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- Long-term potentiation is mostly mentioned as a mechanism for learning and memory. In the spinal cord LTP contributes to enhanced pain perception. -more-
- Beside activity-dependent synaptic long-term potentiation, long-term depression is considered to be a fundamental cellular mechanism of learning and memory in the hippocampus and in pain pathways. -more-
- Inhibitory interneurons releasing the neurotransmitter GABA play a pivotal role in pain processing in the spinal cord. Recently these neurons became accessible for profound investigation. -more-
- Chronic pain patients often suffer from touch-evoked pain. A mechanism underlying touch evoked pain is the violation of spinal sensory modality borders. -more-
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