RW, Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology and function - update Pharmacol Rev, 60: 243-260 | | | Article (PDF) | | | | 2008 Book Chapters | | o | Nanoff C, Pifl C (2008) Neurotransmitter transporters. In: (Eds.), Encyclopedia of Molecular Pharmacology Springer Berlin Heidelberg: 836-842 | | 2007 Original Articles | | o | Pytel M, Wojtowicz T, Mercik K, Sarto-Jackson I, Sieghart W, Ikonomidou C, Mozrzymas JW (2007) 17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro Neuropharmacology, 52: 1342-1353 | | | Article (PDF) | | | | o | Schosser A, Fuchs K, Scharl T, Leisch F, Bailer U, Kasper S, Sieghart W, Hornik K, Aschauer HN (2007) Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29 Eur Neuropsychopharm, 17: 501-505 | | | Article (PDF) | | | | o | Scholze P., Orr-Urtreger A., Changeux J.-P., McIntosh J.M. , Huck S (2007) Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation Br. J. Pharmacol., 151: 414-422 | | | Article (PDF) | | | | o | Wulff P, Goetz T, Leppä E, Linden AM, Renzi M, Swinny JD, Vekovischeva OY, Sieghart W, Somogyi P, Korpi ER, Farrant M, Wisden W (2007) From synapse to behaviour: rapid modulation of defined neuronal populations through engineered GABA-A receptors Nature Neurosci, 10: 923-929 | | | Article (PDF) | | | | o | Payne HL, Connelly WM, Ives JH, Lehner R, Furtmüller B, Sieghart W, Tiwari P, Lucocq JM, Lees G, Thompson CL (2007) GABA-A alpha6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer. J Biol Chem, 282: 29130-29143 | | | Article (PDF) | | | | o | Tong J, Hornykiewicz O, Furukawa Y, Kish SJ (2007) Marked dissociation between high noradrenaline vs. low noradrenaline transporter levels in human nucleus accumbens J Neurochem, 102: 1691-1702 | | o | Tretter V, Moss SJ (2007) Neurosteroid interactions with the GABA-A receptor Cell Sci Rev, 3: 4 | | o | Pöhler T., Schadt O., Niepel D., Rebernik P., Berger M.L., Noe C.R. (2007) New polyamine-sensitive inhibitors of the NMDA receptor: Syntheses and pharmacological evaluation. Eur J Med Chem, 42: 175-197 | | | Article (PDF) | | | | o | Tan KR, Gonthier A, Baur R, Ernst M, Goeldner M, Sigel E (2007) Proximity-Accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators J Biol Chem, 282: 26316-26325 | | o | Sarto-Jackson I, Furtmüller R, Ernst M, Huck S, Sieghart W (2007) Spontaneous cross-link of mutated alpha1 subunits during GABA-A receptor assembly J Biol Chem, 282: 4354-4363 | | | Article (PDF) | | | | 2007 Reviews | | o | Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM (2007) An updated unified pharmacophore model of the benzodiazepine binding site of gamma-aminobutyric acid(a) receptors: correlation with comparative models Current Topics in Medicinal Chemistry, 14: 2755-2775 | | | Article (PDF) | | | | 2007 Book Chapters | | o | Sieghart W (2007) Neurobiologische Grundlagen psychischer Erkrankungen. In: (Eds.), Krankheit, Krankheitsursachen und -bilder Marian B, Facultas Universitätsverlag: 380-384 | | o | Sieghart W (2007) Subunit Composition and Structure of GABA-A receptor subtypes. In: (Eds.), The GABA Receptors, 3rd edition (Enna SJ, Möhler H) Humana Press Inc.: | | 2006 Original Articles | | o | Urak L, Feucht M, Fathi N, Hornik K, Fuchs K (2006) A GABRB3 promoter haplotype associated with childhood absence epilepsy impairs transcriptional activity Hum Mol Genet, 15: 2533-2541 | | o | Payne HL, Donoghue PS, Connelly WMK, Hinterreiter S, Tiwari P, Ives JH, Hann V, Sieghart W, Lees G, Thompson CL (2006) Aberrant GABA-A receptor expression in the dentate gyrus of the epileptic mutant mouse, stargazer J Neurosci, 26: 8600-8608 | | | Article (PDF) | | | | o | Swanwick CC, Murthy NR, Mtchedlishvili Z, Sieghart W, Kapur J (2006) Development of GABAergic Synapses in Cultured Hippocampal Neurons J Comp Neurol, 495: 497-510 | | | Article (PDF) | | | | o | Pifl C, Hornykiewicz O (2006) Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP treated rhesus monkeys. Neurochem Internat, 49: 519-524 | | o | Hanchar HJ, Chutsrinopkun P, Meera P, Supavilai P, Sieghart W, Wallner M, Olsen R (2006) Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABA-A receptors Proc Natl Acad Sci USA, 103: 8546-8551 | | | Article (PDF) | | | | o | Betz H, Gomeza J, Armsen W, Scholze P, Eulenburg V (2006) Glycine transporters: essential regulators of synaptic transmission Biochem. Soc. Trans., 34: 55-58 | | | Article (PDF) | | | | o | Tong J, Hornykiewicz O, Kish SJ (2006) Identification of a noradrenaline-rich subdivision of the human nucleus accumbens J Neurochem, 96: 349-354 | | o | Sarto-Jackson I, Ramerstorfer J, Ernst M, Sieghart W (2006) Identification of amino acid residues important for assembly of GABA-A receptor alpha1 and gamma2 subunits J Neurochem, 96: 983-995 | | | Article (PDF) | | | | o | Tong J, Hornykiewicz O, Kish SJ (2006) Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: a possible neuroprotective role for noradrenaline Arch Neurol, 63: 1724-1728 | | o | Ogris W, Lehner R, Fuchs K, Furtmüller B, Höger H, Homanics GE, Sieghart W (2006) Investigation of the abundance and subunit composition of GABA-A receptor subtypes in the cerebellum of alpha1-subunit-deficient mice J Neurochem, 96: 136-147 | | | Article (PDF) | | | | o | Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S (2006) Pharmacological properties of GABA-A receptors containing gamma1 subunits Mol Pharmacol, 69: 640-649 | | | Article (PDF) | | | | o | Berger M.L., Bitar A.Y., Waitner M.J., Rebernik P., O'Sullivan M.C. (2006) Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents. Bioorg Med Chem Lett, 16: 2837-2841 | | | Article (PDF) | | | | o | Buchstaller H.-P., Siebert C.D., Steinmetz R., Frank I., Berger M.L., Gottschlich R., Leibrock J., Krug M., Steinhilber D.,Noe C.R. (2006) Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the NMDA receptor. J Med Chem, 49: 864-871 | | | Article (PDF) | | | | 2006 Reviews | | o | Pifl C, Sperk G (2006) Current topics in brain dopamine research: a tribute to Professor Oleh Hornykiewicz Wiener Klinische Wochenschrift, 118: 563-565 | | o | Hornykiewicz O (2006) The discovery of dopamine deficiency in the parkinsonian brain Neural. Transm. Suppl., 70: 9-15 | | 2006 Book Chapters | | o | Sieghart W (2006) Structure, pharmacology and function of GABA-A receptor subtypes. In: (Eds.), Advances in Pharmacology 54 (Enna SJ) Elsevier Inc: 231-263 | | | Article (PDF) | | |
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