About Us: Marion Gröger, Ph.D.

Curriculum Vitae

Present position

Group Leader

Current Project/s

• The action of fibrin fragments in the context of vascular leak and inflammation

Education

Publications

1. Demyanets S, Konya V, Kastl SP, Kaun C, Rauscher S, Niessner A, Pentz R, Pfaffenberger S, Rychli K, Lemberger CE, de Martin R, Heinemann A, Huk I, Gröger M, Maurer G, Huber K, Wojta J. Interleukin-33 Induces Expression of Adhesion Molecules and Inflammatory Activation in Human Endothelial Cells and in Human Atherosclerotic Plaques. Arterioscler Thromb Vasc Biol. 2011. Jul 7. [Epub ahead of print]
2. Schlager O, Giurgea A, Schuhfried O, Seidinger D, Hammer A, Gröger M, Fialka-Moser V, Gschwandtner M, Koppensteiner R, Steiner S. Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: A randomized controlled trial. Atherosclerosis. 2011. Jul;217(1):240-8. Epub 2011 Apr 8
3. Kretschy D, Gröger M, Zinkl D, Petzelbauer P, Koellensperger G, Hann S. High-throughput flow injection analysis of labeled peptides in cellular samples—ICP-MS analysis versus fluorescence based detection. Int J Mass Spectrom. 2011. 307:105-111
4. Gregor Hörmann, Sabine Cerny-Reiterer, Andrea Perné, Miriam Klauser,Konrad Hoetzenecker, Katharina Klein, Leonhard Müllauer, Marion Gröger, Sebastian M. B. Nijman, Walter Klepetko3, Peter Valent and Matthias Mayerhofer. Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis. Am.J.Pathol. in press. 2011.
5. Gröger M, Pasteiner W, Ignatyev G, Matt U, Knapp S, Atrasheuskaya A, Bukin E, Friedl P, Zinkl D, Hofer-Warbinek R, Zacharowski K, Petzelbauer P and Reingruber S. Peptide Bβ 15-42 preserves endothelial barrier function in shock. 2009. plos ONE 4(4): e5391
6. Koellensperger G, Gröger M, Zinkl D, Petzelbauer P, Hann S. Quantification of elemental labeled peptides in cellular uptake studies. J Anal Atom Spectrom 80, 264-271, 2009
7. Gröger M, Niederleithner H, Kerjaschki D, Petzelbauer P.
   A previously unknown dermal blood vessel phenotype in skin inflammation. J Invest Dermatol. 2007 Dec; 127(12):2893-900.
8. Holnthoner W, Kerenyi M, Gröger M, Kratochvill F, Petzelbauer P.
   Regulation of matrilysin expression in endothelium by fibroblast growth factor-2. Biochem Biophys Res Commun. 2006 Apr 14; 342(3):725-33. Epub 2006 Feb 14
9. Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Gröger M, Wolff K, Zacharowski K.
   The fibrin-derived peptide Bbeta(15-42) protects the myocardium against ischemia-reperfusion injury. Nat Med. 2005 Mar; 11(3):298-304
10. Gröger M, Loewe R, Holnthoner W, Embacher R, Pillinger M, Herron GS, Wolff K, Petzelbauer P.
    IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells. J Immunol. 2004 Dec 15; 173(12):7161-9
11. Kohrgruber N, Gröger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D.
    Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004 Dec 1; 173(11):6592-602
12. Ruger B, Giurea A, Wanivenhaus AH, Zehetgruber H, Hollemann D, Yanagida G, Gröger M, Petzelbauer P, Smolen JS, Hoecker P, Fischer MB.
    Endothelial precursor cells in the synovial tissue of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 2004 Jul; 50(7):2157-66
13. Holnthoner W, Pillinger M, Gröger M, Wolff K, Ashton AW, Albanese C, Neumeister P, Pestell RG, Petzelbauer P. Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells. J Biol Chem. 2002 Nov 29;277(48):45847-53
14. Loewe R, Holnthoner W, Gröger M, Pillinger M, Gruber F, Mechtcheriakova D, Hofer E, Wolff K, Petzelbauer P. Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells. J Immunol. 2002 May 1;168(9):4781-7
15. Gröger M, Petzelbauer P Mikrovaskulaere Endothelzellen in der Haut exprimieren den Makrophagen Mannose Rezeptor (180kD) in situ und in vitro. Immunologie Aktuell, 2001
16. Loewe R, Pillinger M, de Martin R, Mrowietz U, Gröger M, Holnthoner W, Wolff K, Wiegrebe W, Jirovsky D, Petzelbauer P. Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NF-kappa B-dependent manner. J Invest Dermatol. 2001, Dec; 117(6):1363-8
17. Kriehuber E, Breiteneder-Geleff S, Groeger M, Soleiman A, Schoppmann SF,Stingl G, Kerjaschki D, Maurer D. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J Exp Med. 2001 Sep 17; 194(6):797-808
18. Redlich K, Kiener HP, Schett G, Tohidast-Akrad M, Selzer E, Radda I, Stummvoll GH, Steiner CW, Gröger M, Bitzan P, Zenz P, Smolen JS, Steiner G. Overexpression of transcription factor Ets-1 in rheumatoid arthritis synovial membrane: regulation of expression and activation by interleukin-1 and tumor necrosis factor alpha. Arthritis Rheum. 2001 Feb; 44(2):266-74
19. Halama T, Gröger M, Pillinger M, Staffler G, Prager E, Stockinger H, Holnthoner W, Lechleitner S, Wolff K, Petzelbauer P. Platelet endothelial cell adhesion molecule-1 and vascular endothelial cadherin cooperatively regulate fibroblast growth factor-induced modulations of adherens junction functions. J Invest Dermatol. 2001 Jan; 116(1):110-7
20. Petzelbauer P, Halama T, Gröger M. Endothelial adherens junctions. J Investig Dermatol Symp Proc. 2000 Dec; 5(1):10-3. Review
21. Gröger M, Holnthoner W, Maurer D, Lechleitner S, Wolff K, Mayr BB, Lubitz W, Petzelbauer P. Dermal microvascular endothelial cells express the 180-kDa macrophage mannose receptor in situ and in vitro. J Immunol. 2000 Nov 15; 165(10):5428-34
22. Wagner L, Oliyarnyk O, Gartner W, Nowotny P, Groeger M, Kaserer K, Waldhausl W, Pasternack MS. Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein. J Biol Chem. 2000 Aug 11; 275(32):24740-51
23. Kohrgruber N, Halanek N, Gröger M, Winter D, Rappersberger K, Schmitt-Egenolf M, Stingl G, Maurer D.Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol. 1999 Sep 15;163(6):3250-9
24. Gröger M, Fischer GF, Wolff K, Petzelbauer P. Immune complexes from vasculitis patients bind to endothelial Fc receptors independent of the allelic polymorphism of FcgammaRIIa. J Invest Dermatol. 1999 Jul; 113(1):56-60
25. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 1999 May; 13(8):833-42
26. Gröger M, Matsumura T, Kohrgruber N, Maurer D, Wolff K, Petzelbauer P. A standardized, a computer-assisted in vitro assay for the assessment of neutrophil transmigration across endothelial monolayers. J Immunol Methods. 1999 Jan 1;222(1-2):101-9
27. Schett G, Redlich K, Xu Q, Bizan P, Gröger M, Tohidast-Akrad M, Kiener H, Smolen J, Steiner G. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest. 1998 Jul 15;102(2):302-1
28. Petzelbauer P, Gröger M. Cutaneous immune complex vasculitis: the role of Fc gamma receptors in precipitating the disease. J Dermatol. 1997 Nov; 24(11):730-1. Review
29. Kunstfeld R, Lechleitner S, Gröger M, Wolff K, Petzelbauer P. HECA-452+ T cells migrate through superficial vascular plexus but not through deep vascular plexus endothelium. J Invest Dermatol. 1997 Mar; 108(3):343-8
30. Petzelbauer P, Gröger M, Kunstfeld R, Petzelbauer E, Wolff K. Human delayed-type hypersensitivity reaction in a SCID mouse engrafted with human T cells and autologous skin. J Invest Dermatol. 1996 Oct; 107(4):576-81
31. Gröger M, Sarmay G, Fiebiger E, Wolff K, Petzelbauer P. Dermal microvascular endothelial cells express CD32 receptors in vivo and in vitro. J Immunol. 1996 Feb 15; 156(4):1549-56

Book chapters

1. Petzelbauer P, Gröger M, Loewe R, Kunstfeld R. 2007. Endothelium and skin. In: Aird, Ed. Endothelial Biomedicine. Cambridge U Press, p1431-1443

Awards

1. ÖGDV 2004
   IL-3 induces expression of lymphatic phenotypic markers Prox-1 and Podoplanin; presented in Graz, Styria, Austria
2. ÖGDV 2007
   A previously unknown dermal blood vessel phenotype in skin inflammation; presented in Vienna, Austria

Financial support