Michael Kiebler and his first two students, Martin Köhrmann and Kavish Hemraj, started as part of the Dotti lab at the EMBL in Heidelberg, Germany in 1997. Here, they co-discovered the mammalian Staufen proteins and subsequently began to investigate Staufen-dependent mRNA transport into dendrites of hippocampal neurons. In 1999, the Kiebler lab moved to the Max-Planck-Institute for Developmental Biology in Tübingen, Germany, where the continued to study the molecular mechanisms of dendritic RNA transport and local protein synthesis in rat hippocampal neurons. Since 2005, the Kiebler lab now resides in the CBR.
Synapsen, die Kontaktstellen zwischen den Nervenzellen im Gehirn, spielen eine Schlüsselrolle beim Lernen. Weltweit dringen Forscher langsam immer tiefer in die dabei ablaufenden chemischen Mechanismen ein. Eine neue Studie, die unter Federführung einer Forschergruppe an der MUW entstanden ist, liefert nun neue Aufschlüsse über die molekularen Protagonisten dieser Prozesse.
High Throughput Nucleofection® of Primary Rat Hippocampal Neurons
by Manuel Zeitelhofer1, Sabine Thomas1, Markus Zumbansen2 and Fabian Tübing11 Division of Neuronal Cell Biology, Kiebler Lab, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria2 amaxa GmbH, Cologne, Germany
