Division of Molecular and Biochemical Pathology

Head: Meinrad Peterlik, MD, PhD
Professor of Pathophysiology

The general tasks of the Division are
  • to promote research in pathophysiology related to major human diseases
  • to provide guidance and training in experimental medical research at the student and postdoctoral level at the Medical School and the School of Natural Sciences.
Research activities within the Division focus on investigations on
  • molecular and cellular mechanisms, which play a major role in
  • pathogenesis, therapy and prevention of
  • chronic and age-related degenerative and malignant diseases.
Particular research topics include
  • endocrine imbalances,
  • disturbances in the cytokine network and the interaction of
  • hormones, cytokines and growth factors
which cause aberrant regulation of
  • proliferation
  • differentiation and
  • function of various cell types.
According to the scientific expertise of the Group Leaders, research of the Division is oriented to the following diseases:
  • malignancies: colon, prostate and breast cancer
  • bone and joint diseases: osteoporosis and metabolic osteopathies, rheumatoid arthritis and related autoimmune diseases
  • bacterial and viral infections

RESEARCH GROUPS

Pathobiochemstry

Meinrad Peterlik, Ph.D., M.D. (Head)
Full Professor

Wolfgang Brozek, MA, Ph.D. student

Thomas Girsch, M. A., DMS student

Tumor Pathology

Heide S. Cross, Ph.D. (Head)
Associate Professor

Enikö Kállay, Ph.D. (Biochemistry)
Giovanna Bises, Ph.D. (Nutrition)
Maja Khorchide, M.D.
Manuel Zeitelhofer, M.D. student
Daniel Lechner, M.D. student
Erika Bajna, Lab Technician

Bone, Cartilage and Connective Tissue

Peter Pietschmann, M.D. (Head)
Associate Professor

Susanne Brosch, M.D.
Arno Wutzl, M.D.
Gabriela Sas, M.D.
Günther Hofbauer, Lab Technician

Cytokines

Martin Willheim, M.D. (Head)
Associate Professor

Genya Yamagida, M.D. student
Lino Ernstbrunner, M.D. student
Katharina Wahl, Ing., Lab Technician

Permanent staff:

Brigitte Freudhofmeier, Secretary
Teresa Manhardt, Ing., Lab Technician

CV OF GROUP LEADERS

Meinrad Peterlik, Ph.D., M.D.
Head, Department of Pathophysiology (formerly General and Experimental Pathology) University of Vienna, Austria

Date of birth: 5/23/38
Education
1963
1972
1974/75
 Ph.D in Chemistry, University of Vienna, Austria
M.D. in Medicine, University of Vienna, Austria
Postdoctoral training, Cornell University (Ithaca, NY, USA)
Research and/or professional experience:
1983

1978-83

1974-75

1964-78

 Full Professor of General and Experimental Pathology, Head, Department of General and Experimental Pathology
Associate Professor of General and Experimental Pathology, University of Vienna Medical School, Austria
Post-doctoral Fellow, Department of Physical Biology, NYS College of Veterinary Medicine, Cornell University, Ithaca, NY
Research Associate, Department of General and Experimental Pathology, University of Vienna Medical School
Specialization
(i) Main field: Pathophysiology
(ii) Other fields: Biochemistry, Cell Biology
(iii) Current research interests: cellular actions of vitamin D; calcium and phosphate homeostasis; cytokines and bone turnover; hormonal regulation of intestinal cell differentiation; pathogenesis and treatment of colon cancer; pathogenesis of osteoporosis
Memberships
Scientific Societies
American Institute of Nutrition
American Society of Bone and Mineral Research
European Calcified Tissue Society (Member of the Scientific Board, 1991-1997)
Austrian Biochemical Society
Austrian Society for Clinical Chemistry
Austrian Society for Bone and Mineral Research (President, 1991-97), Austrian Society for Pathology (Member of the Executive Board, 1984-99), Austrian Society for Endocrinology and Metabolism (Vice President 1995/96, President elect 1997/98, President 1999/2000)

Editorial Boards:
Bone (International, Multidisciplinary Journal of Bone Cell Biology, Physiology and Pathology) (until 1994)
Journal für Mineralstoffwechsel
Osteological Bulletin
Osteologie
Promed
The Scientific World (Associate Editor, Bone Biology Section)

Scientific Advisory Boards:
Österreichische Forschungsgemeinschaft
Ludwig-Boltzmann-Gesellschaft (until 1996)
Austrian UNESCO Commission
Institute for Ethics in Medicine, University of Vienna (until 1999)
Bioethikkommission beim Bundeskanzler der Republik Östertreich
Awards
Award of the "Hoechst"-Foundation for the Advancement of Medical Science in Austria 1971, 1976, 1980, 1984 and 1986
Österreichischer Staatspreis für Rheumaforschung 1985
Austrotransplant Research Prize 1987
Carl v. Rokitansky Prize for Research in Pathology 1989
Honorary Membership of the Slovak Rheumatological Society 2000
Erwin Uehlinger Medal of the German Society of Osteology 2002
Ad hoc Reviewer:
Journals:
American Journal of Physiology
Archives of Biochemistry and Biophysics
Biochimica Biophysica Acta
Diabetologia
Endocrinology
European Journal of Biochemistry
European Journal of Endocrinology
European Journal of Pharmacology
Experimental Gerontology
Immunbiology
International Archives of Allergy and Immunology
Journal of Bone and Mineral Research
Pflüger`s Archiv - European Journal of Physiology
Proceedings of the Society for Experimental Biology and Medicine
Wiener klinische Wochenschrift
Zeitschrift für Stomatologie
Grant Applications
Boehringer Foundation
Bundesministerium für Wissenschaft und Forschung
Deutsches Zentrum für Luft- und Raumfahrt (Projekttraeger des Bundesministeriums für Bildung und Forschung)
Fonds zur Förderung der wissenschaftlichen Forschung
Grant Agency of the Czech Republic
Jubiläumsstiftung der Österreichischen Nationalbank
Max Planck-Gesellschaft
Med.-wiss. Fonds des Bürgermeisters der Bundeshauptstadt Wien
Ministry of Health of the Czech Republic
National Science Foundation (USA)
Österreichische Akademie der Wissenschaften
USA-Israel Bilateral Agricultural Research and Development Fund
Juror
International Research Prize of the Austrian Society for Bone and Mineral Metabolism (formerly Chemofux Prize)
Carl von Rokitansky-Forschungspreis für Pathologie
Staatspreis für Rheumaforschung (Federal Award for Research in Rheumatology)
Herbert Czitober-Preis für Osteologie (Herbert Czitober Prize for Research in Osteology)

Heide S. Cross, Ph.D. Associate Professor

Date and Place of Birth: 16 July 1942, Vienna, Austria
Education:
1970: BSc (Biology, Honors) Univ. California, San Diego, USA
1972: MSc (Biology), Univ. California, San Diego, USA
1972-1974 Research Associate, Univ. California, Santa Cruz, USA (Departments of Chemistry and Biology)
1975-1978: PhD dissertation, Biochemistry, Univ. Vienna, Austria
1979 until present: Department of Pathophysiology, University of Vienna Medical School
1992: Foundation of group "Tumor Pathology"
1993: Venia docendi for Experimental Pathology
1994: Associate Professor, Univ. Vienna, Medical Faculty
Fellowships and postgraduate education:
March 1982: Baylor College of Medicine, Houston, Texas (Hormone Action and Molecular Endocrinology)
April 1987: In Situ Hybridization, Vienna, Austria
June 1987: FEBS Course: Biomembranes and Disease, Romania
1987-1989: Max Kade Fellowship of Medical Research, Cornell Univ., USA: Molecular and cellular mechanisms of growth factors in human colon cancer.
September 1989: Dept. of Pharmacology, Univ. Melbourne, Australia
October 1989: Garvan Institute of Medical Research, Sidney, Australia: Molecular biology of vitamin D receptor regulation
March/April 2000: Visiting Professor at the Kyoto University Medical Faculty, Japan
Award of the Hoechst Foundation for the Advancement of Medical Sciences in Austria 1980
Specialization:
Main field: Pathophysiology, specifically tumor pathology
Other areas of interest: epithelial function in health and disease, lymphocyte activation in epithelial tumors, nutrition and tumor pathogenesis, prevention of cancerogenesis, the calcium sensing receptor in health and disease, estrogenic and antiestrogenic steroid hormones in disease prevention.
Current research: Regulation of vitamin D synthesis and metabolism during human colorectal and prostatic tumor progression. The vitamin D receptor-knockout (VDR-KO) mouse as a model for premalignant colonic and prostatic changes. Prevention of premalignant changes in the colon and prostate of VDR KO mice by nutritional means.
Memberships:
Austrian Biochemical Society
Austrian Pathology Society
Austrian Society for Bone and Mineral Research
Austrian Society for Endocrinology and Metabolism
International Bone and Mineral Society
American Association for Cancer Research
International Society for Preventive Oncology
Ad hoc Reviewer:
Biochemical Pharmacology
Breast Cancer Research and Treatment
Cancer
Cancer Detection and Prevention
Carcinogenesis
Eur. J. Clinical Nutrition
Experimental Gerontology
Int. Arch. Allergy and Immunology
Int J Cancer
J Steroid Biochem Mol Biol
J. Clinical Oncology
Lancet
Grant proposal and dissertations:
ad Medical Research Program of the Eli and Edythe L. Broad Foundation, Los Angeles, Calif
Research Grants Committee of the NHS Trust, University Hospital Birmingham, England
Alberta Heritage Foundation for Medical Research, Alberta, Canada
Italian Association for Cancer Research (AICR)
World Cancer Research Fund London, England
German-Israeli Foundation for Scientific Research and Development, Jerusalem, Israel

Frequent reviewer for dissertations from University of Kuopio, Natural and Environmental Sciences, Kuopio, Finland

Peter Pietschmann, M.D. Associate Professor

Date of birth: 5/13/60
Education:
1966-1970
1970-1978
1978-1979
1979-1984
March 15, 1984
September 15, 1990
December 10, 1992

September 28, 1994
October 31, 2001
January 15, 2002

 Elementary School (Vienna)
Secondary School (Vienna)
Military Service
Medical School, University of Vienna
Graduation as Medical Doctor
Certification as Specialist of Internal Medicine
Appointment as Associate Professor of Internal Medicine, Medical School, University of Vienna
Certification as Specialist of Rheumatology
Certification as Specialist of Pathophysiology
Appointment as Associate Professor of Pathophysiology, Medical School, University of Vienna
Research and/or professional experience:
1984-1990
1990-1991
1991-1992

1992-1997

1997-1998
since May 1998:

 Department of Medicine 2, University of Vienna
Department of General and Experimental Pathology, University of Vienna
Rheumatic Diseases Division, Department of Internal Medicine, Southwestern Medical Center at Dallas, University of Texas, Dallas, TX, USA
Division of Rheumatology/Department of Internal Medicine 3 and Department of General and Experimental Pathology, University of Vienna
Institute of Immunology, University of Vienna
Department of General and Experimental Pathology , University of Vienna
Specialization:
(i) Main field: Pathophysiology
(ii) Other fields: Osteology, Immunology, Gerontology, Rheumatology
(iii) Current research interests: Osteoclastogenesis, cytokines and bone turnover, mechanism of action of bisphosphonates, pathophysiology and treatment of osteoporosis, osteoporosis in men, transendothelial migration of dendritic cells and monocytes, flow cytometry, aging and the immune system, transgenic animals for the study of the vitamin D system
Memberships:
Scientific societies:
International Bone and Mineral Society
Austrian Society for Bone and Mineral Research (Member of the Board)
Austrian Society for Geriatrics and Gerontology (Member of the Board)
Society for Internal Medicine of Vienna and Lower Austria
Austrian Society for Rheumatology
Austrian Society for Endocrinology and Metabolism
Austrian Diabetes Society
Medical Society of Vienna
Austrian Society for Cytometry

Affiliation with the Ludwig Boltzmann Institute for Aging Research, Vienna

Associate Editor
Wiener Medizinische Wochenschrift

Editorial Board:
Journal für Mineralstoffwechsel
Awards
Paracelsus Preis 1986
Young Investigator Award, World Congress of Osteoporosis 1996
Ad hoc reviewer:
Journals:
Acta endocrinologica (Copenh.)
Diabetologia
Experimental Gerontology
Journal für Mineralstoffwechsel
Wiener Klinische Wochenschrift
Wiener Medizinische Wochenschrift
Scandinavian Journal of Rheumatology
European Journal of Clinical Investigation
Rheumatology
European Surgery
Grant Applications:
Med.-wiss. Fonds des Bürgermeisters der Bundeshauptstadt Wien
Juror:
Federal Award for Research in Rheumatology
Herbert Czitober-Preis für Osteologie (Herbert Czitober Prize for Research in Osteology)
Dr. Kolassa-Rheumastiftung

Martin Willheim, M.D.

Date of birth: 8/31/62
Education:
1968-1972
1972-1980
1980-1994
Jan. 95
2001
2002
 Primary School (Linz)
Secondary School (Linz, Salzburg)
Medical Faculty, University of Vienna
Medical Doctor
Venia docendi for Pathophysiology
Associate Professor, Medical School, University of Vienna
Postdoctoral Education
1987
1991
1994
1996
1997
 Course in "Immunopathology", Dept. Gen. & Exp. Pathol.
Course in Cell Sorting by Flow Cytometry, Belgium
FEBS Summer School on Immunology, Greece
European Summer School on Clinical Applications of Flow Cytometry, Belgium
Keystone Symposium “Bone, Cartilage and Collagen: Growth and Differentiation“, USA
Research Experience:
1988-1992

1992-1995

since December 1995
03-09/2000
10/2000-09/2001
since October 2001

 Department of General and Experimental Pathology, University of Vienna (supported by the Austrian Science Research Fund)
Department of General and Experimental Pathology (partially supported by the Austrian Science Research Fund), and Department of Internal Medicine I, Division of Hematology & Hemostaseology, General Hospital of Vienna
Research Assistant at the Department of General and Experimental Pathology, Division of Molecular and Biochemical Pathology
Institute of Clinical Chemistry and Laboratory Medicine
Division of Rheumatology/Department of Internal Medicine III
Institute of Clinical Chemistry and Laboratory Medicine
Specialization:
(i) Main field: Pathophysiology
(ii) Other fields: Flow Cytometry, Immunology, Hematology
(iii) Current research interests: regulation of cytokine production, differentiation of cytokine producing T cell subsets, mechanisms of vitamin D effects on T cells and monocytes; role of cytokines and hormones in osteoclastogenesis and bone turnover; crossregulation of tumor cells and infiltrating leukocytes, regulation of MHC molecules in tumor cells by cytokines
Membership in Academic Societies:
Austrian Society of Allergy and Immunology
Society for Leukocyte Biology
International Society for Analytical Cytology
Austrian Society for Bone and Mineral Researc"
International Bone and Mineral Society
Austrian Society for Cytometry (President)
Ad hoc Reviewer:
Journal of Immunological Methods
Program Committees
15th Annual Meeting of the European Macrophage Society (EMS), Vienna, August 30 – September 1, 2001
Awards:
Awards of the „Hoechst“-Foundation for the Advancement of Medical Science in Austria 1994 and 1995

RESEARCH TOPICS

Pathobiochemistry

1. Modulation of Tumor Growth and Tumor Immunity in Colorectal Cancer: Role of Cytokines and Steroid Hormones
2. Influence of calcium and vitamin D status on bone health

Tumor Pathology

1. Premalignant and early malignant markers of human colorectal tumors
2. Site- and gender-specific development of human colorectal cancer
3. Investigation of the vitamin D system as physiological defense against colon, prostate, mammary tumor progression
4. Induction of the vitamin D system by nutritional factors, such as phytoestrogens and calcium
5. Knockout of the vitamin D receptor for initiation and promotion of malinancies
6. Interaction between malignant epithelial cells and tumor-infiltrating leukocytes on cytokine production

Bone, Cartilage and Connective Tissue

The primary aim of the research group is to investigate the pathophysiology of important bone and joint diseases (such as osteoporosis or rheumatoid arthritis) in particular with regard to interactions between the endocrine and the immune system.

1. Studies on the regulation of the generation of osteoclasts
2. Effects of sex hormones on cytokine production by mononuclear cells
3. Interactions between the vitamin D system on the immune system
4. Studies of bone metabolism in a model of osteoporosis in men
5. Pathogenesis of bone erosions and osteoporosis in inflammatory rheumatic diseases

Cytokines

1. Characterization of functional leukocyte subpopulations by their cytokine production patterns
2. Effects of the vitamin D system on cytokine production
3. Cytokine production patterns of leukocytes in the pathophysiology of infectious diseases (e.g. Sepsis, Malaria, viral infections)
4 Regulation of antigen presenting cell (APC) function by cytokines
5. Cytokines and hormones in human monocytic cell differentiation to macrophages, dendritic cells and osteoclasts
6. Cytokines in the pathophysiology of bone metabolism
7. Basic and clinical applications of flow cytometry

SELECTED PROJECTS

Functional Characterization of Tumor Infiltrating Leukocytes (TIL) and Tumor Cells in Colorectal Carcinoma (CRC) (M. PETERLIK, G. BISES, H. S. CROSS, M. WILLHEIM), gefördert von Boehringer Ingelheim Austria

Possible role of Interleukin-6 (IL-6) in modulation of tumor growth and immunity in human colorectal cancer (M. PETERLIK und H. E. Kaiser), gefördert vom Jubiläumsfonds der Österreichischen Nationalbank

Phytoestrogens and human colorectal cancer prevention – regulation of the vitamin D growth control system (H. S. CROSS) gefördert von World Cancer Research Fund

Regulation of the vitamin D growth control system by estrogen: relevance for human colorectal cancer prevention (H. S. CROSS), gefördert vom Jubiläumsfonds der Österreichischen Nationalbank

Oral calcium and colorectal cancer prevention: mechanisms of action in an animal model (E. KALLAY, H. S.CROSS), gefördert vom Jubiläumsfonds der Österreichischen Nationalbank

Development and refinement of a Caco-2 cell in vitro model of intestinal barrier function (H.S. CROSS, G. BISES), gefördert als Cost Project, European Union (ISS/ECVAM contract)

Molekulare Mechanismen der fehlenden Induzierbarkeit von MHC Klasse II Molekülen durch IFN-g an humanen Hepatomzellinien (M. WILLHEIM), gefördert vom Jubiläumsfonds der Österreichischen Nationalbank

Leberspezifischer nicht-viraler Endostatin-Gentransfer durch Polyethylenimin-Polyethylenglykol Blockcopolymere (M. WILLHEIM), gefördert von Jubiläumsfonds der Österreichischen Nationalbank

Untersuchung der defekten IFN-gamma Signaltransduktion bei humanen Hepatomzellinien. Gemeinsame Regulation der HLA-DR Expression und Proliferationshemmung durch PKR und IRF-1 (M. WILLHEIM, W. REINISCH), gefördert von Kommission „Onkologie“ (Krebsforschung)

Einfluß von 1alpha,25-Dihydroxyvitamin D3 auf die Differenzierung von humanen T Zell Subpopulationen: Wechselwirkungen mit Zytokinen (M. WILLHEIM)
Anton-Dreher-Gedächtnisschenkung für Medizinische Forschung

The relationship of cytokines, sex steroids and bone turnover in aging men and women (P. PIETSCHMANN) gefördert vom Jubiläumsfonds der Österreichischen Nationalbank

Die Bedeutung des Vitamin D-Rezeptors für die Zytokinproduktion von T-Lymphozyten (P. PIETSCHMANN), gefördert vom Medizinisch-wissenschaftlichen Fonds des Bürgermeisters der Bundeshauptstadt Wien

Zelluläre Zytokinproduktion im septischen Schock – Einfluß von Hydrocortison (M. WILLHEIM, S. KNAPP, S. WINKLER), gefördert von Medizinisch-wissenschaftlichen Fonds des Bürgermeisters der Bundeshauptstadt Wien

SELECTED PUBLICATIONS

2002:
PICHLER J, GERSTMAYR M, SZEPFALUSI Z, URBANEK R, PETERLIK M, WILLHEIM M. 1 alpha,25(OH)2D3 inhibits not only Th1 but also Th2 differentiation in human cord blood T cells. Pediatr Res. 2002 Jul;52(1):12-8.

K. REDLICH, S. HAYER, A. MAIER, CR. DUNSTAN , M. TOHIDAST-AKRAD S. LANG, B. TÜRK, P. PIETSCHMANN, W. WOLOSZCZUK, S. HARALAMBOUS, G. KOLLIAS, G. STEINER, JS. SMOLEN, G. SCHETT (2002) Tumor necrosis factor _-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum 46: 785 – 792

J. GRISAR, PM. BERNECKER, M. ARINGER, K. REDLICH, M. SEDLAK, W. WOLOZCSZUK, S. SPITZAUER, S. GRAMPP, F. KAINBERGER, W. EBNER, JS. SMOLEN, P. PIETSCHMANN (2002). Ankylosing spondylitis, psoriatic arthritis, and reactive arthritis show increased bone resorption, but differ with regard to bone formation. J Rheumatol 29: 1430 – 1436

LERNBASS I., A. WUTZL, J. GRISAR, G. SCHETT, K. REDLICH, S. SPITZAUER, S. GRAMPP, H. IMHOF, M. PETERLIK, P. PIETSCHMANN (2002) Quantitative ultrasound in the assessment of bone status of patients suffering from rheumatic diseases. Skeletal Radiol 31: 270 – 276

KALLAY E, ADLERCREUTZ H, FARHAN H, LECHNER D, BAJNA E, GERDENITSCH W, CAMPBELL M, CROSS HS. Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapy. J Nutr. 2002 Nov;132(11 Suppl):3490S-3493S.

FARHAN H, WAHALA K, ADLERCREUTZ H, CROSS HS. Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells. J Chromatogr B Analyt Technol Biomed Life Sci. 777(1-2):261-268,2002

KALLAY E, BAREIS P, BAJNA E, KRIWANEK S, BONNER E, TOYOKUNI S, CROSS HS. Vitamin D receptor activity and prevention of colonic hyperproliferation and oxidative stress. Food Chem Toxicol. 40:1191-1196, 2002

BAREIS P, KALLAY E, BISCHOF MG, BISES G, HOFER H, POTZI C, MANHARDT T, BLAND R, CROSS HS. Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3). Exp Cell Res. 2002 276(2):320-7.

WOLSCHEK MF, THALLINGER C, KURSA M, ROSSLER V, ALLEN M, LICHTENBERGER C, KIRCHEIS R, LUCAS T, WILLHEIM M, REINISCH W, GANGL A, WAGNER E, JANSEN B. Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice. Hepatology. 2002 Nov;36(5):1106-14.

GEISSLER K, KABRNA E, KOLLARS M, OHLER L, BERER A, BURGMANN H, WINKLER S, WILLHEIM M, HINTERBERGER W, LECHNER K. Interleukin-10 inhibits in vitro hematopoietic suppression and production of interferon-gamma and tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with aplastic anemia. Hematol J. 2002;3(4):206-13.

RAUSCH-FAN X, LEUTMEZER F, WILLHEIM M, SPITTLER A, BOHLE B, EBNER C, JENSEN-JAROLIM E, BOLTZ-NITULESCU G. Regulation of cytokine production in human peripheral blood mononuclear cells and allergen-specific th cell clones by 1alpha,25-dihydroxyvitamin D3. Int Arch Allergy Immunol. 2002 May;128(1):33-41.

JENSEN-JAROLIM E, GSCHEIDLINGER R, OBERHUBER G, NEUCHRIST C, LUCAS T, BISES G, RADAUER C, WILLHEIM M, SCHEINER O, LIU FT, BOLTZ-NITULESCU G. The constitutive expression of galectin-3 is downregulated in the intestinal epithelia of Crohn's disease patients, and tumour necrosis factor alpha decreases the level of galectin-3-specific mRNA in HCT-8 cells. Eur J Gastroenterol Hepatol. 2002 Feb;14(2):145-52.

SCHETT G, WINKLER S, HOLLENSTEIN U, AMANN G, WILLHEIM M, PROKOP M, KLEPETKO W, BECHERER A, SMOLEN J, GRANINGER W. Obstruction of the pulmonary artery by granulomatous vasculitis: a clinical, morphological, and immunological analysis. Ann Rheum Dis. 2002 May;61(5):463-7. Review

2001:

H. S. CROSS, P. BAREIS, H. HOFER, M. G. BISCHOF, E. BAJNA, S. KRIWANEK, E. BONNER, M. PETERLIK: 25-Hydroxyvitamin D3-1-alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids 66:287-292, 2001

P. BAREIS, G. BISES, M.G. BISCHOF, H.S. CROSS, M. PETERLIK: 25-hydroxyvitamin D metabolism in human colon cancer cells during tumor progression. Biochem. Biophys. Res. Comm. 285: 1012-1017, 2001

E. KALLAY, P.PIETSCHMANN, S. TOYOKUNI, E. BAJNA, P. HAHN, K. MAZZUCCO, C. BIEGLMAYER, S. KATO, H.S. CROSS: Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage. Carcinogenesis 22: 1429-1435, 2001

E. KALLAY, P. BAREIS, E. BAJNA, S. KRIWANEK, E. BONNER, S. TOYOKUNI, H.S. CROSS: The protective effect of 1,25-dihydroxyvitamin D3 against colonic hyperproliferation and oxidative stress. Food and Chemical Toxicology, in print 2001

P. BAREIS, M.G. BISCHOF, H. HOFER, C. PÖTZI, T. MANHARDT, R. BLAND, H.S. CROSS: Clonal differences in expression of 25-hydroxyvitamin D3-1alpha-hydroxylase, of 25-hydroxyvitamin D3-24-hydroxylase and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D3. Exp Cell Res., in revision 2001

H. FARHAN, K. WÄHÄLÄ, H. ADLERCREUTZ, H.S. CROSS: Isoflavones inhibit catabolism of vitamin D in prostate cancer cells. J Chromatography B, in print 2001

J. GRISAR, P. HAHN, S. BROSCH, M. PETERLIK, J. S. SMOLEN, P. PIETSCHMANN: Phenotypical characteristics of human monocytes undergoing transendothelial migration. Arthritis Res. 3:127-132, 2001

P. PIETSCHMANN, S. KUDLACEK, J. GRISAR, S. SPITZAUER, W. WOLOSZCZUK, R. WILLVONSEDER, M. PETERLIK: Bone turnover markers and sex hormones in men with idiopathic osteoporosis: significance for the pathophysiology of bone loss. Eur. J. Clin. Invest.31:444-451, 2001

J. PICHLER, M. GERSTMAYER, Z. SZÉPFALUSI, R. URBANEK, M. PETERLIK and M. WILLHEIM: Regulation of cord blood T cell cytokines by 1alpha,25(OH). Pedriatic Research, in press

P. PIETSCHMANN, J. GRISAR, R. THIEN, M. WILLHEIM, K. KERSCHAN-SCHINDL, E. PREISINGER, and M. PETERLIK: Immune phenotype and intracellular cytokine production of peripheral blood mononuclear cells from postmenopausal patients with osteoporotic fractures. Exp. Gerontol. 36:1749-1759, 2001

2000:

E. KÁLLAY, E. BAJNA, F. WRBA, S. KRIWANEK, M. PETERLIK, H. S. CROSS: Dietary calcium and growth modulation of human colon cancer cells: Role of the extracellular calcium-sensing receptor. Cancer Detection Prevention 24: 127-136, 2000

Y. SHEININ, K. KASERER, F. WRBA, E. WENZL, R. PÖTZI, R.ROKA, N. NEUHOLD, A. ELLINGER, M. PETERLIK, H.S. CROSS: In situ mRNA hybridization of vitamin D receptor and epidermal growth factor receptor expression in human colonic mucosa during tumor progression. Virchows Arch. 437: 501-507, 2000

Y. SHEININ, E. KÁLLAY, K. KASERER, F. WRBA, M. PETERLIK, H. S. CROSS: Differential expression of the calcium-sensing receptor in normal and cancerous human large intestinal mucosa: immunocytochemical evaluation. J. Histochem. Cytochem. 48:595-601, 2000

X.T. WANG, Y. NAGABA, H.S. CROSS, F. WRBA, L. ZHANG, S.E. GUGGINO: The mRNA of L-Type Calcium Channel Elevated in Colon Cancer. Am. J. Pathol. 157: 1549-1562, 2000

J. PAMMER, H.S. CROSS, Y. FROBERT, E. TSCHACHLER, G. OBERHUBER: The pattern of prion-related protein expression in the gastrointestinal tract. Virchows Arch 436: 466-472, 2000

S. M. ZAKERI, H. MEYER; G. MEINHARDT, W. REINISCH, K. SCHRATTBAUER, M. KNOEFLER, L. H. BLOCK: Effects of trovafloxacin on the IL-1-dependent activation of E-selectin in human endothelial cells in vitro. Immunopharmacology.

PIETSCHMANN P, HAHN P, KUDLACEK S, THOMAS R, PETERLIK M: Surface markers and transendothelial migration of dendritic cells from elderly subjects. Exp Gerontol 35: 213 – 224, 2000

REDLICH K, ZIEGLER S, KIENER HP, SPITZAUER S, STOHLAWETZ P, BERNECKER P, KAINBERGER F, GRAMPP S, KUDLACEK S, WOLOSZCZUK W, SMOLEN JS, PIETSCHMANN P : Bone mineral density and biochemical parameters of bone metabolism in female patients with systemic lupus erythematosus. Ann Rheum Dis 59: 308 – 310, 2000

ARINGER M, VIERHAPPER H, GRANINGER MT, BERNECKER P, SMOLEN JS, PIETSCHMANN P : Successful treatment of high turnover osteoporosis in a patient with adrenocortical insufficiency. Wien Klin Wochenschr 112: 334 – 337, 2000

ORWOLL E, ETTINGER M, WEISS S, MILLER P, KENDLER D, GRAHAM J, ADAMI S, WEBER K, LORENC R, PIETSCHMANN P, Silverman S, Felsenberg D, Vandormael K, Daifotis A, Lombardi A : Alendronate treatment of osteoporosis in men. N Engl J Med 343: 604 – 610, 2000

R. GRUBER, G. NOTHEGGER, GM. HO, M. WILLHEIM, M. PETERLIK: Differential stimulation by PGE(2) and calcemic hormones of IL-6 in stromal/osteoblastic cells. Biochem Biophys Res Commun 270(3): 1080-5, 2000

R. GRUBER, C. MAYER, W. SCHULZ, W. GRANINGER, M. PETERLIK, F. P. LUYTEN, L. ERLACHER: Stimulatory effects of cartilage-derived morphogenetic proteins-1 and -2 on osteogenic differentiation of bone marrow stromal cells. Cytokine 12:1630-1638, 2000
1999:
WINKLER S., WILLHEIM M., BAIER K., SCHMID D, AICHELBURG A., GRANINGER W., KREMSNER P.G.: Frequency of cytokine-producing T cells in patients of different age groups with Plasmodium falciparum malaria. J Infect Dis 179:209-216, 1999

R. GRUBER, K. CZERWENKA, F. WOLF, G.-M. HO, M. WILLHEIM, M. PETERLIK: Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor alpha and beta-isoforms, and of the androgen receptor in cultures of native mouse marrow and of stromal/osteoblastic cells. Bone 24: 465-473, 1999

W.-M. TONG, H. HOFER, A. ELLINGER, H. S. CROSS: Mechanism of anti-mitogenic action of vitamin D in human colon carcinoma cells: relevance for suppression of epidermal growth factor-stimulated cell growth. Oncol. Res. 11:77-84, 1999

M. WILLHEIM, R. THIEN, K. SCHRATTBAUER, E. BAJNA, M. HOLUB, R. GRUBER, K. BAIER, P. PIETSCHMANN, W. REINISCH, O. SCHEINER, M. PETERLIK: Regulatory effects of 1a-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. J. Clin. Endocrinol. Metab. 84: 3739-3744, 1999

H. HOFER, G.-M. HO, M. PETERLIK, M. R. USKOKOVIC, J. K. LEE, M. C. WHITE, G. H. POSNER, H. S. CROSS: Biological effects of 1a-hydroxy- and 1b-(hydroxymethyl) vitamin compounds relevant for potential colorectal cancer therapy. J. Pharmacol. Exp. Therap. 291:450-455, 1999

W.-M. TONG, T. MANHARDT, H. LASSNIG, H.S. CROSS: Induction of epidermal growth factor receptor expression and mitogenesis by alcohol in human colon adenocarcinoma-derived Caco-2 cells. Anticancer Res. 19:3321-3326, 1999

F. WIMAZAL, M. GHANNADAN, MR. MÜLLER, A. END, M. WILLHEIM, P. MEIDLINGER, GH. SCHERNTHANER, JH. JORDAN, W. HAGER, H. AGIS, WR. SPERR, K. CZERWENKA, K. LECHNER, P. VALENT: Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multicolor flow cytometry and toluidine blue/immunofluorescence staining techniques.
Tissue Antigens 54:499-507, 1999

HJ. BÜHRING, PJ. SIMMONS, M. PUDNEY, R. MÜLLER, D. JARROSSAY, A. VAN-AGTHOVEN, M. WILLHEIM, W. BRUGGER, P. VALENT, L. KANZ: The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors
Blood 94:2343-2356, 1999

C. LICHTENBERGER, S. ZAKERI, K. BAIER, M. WILLHEIM, M. HOLUB, W. REINISCH:
A novel high-purity isolation method for human peripheral blood neutrophils permitting polymerase chain reaction-based mRNA studies. J. Immunol. Methods 227:75-84, 1999

W. REINISCH, C. GASCHE, W. TILLINGER, J. WYATT, C. LICHTENBERGER, M. WILLHEIM, C. DEJACO, T. WALDHOR, S. BAKOS, H. VOGELSANG, A. GANGL, H. LOCHS: Clinical relevance of serum interleukin-6 in Crohn's disease: Single point measurements, therapy monitoring and prediction of clinical relapse
Am. J. Gastroenterol. 94:2156-2164, 1999

S. WINKLER, M. WILLHEIM, K. BAIER, W. GRANINGER, PG. KREMSNER: Frequency of cytokine-producing CD4(-)CD8(-) peripheral blood mononuclear cells in patients with Plasmodium falciparum malaria
Eur. Cytokine Netw 10:155-160, 1999

S. WINKLER, M. WILLHEIM, K. BAIER, A. AICHELBERG, PG. KREMSNER, W. GRANINGER:
Increased frequency of TH2-type cytokine-producing T cells in microfilaremic loiasis
Am. J. Trop. Med. Hyg. 60:680-686, 1999

C. SILLABER, BAGHESTANIAN, D. BEVEC, M. WILLHEIM, H. AGIS, S. KAPIOTIS, W. FÜREDER, HC. BANKL, HP. KIENER, W. SPEISER, BR. BINDER, K. LECHNER, P. VALENT: The mast cell as site of tissue-type plasminogen activator expression and fibrinolysis
J. Immunol. 162:1032-1041, 1999

K. KERSCHAN-SCHINDL, E. UHER, E. PREISINGER, P. PIETSCHMANN: Anwendung des in die deutsche Sprache übersetzten Osteoporosis Quality of Life Questionnaire (OQLQ). Wien Klin Wochenschr 111: 608 – 611, 1999

G. GRISAR, S. TRAVICA , M. METKA, P. PIETSCHMANN: Hormonersatztherapie mit 17beta-Östradiol-Dydrogesteron: Ergebnisse einer dreimonatigen Anwendungsbeobachtung. Wien Klin Wochenschr 111: 1035 – 1043, 1999