The structure of GABA_A receptors so far has not been solved by X-ray crystallography. But recently, structural information of a remote homologue of the GABA_A receptor, the acetylcholine binding protein, and later on also of the nicotinic acetylcholine receptor became available and was used for “in silico” modelling of GABA_A receptors by our group.  Results for the first time allowed to visualize the overall structure of GABA_A receptors and to identify possible binding sites for drugs interacting with these receptors.