Publications
Year 2001
Bene, M.C., M.Bernier, R.O.Casasnovas, G.Castoldi, D.Doekharan, R.v.d.Holt, W.Knapp, P.Lernez, W.D.Ludwig, E.Matutes, A.Orfao, C.Schoch, C.Sperling, and M.B.van't Veer (for EGIL). Acute myeloid leukemia (AML) M0: Hematological, immunophenotypical and cytogeneic characteristics and their prognostic significance. An analysis in 241 patients. Brit.J.Haemtol.113:737-745 (2001)
Böhmig, G.A., M.Exner, B.Watschinger, C.Wenter, M.Wahrmann, C.Österreicher, M.D.Säemann, N.Mersich, W.H.Hörl, G.J.Zlabinger and H.Regele. C4d deposits in renal allografts are associated with inferior graft outcome. Transplant.Proc. 33:1151-1152 (2001)
Diakos, C., E.Prieschl, M.Säemann, G.Böhmig, T.Baumruker and G.J.Zlabinger. Selective inhibition of NF-AT DNA binding by the short-chain fatty acid n-butyrate. Transplant. Proceed.33:197-198 (2001)
Donnadieu, E., Lang, V., Michel, F., Ellmeier, W., Acuto, O., Bismuth, G. and Trautmann, A. Differential roles of Lck and Itk in the interaction between T lymphocytes and antigen-presenting cells. J.Immunol. 166, 5540-9 (2001)
Emminger, W., G.J.Zlabinger, G.Fritsch and R.Urbanek. CD14dim/CD16bright monocytes in hemophagocytic lymphohistiocytosis Eur.J. Immunol. 31: 1716-1719 (2001)
Körmöczi, G., U.M.Wölfel, A.R.Rosenkranz, W.H.Hörl, R.Oberbauer, and G.J.Zlabinger. Serum proteins modified by neutrophil-derived oxidants as mediators of neutrophil stimulation. J.Immunol. 167: 451-460 (2001)
Pickl, W.F., O.Majdic, and W.Knapp. Dendritic cell generation from highly purified CD14+ monocytes. Methods in Molecular Medicine. "Dendritic Cell Protocols" (Eds., S.Robinson, A.Stagg), Humana Press 283-296 (2001)
Pickl, W., F.X.Pimentel-Muinos, and B.Seed Lipid rafts and pseudotyping. J.Virol. 75: 7175-7183 (2001)
Prager, E., G. Staffler, O. Majdic, M. D. Säemann, S. Godár, G. J. Zlabinger, and H. Stockinger. Induction of hyporesponsiveness and impaired T lymphocyte activation by the CD31 receptor:ligand pathway in T cells. J.Immunol. 166:2364-2371 (2001)
Regele, H., M.Exner, B.Watschinger, C.Wenter, M.Wahrmann, C.Österreicher, M.D.Säemann, N.Mersich, W.H.Hörl, G.J.Zlabinger and G.A.Böhmig. Endothelial C4d deposition is associated with inferior kidney allograft outcome idependently of cellular rejection. Nephrol.Dial.Transplant. 16: 2058-66 (2001)
Rosenkranz, A., E.Peherstorfer, G.F.Körmöczi, G.J.Zlabinger, G.Mayer, W.H.Hörl, and R.Ober-bauer. Complement-dependent acceler-ation of apoptosis in neutrophils by dialyzer membranes. Kidney Int. 59: 216-220 (2001)
Säemann, M.D., C.Diakos, G.Staffler, G.A.Böhmig, C.H.Österreicher, H.Stockinger and G.J.Zlabinger. Modulation of primary T cell responses and tolerance induction by tyrphostin AG 490. Transplant.Proc. 33:132-133 (2001)
Selenko, N., O.Majdic, S.Draxler, A.Berer, U.Jäger, W.Knapp and J.Stöckl. CD20 antibody (C2B8) induced apoptosis of lymphoma cells promotes phagocytosis by dendritic cells and cross-priming of CD8+ cytotoxic T-cells. Leukemia 15:1619-1626 (2001)
Stöckl, J., O.Majdic, G.Fischer, D.Maurer, and W.Knapp. Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1 restricted, hapten-specific CTL. J.Immunol. 167: 2724-2733 (2001)
Waclavicek, M., A.Berer, L.Öhler, C.Bello, J.Stöckl, O.Majdic and W.Knapp. Calcium ionophore: A single reagent procedure for the differentiation of primary human acute myelogenous leukemia cells towards dendritic cells. Brit.J.Haematol.114: 466-473 (2001)
Wille, S., A.Szekeres, O.Majdic, E.Prager, G.Staffler, J.Stöckl, D.Kunthalert, E.E.Prieschl, T.Baumruker, H.Burtscher, G.J.Zlabinger, W.Knapp and H.Stockinger. Characterization of CDw92 as member of the choline transporter-like protein family regulated specifically on dendritic cells. J.Immunol.167: 5795-5804 (2001)
Zlabinger, G.J. Grundlagen der Autoimmunität. Berichte der ÖGKC 24:1, 23-24 (2001)
Zlabinger, G.J. Immunologische Grundlagen von Entzündungsreaktionen. In: Praktische Rheumatologie, Bröll, H., Czurda, R., Siegmeth, W., Smolen, J., Thumb, N. (eds.), Springer Wien-New York, p18-32 (2001)
Year 2002
Diakos, C., E.E.Prieschl, M.Säemann, V.Novotny, G.Böhmig, R.Csonga, T.Baumruker, and G.J.Zlabinger. Novel mode of interference with nuclear factor of activated T-cells. Regulation in T-cells by the bacterial metabolite n-Butyrate. J.Biol.Chem. 277:24243-24251 (2002)
Ellmeier, W., M.J.Sunshine, R.Maschek and D.R.Littman. Combined deletion of CD8 Locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16:623-634 (2002)
Javaherian, K., S.Y.Park, W.F.Pickl, K.R. LaMontagne, R.T.Tham Sjin, S.Gillies, and K.M.Lo. Laminin modulates morphogenic properties of the collagen XVIII endostatin domain. J.Biol.Chem. 277:452111-45218 (2002)
Keppler, O.T., Welte, F.J., Ngo, T.A., Kathryn S. Patton, K.S., Tsou, C.L., Abbey, N.W. Sharkey, M.E., Yun You, Y., Scarborough, J.D., Ellmeier, W., Littman, D.R., Stevenson, M., Charo, I.F., Herndier, B.G., Speck, R.F., and Goldsmith, M.A. Progress toward a human CD4/CCR5-transgenic rat model for de novo Infection by human immunodeficiency virus type 1. J.Exp.Med. 195, 719-36 (2002)
Kioussis D. and W.Ellmeier. Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat. Rev. Immunol. 12:909-19 (2002)
Krieger, P., M.Säemann, G.Böhmig, F.Mühlbacher, and G.Zlabinger. Targeting the ERK-1/2 signalling pathway results in alloantigen-specific aergy in human T cells. Transplant. Proc. 34: 1403 (2002)
Parolini, O., B.Kagerbauer, I.Simonitsch-Klupp, P.Ambros, U.Jäger, G.Mann, O.H.Haas, M.Morra, H.Gadner, C.Terhorst, W.Knapp and W.Holter. Analysis of SAP/SH2D1A mutations in patients with severe Epstein-Barr virus infections, Burkitt's lymphoma, and Hodgkin's lymphoma. Ann.Hematol. 81: 441-447 (2002)
Säemann, M.D., G.A.Böhmig, and G.J.Zlabinger. Short-chain fatty acids: bacterial mediators of a balanced host-microbial relationshiop in the human gut. Wr.klin.Wschr. 114:289-300 (2002)
Säemann, M.D., O.Parolini, G.A.Böhmig, P.Kelemen, P.M.Krieger, J.Neumüller, K.Knarr, W.Kammlander, W.H.Hörl, C.Diakos, K.Stuhlmeier, and G.J.Zlabinger. Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells. J.Leukoc.Biol. 71:238-246 (2002)
Säemann, M.D., P. Kelemen, M.Zeyda, G.Staffler, and G.J.Zlabinger. CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited. Transpl. Proc. 34:1407-1408 (2002)
Schernthaner, G.H., J.H.Jordan, H.Agis, D.Bevec, R.Nunez, L.Escribano, O.Majdic, M.Wilheim, C.Worda, D.Prinz, G.Fritsch, K.Lechner and P.Valent. Expression, epitope analysis and functional role of the LFA-2 antigen detectable on neoplastic mast cells. Blood 98:3784-3792 (2002)
Schoppmann, S.F., P.Birner, J.Stöckl, R.Kalt, R.Ullrich, E.Kriehuber, K.Nagy, K.Alitalo, and D.Kerjaschki. Tumor associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am.J.Pathol.161:947-956 (2002)
Selenko, N., O.Majdic, U.Jäger, C.Sillaber, J.Stöckl, and W.Knapp. Cross priming of cytotoxic T-cells promoted by apoptosis inducing tumor cell reactive antibodies? J.Clin.Immunol. 22:124-130 (2002)
Staffler, G., M. D. Säemann, E. Prager, G. J. Zlabinger, Ml. Zeyda, T.Stulnig, I. Hilgert, V. Horejsi, and H. Stockinger. T cell inhibition by antibody targeting of the CD147 molecule. Leukocyte Typing VII, D.Mason et al. (eds.), Oxford University Press, Oxford-New York-Tokyo, 710-712 (2002)
Steinberger,P., A.Szekeres, S.Wille, J.Stöckl, N.Selenko, E. Prager,G. Staffler,O. Majdic, H.Stockinger, and W. Knapp. Identification of Human CD93 as the Phagocytic C1q Receptor (C1qRp) by Expression Cloning. J.Leukocyte Biol. 71:133-140 (2002)
Wille, S., O Majdic, E. Prager, G. Staffler, A. Szekeres, J. Stöckl, W. Knapp, and H. Stockinger. Retroviral expression cloning of the CDw92 molecule. Leukocyte Typing VII, D.Mason et al. ed., Oxford Univ.Press, Oxford, New York, Tokyo, 365-366 (2002)
Year 2003
Atkinson, B., W.Ellmeier, and S.P.Watson. Tec regulates platelet activation by GPVI in the absence of Btk. Blood 102: 3592-3599 (2003)
Bello-Fernandez, C., J.Stasakova, A.Renner, N.Carballido-Perrig, M.König, M.Waclavicek, O.Majdic, L.Öhler, O.Haas, J.Carballido, M.Buschle and W.Knapp. Retrovirus mediated IL-7 expression in leukemic dendritic cells generated from primary acute meylogenous leukemias enhances their functional properties. Blood 101:2184-2190 (2003)
DeMonte, L.B., M.Momo, P.Nistico, A.Anichini, F.Cavallo, M.Mariani, W.Knapp, M.LeTarte, P.G.Natali, and F.Malavasi. Murine bispecific monoclonal antibodies as immunomodulators. In: Monoclonal Antibodies 2. A.A.Epenetos Editor, Chapman & Hall Publisher, London, U.K. (2003)
Hertel, L., V.G.Lacaille, H.Strobl, E.D.Mellins, and E.S.Mocarski. Susceptibility of Immature and Mature Langerhans Cell-type Dendritic Cells to Infection and Immunomodulation by Human Cytomegalovirus. J.Virol. 77: 7563-7574 (2003)
Kopp, T., P. Lenz, C.Bello-Fernandez, R.A. Kastelein, T. S. Kupper, and G.Stingl. IL-23 Production by cosecretion ofeEndogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity. J.Immunol. 170: 5438-5444 (2003)
Lehner, M., J.Stöckl, O.Majdic, W.Knapp, K.Hüttner, T.Felzmann, and W.Holter. MHC Class II antigen signalling induces homotypic and heterotypic cluster formation of human mature monocyte derived dendritic cells in the absence of cell death. Hum. Immunol. 64:762-770 (2003)
Parolini, O., A.Weinhäusl, B.Kagerbauer, J.Sassmann, W.Holter, H.Gadner, O.A.Haas, and W.Knapp. Differential methylation pattern of the X-linked lymphoproliferative (XLP) disease gene SH2D1A correlates with the cell lineage-specific transcription. Immunogenetics 55:116-121 (2003) Säeman, M.D., C.Diakos, P.Kelemen, E. Kriehuber, M.Zeyda, G.A.Bohmig, W.H. Hörl,T.Baumruker, and G.J.Zlabinger. Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3. Am.J.Transplant. 3:1341-9 (2003)
Säeman, M.D., and G.J.Zlabinger. How to make clinical use of bacterial evasion strategies. Eur.J.Clin Invest.33(3):189-90 (2003)
Säemann, M.D., M.Zeyda, C.Diakos, A.Szekeres, G.A.Böhmig, P.Kelemen, O.Parolini, H.Stockinger, E.E.Prieschl, T.M.Stulnig, T.Baumruker, and G.J.Zlabinger. Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154. Transplantation 75 (11):1864-72 (2003)
Sanzone S., M.Zeyda, M.Saemann, M.Soncini, W.Holter, G.Fritsch, and W.Knapp, F.Condotti, T.M.Stulnig, and O.Parolini. SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients. J.Biol. Chem. 278:29593-29599 (2003)
Selenko-Gebauer, N., O.Majdic, A.Szekeres, G.Hofler, E.Guthann, U.Korthäuer, G.Zlabinger, P.Steinberger, W.F.Pickl, H.Stockinger, W.Knapp, and J.Stöckl. B7-h1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T-cell anergy. J.Immunol. 170:3637-3644 (2003)
Staffler,G., A.Szekeres, G.J.Schutz, M.D.Saemann, E.Prager, M.Zeyda, K.Drbal, G.J.Zlabinger, T.M.Stulnig, and H.Stockinger. Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts. J.Immunol.171(4):1707-14 (2003)
Stollberger, C., J.Finsterer, G.J.Zlabinger, F.Weihsengruber, S.Redtenbacher, G.Bonner, K.Herkner, and M.Deutsch. Antineutrophil cytoplasmic autoantibody-negative anti-proteinase 3 syndrome presenting as vasculitis, endocarditis, polyneuropathy and Dupuytren's contracture. J.Heart Valve Dis.12:530-4 (2003)
Strobl, H. Molecular mechanisms in dendritic cell sub-lineage development from human hematopoietic progenitor/stem cells. Int.Arch.Allergy Immunol.131: 73-79 (2003)
Wahrmann, M., M.Exner, H.Regele, K.Derfler, G.F.Kormoczi, K.Lhotta, G.J.Zlabinger, and G.A.Bohmig. Flow cytometry based detection of HLA alloantibody mediated classical complement activation. Flow cytometric based detection of HLA alloantibody mediated classical complement activation. J.Immunol Methods 275(1-2):149-60 (2003)
Zeyda,M., A.B.Szekeres, M.D.Saemann, R.Geyeregger, H.Stockinger, G.J.Zlabinger, W.Waldhäusl, and T.M.Stulnig. Suppression of T cell signaling by polyunsaturated fatty acids: selectivity in inhibition of mitogen-activated protein kinase and nuclear factor activation. J.Immunol. 170:6033-6039 (2003)
Year 2004
Bene, M.C., G.Castoldi, W.Knapp, G.M.Rigolin, L.Escribano, P.Lemez, W.D.Ludwig, E.Matutes, A.Orfao, F.Lanza and M.van't Veer on behalf of the EGIL group. CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review Leukemia 18 (3): 394-400 (2004)
Koller, H., K.Hochegger, G.J.Zlabinger, K. Lhotta, G.Mayer, and A.R.Rosenkranz. Apoptosis of human polymorphonuclear neutrophils accelerated by dialysis membranes via the activation of the complement system. Nephrol. Dial. Transplant.19:3104-11 (2004)
Madakamutil, L.T., D.Gangadharan, U.Chrtisten, C.J.Lena, Y.Wang-Zhu, A.Attinger, W.Ellmeier, M.G.von Herrath, P.Jensen, D.R.Littman and H.Cheroutre. CD8a+ primary effector cell selectively differentiate into memory CD8 T cells. Science 304:590-3 (2004)
Pfistershammer, K., O.Majdic, J.Stöckl, G.Zlabinger, S.Kirchberger, P.Steinberger, and W.Knapp. CD63, an activation-linked T cell costimulatory element. J.Immunol. 173: 6000-8 (2004)
Platzer, B., A.Jörgl, S.Taschner, B.Höcher, and H.Strobl. RelB regulates human dendritic cell subset development by promoting monocyte intermediates. Blood 104:3655-3663 (2004)
Säemann,M.D., M.Zeyda, T.M.Stulnig, G.A.Bohmig, T.Wekerle, W.H.Hörl, and G.Zlabinger. Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation. Transplant. Int. 17:481-9 (2004)
Säemann, M.D., P.Kelemen, G.A.Bohmig, W.H.Horl, and G.J.Zlabinger. Hypo-responsiveness in alloreactive T-cells by NF-kappaB inhibitor- treated dendritic cells: resistance to calcineurin inhibition Am. J. Transplant.4:1448-58 (2004)
Schmidt, U. Boucheron, N., Unger, B., and Ellmeier, W. The role of Tec family kinases in myeloid cells. Int. Arch. All. Immunol. 134, 65-78 (2004)
Schmidt, U., van den Akker, E., Parren-van Amelsvoor, M., Litos, G., de Bruijn, M., Hendriks, R.W., Ellmeier, W., Beug, H. and von Lindern, M. Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors. J. Exp. Med. 199, 785-95 (2004)
Scholz, W., B.Platzer, A.Schumich, B.Höcher, G.Fritsch, W.Knapp and H.Strobl. Initial human myeloid/dendritic cell progenitors identified by absence of myeloperoxidase protein expression. Exp.Hematol. 32:270-276 (2004)
Steinberger, P., O.Majdic, S.V.,Derdak, K.Pfistershammer, S.Kirchberger, C.Klauser, G.Zlabinger, W.F.Pickl, J.Stöckl, and W.Knapp. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J.Immunol.172:2352-2359 (2004)
Strobl, H. and W.Knapp. Myeloid cell-associated lysosomal proteins as flow cytometry markers for leukocyte lineage classification. Review J. Biol. Regul. Homeost. Agents 18:335-9 (2004)
Taniguchi, I., Ellmeier, W., and Littman, D.R. The CD4/CD8 Lineage choice: new insights into epigenetic regulation during T cell development. Adv. Immunol. 83, 55-89. (2004)
Traxler, E., E.Bayer, J.Stöckl, T.Mohr, C.Lenz, and C.Gerner. Towards a standardized human proteome database: quantitative proteome profiling of living cells. Proteomics 4:1314-1323 (2004)
Woehrl, S., R.Loewe, W.F.Pickl, G.Stingl, and S.N.Wagner. Stevens-Johnson-Syndrome after phenytoin and radiation in a patient with bronchial carcinoma – another case of EMPACT. J. Deutsch. Derm. Ges.3:39-43 (2004)
Yu, P.W., R.S.Tabuchi, R.M.Kato, A.Astrakhan, A., S.Humblet-Baron, K.Kipp, K.Chae, W.Ellmeier, O.N. Witte and D.J.Rawlings. Sustained correction of B cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood 104:1281-1290 (2004)
Year 2005
Aichberger, K.J., M.Mayerhofer, M.T.Krauth, A.Vales, R.Kondo, S.Derdak, W.F.Pickl, E.Selzer, M.Deininger, B.J.Druker, C.Sillaber, H.Esterbauer, P.Valent Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds. Cancer Res. 65:9436-9444 (2005)
Aichberger, K.J., M.Mayerhofer, M.T.Krauth, H.Skvara, S.Florian, K.Sonneck, C.Akgul, S.V.Derdak, W.F.Pickl, V.Wacheck, E.Selzer, B.P.Monia, R.Moriggl, P.Valent, and C.Sillaber. Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): Evidence for cooperative antileukemic effects of STI571 and mcl-1 antisense oligonucleotides. Blood 105:3303-3311 (2005)
Blüml S., S.Kirchberger, V.N.Botchkov, G.Krönke, K.Stuhlmeier, O.Majdic, G.J.Zlabinger, W.Knapp, B.R.Binder, J.Stöckl, N.Leitinger. Oxidized phospholipids negatively regulate dendritic cell maturation induced by Toll-like receptor and CD40. J.Immunol. 175:501-508 (2005)
Choremi-Papadopoulou H, G.C. Faure, N.Grunnet, M.Madden, B.Malenica, S.A. Misbah, E.Theodorsson, and G.J.Zlabinger. Position statement: training programme in immunology of the European Board of UEMS Medical Biopathology. Immunol. Lett. 96:305-10 (2005)
Feik, N., I.Bilic, J.Tinhofer, B.Unger, D.R. Littman and W.Ellmeier. Functional and molecular analysis of the double-positive stage-specific CD8. enhancer E8-III during thymocyte development. J.Immunol.174:1513-1524 (2005)
Geyeregger R, M.Zeyda, G.J.Zlabinger, W.Waldhausl T.M.Stulnig. Polyunsaturated fatty acids interfere with formation of the immunological synapse. J. Leukoc. Biol.77:680-688 (2005)
Huttner, K.G., S.K.Breuer, P.Paul, O.Majdic, A.Heitger, T.Felzmann Generation of potent anti-tumor immunity in mice by interleukin-12-secreting dendritic cells. Cancer Immunol.Immunother. 54:67-77 (2005)
Kirchberger, S., O.Majdic, P.Steinberger, S.Blüml, K.Pfistershammer, G.Zlabinger, L.Deszecz, E.Küchler, W.Knapp, and J.Stöckl. Human rhinoviruses inhibit the accessory function of dendritic cells by inducing Siglec-1 and B7-H1 expression. J.Immunol.175:1145-1152 (2005)
Kirsch, B.M., M.Zeyda, K.Stuhlmeier, J.grisar, J.S.Smolen, B.Watschinger, T.M.Stulnig, W.H.Hörl, G.J.Zlabinger and M.D.Säemann. The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function. Arthritis.Res.Ther. 7:R694-703 (2005)
Marquez, M.F., W.Ellmeier, V.Sanchez-Guajardo, A.A.Freitas, O.Acuto CD8 T cell sensory adaption dependent on TCR avidity for self antigens. .J.Immunol.175:7388-7397 (2005)
Mayerhofer, M., K.J.Aichberger, S.Florian, M.T.Krauth, A.W.Hauswirth, S.V.Derdak, W.R.Sperr, H.Esterbauer, O.Wagner, C.Marosi, W.F.Pickl, M.Deininger, E.Weisberg, B.J.Druker, J.D.Griffin, C.Sillaber, and P.Valent. Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells. FASEB J.19:960-962 (2005)
Saemann MD, T.Weichhart, M.Zeyda, G.Staffler, M.Schunn, K.M.Stuhlmeier, Y.Sobanov, T.M.Stulnig, S.Akira, A.von Gabain U.von Ahsen, W.H.Horl, and G.J.Zlabinger. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J. Clin. Invest. 115:468-752005 (2005)
Säemann, M.D., T.Weichhart, W.H.Hörl, and G.J.Zlabinger. Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. Eur.J.Clin.Invest. 35: 227-237 (2005)
Sarafova, S.D., B.Erman, O.Yu, F.Van Laethem, T.Guinter, S.O.,Sharrow, L.Feigenbaum, F.L.Wildt, W.Ellmeier, A.Singer. Modulation of coreceptor transcription during positive election dictates lineage fate independently of TCR/coreceptor specificity. Immunity 23:75-87 (2005)
Weichhart, T., G.J.Zlabinger, and M.D.Säemann. The multiple function of Tamm-Horsfall protein in human health and disease: a mystery clears up. Wien.Klin.Wschr.117:316-22 (2005)
Wengler, G.S., E.Brocchi, G.Lombardi, M.Bailo, P.Bonassi, D.Arienti, A.Albertini, D.Alberti, R.Zanini and O.Parolini Conditioning of neonatal pigs using low-dose chemotherapy and murine fetal tissue before murine hybridoma transplantation. Transplantation 79:349-352 (2005)
Woehrl, S., R.Loewe, W.F.Pickl, G.Stingl, S.N.Wagner. Stevens-Johnson-Syndrome after phenytoin and radiation in a patient with bronchial carcinoma - another case of EMPACT. J.Deutsch.Derm.Ges.3:39-43 (2005)
Zeyda, M., B.M.Kirsch, R.Geyeregger, K.M.Stuhlmeier, G.J.Zlabinger, W.H.Hörl, M.D.Säemann, T.M.Stulnig Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778. Transplantation 80:1105-1111 (2005)
Zeyda, M., M.Poglitsch, R.Geyeregger, J.S.Smolen, G.J.Zlabinger, W.H.Hörl, W.Waldhäusl, T.M.Stulnig, M.D.Säemann Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation. Arthritis and Rheumatism 52:2730-2739 (2005)
Zeyda M, M.D.Saemann, K.M.Stuhlmeier, D.G.Mascher, P.N. Nowotny, G.J. Zlabinger, and W.Waldhäusl, T.M.Stulnig. Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-{kappa}B activation. J. Biol. Chem. 280:14293-301 (2005)
Year 2006
Aichberger, K.J., M.Mayerhofer, A.Vales, M.T.Krauth, K.V.Gleixner, M.Bilban, H.Esterbauer, K.Sonneck, S.Florian, S.Derdak, W.F.Pickl, H.Agis, A.Falus. The CML-related oncoprotein BCR/ABL induces expressin of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells. Blood 108:3538-3547 (2006)
Aichberger K.J., M.Mayerhofer, K.V.Gleixner, M.T.Krauth, A.Gruze, W.F.Pickl, V.Wachek, E.Selzer, L.Mullauer, H.Agis, C.Sillaber, P.Valent. Identification of mcl-1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibitition of mast cell survival by mcl-1 antisense oligonucelotides and syngerism with PKC412. Blood 105:3303-3311 (2006)
Attarbaschi, A., G.Mann, M.Konig, M.Steiner, S.Strehl, A.Schreiberhuber, B.Schneider, C.Meyer, R.Marschalek, A.Borkhardt, W.F.Pickl, T.Lion, H.Gadner, OA.Haas, M.N.Dworzak Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity. Clin.Cancer Res. 12:2988-2994 (2006)
Bene, M.C., G.Castoldi, A-Derolf, R.Garand, T.Haas, T.Haferlach, W.Knapp, et al. for the EGIL Group Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases. Leukemia 20. 725-728, Letter to the Editor (2006)
Bilban, M., D.Heintel, T.Scharl, T.Wölfel, M.M.Auer, E.Porpaczy, B.Kainz, A.Krober, V.J.Carey, M.Shebata, C.Zielinski, W.Pickl, S.Stilgenbauer, A.Gaiger, O.Wagner, U.Jäger Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression. Leukemia 20:1080-1088 (2006)
Bilic I., W.Ellmeier. The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol.Lett. 108:1-9 (2006)
Bilic, I., C.Kösters, B.Unger, M.Sekimata, A.Hertweck, R.Maschek, C.B.Wilson, W.Ellmeier Negative regulation of CD8 expression via CD8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat.Immunology 7:392-400 (2006)
Blank, C., J.Kuball, S.Völkl, H.Wiendl, B.Becker, B.Walter, O.Majdic, T.F.Gajewski, M.Theobald, R.Andreesen, A.Mackensen Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro. Int.J.Cancer 119:317-327 (2006)
Derdak, S.V., H.J.Küng, V.Leb, A.Neunkirchner, K.G.Schmetterer, E.Bielek, O.Majdic, W.Knapp, B.Seed and W.F.Pickl Direct stimulation of T lymphocytes by immunosomes: virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules. Proc.Nat.Acad.Sci. 103:13144-13149 (2006)
Diakos C, Prieschl EE, Saemann MD, Bohmig GA, Csonga R, Sobanov Y, Baumruker T, Zlabinger GJ. n-Butyrate inhibits Jun NH(2)-terminal kinase activation and cytokine transcription in mast cells. Biochem Biophys Res.Commun. 2006 Oct 20;349(2):863-8. (2006)
Flicker, S., P.Steinberger, T.Ball, M.Krauth, P.Verdino, P.Valent, S.Almo, and R.Valenta Spatial clustering of the IgE epitopes on the major timothy grass pollen allergen, Ph1 p 1: Importance for allergenic activity. J.Allergy Clin.Immunol.117:1336-1343 (2006)
Gleixner, K.V., M.Mayerhofer, K.J.Aichberger, S.Derdak, K.Sonneck, A.Bohm, A.Gruze, P.Samorapoompichit, P.W.Manley, D.Fabbro, W.F.Pickl, C.Sillaber, P.Valent PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA), and evaluation of cooperative drug effects. Blood 107:752-759 (2006)
Gundacker, N., E.Bayer, E.Traxler, H.Zwickl, M.Kubicek, J.Stöckl, C.Gerner Knowledge-based proteome profiling: Conisdering identified proteins to eauate separation efficiency by 2-D PAGE. Electrophoresis 27:2712-2721 (2006)
Heinz, L.X., B.Platzer, A.Jörgl, S.Taschner, F.Göbel, and H.Strobl. Differential involvement of PU.1 and ld2 downstream of TGF-b1 during Langerhans cell commitment. Blood 107:1445-1453 (2006)
Kirchberger, S., O.Majdic, J.Stöckl. Modulation of the immune system by human rhinoviruses Int.Arch.Allergy Immunol. 142:1-10 (2006)
Kirchberger, S., H.Vetr, O.Majdic, H.Stockinger, E.Küchler, W.Knapp, J.Stöckl, Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1/ICAM-3 cell adhesion pathway in mononuclear phagocytes. Immunobiology 211:537-547 (2006)
Mann, G., A.Attarbaschi, M.Steiner, I.Simonitsch, H.Strobl, C.Urban, B.Meister, O.Haas, M.Dworzak, H.Gadner, Austrian Berlin-Frankfurt-Münster (BFM) Group Early and reliable diagnosis of non-Hodgkin lymphoma in childhood and adolescence: contribution of cytomorphology and flow cytometric immunophenotyping. Pediatr.Hematol.Oncol.23:167-176 (2006)
Mechtcheriakova D, Wlachos A, Sobanov J, Kopp T, Reuschel R, Bornancin F, Cai R, Zemann B, Urtz N, Stingl G, Zlabinger G, Woisetschlager M, Baumruker T, Billich A. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cell Signal 19:748-760 (2006)
Pfistershammer, K., C.Klauser, W.F.Pickl, J.Stöckl, J.Leitner, G.Zlabinger, O.Majdic, and P.Steinberger No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur.J.Immunol.36:1104-1113 (2006)
Pfistershammer, K., J.Stöckl, J.Siekmann, P.L.Turecek, H.P.Schwarz, B.M.Reipert Recombinant facor VIII and factor VIII-von Willebrand factor complex do not present danger signals for human dendritic cells. Thromb.Haemostasis 96:309-316 (2006)
Sonneck, K., S.Florian, A.Böhm, M.T.Krauth, R.Kondo, A.W.Hauswirth, K.V,Gleixner, K.J.Aichberger, S.Derdak, W.F.Pickl, W.R.Sperr, L.B.Schwartz, P.Valent Evaluation of biologic activity of tryptase secreted from blast cells in acute myeloid leukemia. Leuk.Lymphoma 47:897-906 (2006)
Strobl, H., B.Platzer, A.Jörgl, S.Taschner, L.Heinz, and P.Reisner. Growth Factors. Handbook of Dendritic Cells - Biology, Diseases and Therapies. Steinkasserer, Lutz (Eds). Wiley-VCH, Vol.1:27-52 (2006)
Swan, C.H., B.Bühler, P.Steinberger, M.P.Tschan, C.F.Barbas 3rd, B.E.Torbett T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery Gene Therapy 13:1480-1492 (2006)
Zeyda M, Geyeregger R, Poglitsch M, Weichhart T, Zlabinger GJ, Koyasu S, Horl WH, Stulnig TM, Watschinger B, Saemann MD. Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-{kappa}B in immunological synapse formation. J Leukoc Biol. 81:319-327 (2006)
Year 2007
Aichberger K.J, M.Mayerhofer, K.V.Gleixner, M.T.Krauth, A.Gruze, W.F.Pickl,V.Wacheck, E.Selzer, L.Mullauer, H.Agis, C.Sillaber, P.Valent .Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412. Blood 109(7):3031-3041 (2007)
Attarbaschi A., G.Mann, A.Schumich, M.Konig, W.F.Pickl, O.A.Haas, H.Gadner. M.N.Dworzak. CD44 deficiency is a consistent finding in childhood Burkitt's lymphoma and leukemia. Leukemia 21(5):1110-1113 (2007)
Bilic I. and W.Ellmeier. The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol.Lett. 108:1-9 (2007)
Gartner W., G.Vila, T.Daneva, A.Nabokikh, F.Koc-Saral, A.Ilhan, O.Majdic, A.Luger, L.Wagner. New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog. Am.J.Physiol Endocrinol. Metab. 293(1):E347-354 (2007)
Geyeregger R, M.Zeyda, W.Bauer, E.Kriehuber, M.D.Saemann, G.J.Zlabinger, D.Maurer, T.M.Stulnig. Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin bundling protein fascin. Blood 109:4288-4295 (2007)
Gleixner, K.V., L.Rebuzzi, M.Mayerhofer, A.Gruze, E.Hadzijusufovic, K.Sonneck, A.Vales, M.Kneidinger, P.Samorapoompichit, T.Thaiwong, W.F.Pickl, V.Yuzbasiya-Gurkan, C.Sillaber, M.Willmann, P.Valent. Synergistic antiproliferative effects of KIT tyrosine kinase inhibitors on neoplastic canine mast cells. Exp.Hematol. 35:1510-1521 (2007)
Gleixner, K.V., M.Mayerhofer, K.Sonneck, A.Gruze, P.Samorapoomichit, C.Baumgartner, F.Y. Lee, K.J.Aichberger, P.W.Manley, D.Fabbro, W.F.Pickl, C.Sillaber, P.Valent. Synergistic growth-inhibitory effects of two tyrosine kinase inhibitors, dasatinib and PKC412, on neoplastic mast cells expressing the D816V-mutated oncogenic variant KIT. Haematologica 92:1451-1459 (2007)
Hantschel, O., U.Rix, U.Schmidt, T.Burckstummer, M.Kneidinger, G.Schutze, J.Colinge, K.L.Bennet, W.Ellmeier, P.Valent, G.Superti-Furga. The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. PNAS 104:13283-13288 (2007)
Hochegger K., P.Eller, J.M.Huber, D.Bernhard, G.Mayer, G.J.Zlabinger, A.R.Rosenkranz. Expression of granzyme A in human polymorpho-nuclear neutrophils. Immunology 121:166-173 (2007)
Jörgl, A., B.Platzer, S.Taschner, L.X.Heinz, B.Höcher, P.M.Reisner, F.Göbel, H.Strobl. Human Langerhans cell activation triggered in vitro by conditionally expressed MKK6 is counter-regulated by the downstream effector RelB. Blood 109:185-193 (2007)
Kirchberger, S., O.Majdic. J.Stöckl. Modulation of the immune system by human rhinoviruses. Int.Arch.Allergy Immunol. 142:1-10 (2007)
Koesters C., B.Unger, I.Bilic, U.Schmidt, S.Bluml, B.Lichtenberger, M.Schreiber, J.Stöckl, W.Ellmeier Regulation of dendritic cell differentiation and subset distribution by the zinc finger protein CTCF. Immunol Lett. 109(2):165-174 (2007)
Kondo R, K.V.Gleixner, M.Mayerhofer, A.Vales, A.Gruze, P.Samorapoompichit, K.Greish, M.T.Krauth, K.J.Aichberger, W.F.Pickl, H.Esterbauer, C.Sillaber, H.Maeda, P.Valent Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells. Blood 110(2):661-669 (2007)
Küng, H.J.,V.Leb, D.Haiderer, G.Raposo, C.Thery, S.V.Derdak, K.G.Schmetterer, A.Neunkirchner, C.Sillaber, W.F.Pickl. General strategy for decoration enveloped viruses with functionally active lipid-modified cytokines. J.Virol. 81:8666-8676 (2007)
Mechtcheriakova D., A.Wlachos, J.Sobanov, F.Bornancin, G.Zlabinger, T.Baumruker FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3. FEBS Lett. 581(16):3063-3068 (2007)
Mechtcheriakova D., A.Wlachos, J.Sobanov, T.Kopp, R.Reuschel, F.Bornancin, R.Cai, B.Zemann, N.Urtz, G.Stingl, G.Zlabinger, M.Woisetschläger, T.Baumruker, A.Billich. Sphingosine 1-phosphatase phosphatase 2 is induced during inflammatory response. Cell Signal 19:748-760 (2007)
Park, J.H., S.Adoro, P.J.Lucas, S.D.Sarafova, A.S.Alag, L.L.Doan, B.Erman, X.Liu, W.Ellmeier, R.Bosselut, L.Feigenbaum, A.Singer. "Coreceptor tuning": a cytokine signals transcriptionally tailor CD8 expression to the self-specificity of the TCR. Nat.Immunol. 8: 1049-1059 (2007)
Rebuzzi, L., M.William, K.Sonneck, K.V.Gleixner, S.Florian, R.Kondo, M.Mayerhofer, A.Vales, A.Gruze, W.F.Pickl, J.G.Thalhammer, P.Valent. Detection of vascular endothelial growth factor (VEGF) and VEGF receptors Flt-1 and KDR in canine mastocytoma cells. Vet.Immunol. Immunopathol. 115: 320-333 (2007)
Stefanova T., N.Nikolova, A Michailova, I.Mitov, I.Iancov, G.J.Zlabinger, H.Neychev. Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment. Microbes Infect. 9(1):7-14 (2007)
Taschner S., C.Koesters, B.Platzer, A.Jorgl, W.Ellmeier, T.Benesch, H.Strobl. Downregulation of RXRa expression is essential for neutrophil development from granulocyte/monocyte progenitors. Blood 109:971-979 (2007)
Zeyda M., D. Farmer, J.Todoric, O.Aszman, M.Speiser, G.Gyori, G.J.Zlabinger, T.M.Stulnig. Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int.J.Obes. 31:1420-1428 (2007)
Zeyda M., R.Geyeregger, M.Poglitsch, T. Weichhart, G. Zlabinger, S.Koyasu, W.H.Horl, T.M.Stulnig, B.Watschinger, M.D.Saemann. Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation. J Leukoc Biol. 81(1):319-27 (2007)
Year 2008
Baumgartner C, K.V.Gleixner, B.Peter, V.Ferenc, A.Gruze, L.L.Remsing Rix, K.L. Bennett, P.Samorapoompichit, F.Y.Lee, W.F.Pickl, H.Esterbauer, C.Sillaber, G.Superti-Furga, P.Valent. Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFR alpha. Exp.Hematol. 36:1244-1253 (2008)
Blüml, S., B.Rosc, A.Lorincz, S.Kirchberger, O.Oskolkova, V. Bochkov, O.Majdic, E.Ligeti, J.Stöckl. The oxidation state of phospholipids controls oxidative burst formation in human neutrophil granulocytes. J.Immunology 181:4347-4353 (2008)
Flicker, S., P.Steinberger, P.B.Eibensteiner, S.Lebecque, D.Kraft, P.Valenta. Molecular characterization of a human immunoglobulin G4 antibody specific for the major birch pollen allergen, Bet v 1. Clin.Exp.Allergy 38:365-373 (2008)
Greinix, H.T., D.Pohlreich, M. Kouba, M, U.Körmöczi, I.Lohmann, K.Feldmann, C.Zielinski, W.F.Pickl. Elevated numbers of immature/transitional CD21-B lymphocytes and deficiency of memory CD27+ B cells identify patients with active chronic graft-versus-host disease. Biol.Blood Marrow Transplant 14:208-19 (2008)
Hadzijusufovic E, L.Rebuzzi , K.V.Gleixner, V.Ferenc, B.Peter, R.Kondo, A.Gruze, M.Kneidinger. M.T.Krauth, M.Mayerhofer, P.Samorapoompichit, K.Greish, A.K.Iyer, W.F.Pickl, H.Maeda, M.Willmann, P.Valent. Targeting of heat-shock protein 32/heme oxygenase-1 in canine mastocytoma cells is associated with reduced growth and induction of apoptosis. Exp.Hematol. 36:1461-1470 (2008)
Hölzl, M.A., J.Hofer, P.Steinberger, K.Pfistershammer, G.J.Zlabinger. Host microbial proteins as endogeneous imunomodulators. Immunol.Letters 119: 4-11 (2008)
Huber, J., F.W.Kiefer, M.Zeyda, B.Ludvik, G.R.Silberhumer, G.Prager, G.J.Zlabinger, T.M.Stulnig. CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. J.Clin.Endocrin.Metab.93:3215-3221 (2008)
Ilhan A, W.Gartner, A.Nabokikh, T.Daneva, O. Majdic, G.Cohen, G.A.Böhmig, W.Base, W.H.Hörl, L.Wagner: Localization and characterization of the novel protein encoded by C20orf3. Biochem.J. 414:485-495 (2008)
Jahn-Schmid B, P.Sirven, V.Leb, W.F.Pickl, G.F.Fischer, G.Gadermaier, M.Egger, C.Ebner, F.Ferreira, B.Maillére, B.Bohle. Characterization of HLA class II/peptide-TCR interactions of the immunodominant T cell epitope in Art v 1, the major mugwort pollen allergen. J.Immunol. 181:3636-3642 (2008)
Kirchberger S, O.Majdic, S.Blüml , C.Schrauf, J.Leitner , C.Gerner , W.Paster , N.Gundacker, M.Sibilia, J.Stöckl. The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells. Blood 112:1240-1248 (2008)
Kneidinger, M., U.Schmidt, U.Rix, K.V.Gleixner, A.Vales, C.Baumgartner, C.Lupinek, M.Weghofer, K.L.Bennett, H.Hermann, A.Schebesta, W.R.Thomas, S.Vrtala, R.Valenta, F.Y.Lee, W.Ellmeier, G.Superti-Furga, P.Valent. The effects of dasatinib on IgE-receptor-dependent activation and histamine release in human basophils. Blood 111:3097-3107 (2008)
Kober J., J.Leitner, C.Klauser, R.Woitek, O.Majdic, J.Stöckl, D.Herndler-Brandstetter, B.Grubeck-Loebenstein, B.M.Reipert, W.F.Pickl, K.Pfistershammer, P.Steinberger. The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells. Eur.J.Immunol .38:2678-2688 (2008)
Kuzmina, Z., H.T.Greinix, R.Knobler, N.Worel, M.Jouba, R.Weigl, U.Körmöczi, A.Rottal, D.Pohlreich, C.Zielinski, W.F.Pickl Proportions of immature CD19+CD21- B lymphocytes predict the response to extracorporel photopheresis in patients with chronic graft-versus-host disease. Blood 114:744-746 (2009)
Leb, V.M., B.Jahn-Schmid, K.G.Schmetterer, H.J.Küng, D.Haiderer, A.Neunkirchner, G.F.Fischer, K.Nissler, A.Hartl, J.Thalhammer, B.Bohle, B.Seed, W.F.Pickl. Molecular and functional analysis of the antigen receptor of Art v-1-specific helper T lymphocytes. J.Allergy Clin.Immunol. 121:64-71 (2008)
Mayerhofer, M., K.V.Gleixner, J.Mayerhofer, G.Hoermann, E.Jaeger, K.J.Aichberger, R.G.Ott, K.Greish, H.Nakamura, S.Derdak, P.Samorapoompichit, W.F.Pickl, V.Sexl, H.Esterbauer, I.Schwarzinger, C.Sillaber, H.Maeda, P.Valent. Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood 111:2200-2210 (2008)
Melcher,M., B.Unger, U.Schmidt., I.A.Rajantie, K.Alitalo, W.Ellmeier. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J.Immunol.180:8048-8056 (2008)
Neziri, D., Ilhan, A, Maj, M., Majdic, O., Baumgartner-Parzer, S., Cohen, G., Base, W., Wagner, L. Cloning and molecular characterization of Dashurin encoded by C20orf116, a PCI-domain containing protein. Biochim Biophys Acta. 2009 Dec (2009)
Pfistershammer K., C.Klauser, J.Leitner, J.Stöckl, O.Majdic, T.Weichhart, Y.Sobanov, V.Bochkov, M.Säemann, G.Zlabinger, P.Steinberger. Identification of the scavenger receptors SREC-I, Cla-1 (SR-BI), and SR-AI as cellular receptors for Tamm-Horsefall protein. J.Leukocyte Biology 83:131-138 (2008)
Raberger J., N.Boucheron, S.Sakaguchi, J.M.Penninger, W.Ellmeier. Impaired T-cell development in the absence of Vav1 and Itk. Eur.J.Immunol. 38: 3530-3542 (2008)
Raberger J., A.Schebesta, S.Sakaguchi, N.Boucheron, K.E.Blomberg, A.Berglöf, T.Kolbe, C.I.Smith CI, T.Rülicke, W.Ellmeier. The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells. PNAS 105:17919-17924 (2008)
Sagmeister, S., M.Eisenbauer, C.Pirker, T.Mohr, K.Holzmann, H.Zwickl, C.Bichler, D.Kandioler, F. Wrba, W.Mikulit, C.Gerner, M.Shehata, O.Majdic, B.Streubel, W.Berger, M.Micksche, K.Zatloukal, R.Schulte-Hermann, B.Grasl-Kraupp. New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcino-genesis. Brit.J.Cancer 99:151-159 (2008)
Seyerl, M., S.Blüml, S.Kirchberger, V.N.Bochkov, O.Oskolkova, O.Majdic, J.Stöckl. Oxidized phospholipids induce anergy in human peripheral blood T cells. Eur.J.Immunol. 38:778-787 (2008)
Shinohara, M., T.Koga, K.Okamoto, S.Sakaguchi, K.Arai, H.Yasuda, T.Takai, T.Kodama, T.Morio, R.S.Geha, D.Kitamura, T.Kurosaki, W.Ellmeier,H.Takayanagi.Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132: 794-806 (2008)
Sillaber, C., M.Mayerhofer, A.Böhm, A.Vales, A.Gruze, K.J.Aichberger, H.Esterbauer, M.Pfeilstöcker, W.R.Sperr, W.F.Pickl, O.A.Haas, P.Valent. Evaluation of antileukemic effects of rapamycin in patients with imatinib-resistant chronic myeloid leukaemia. Eur.J.Clin.Invest. 38:43-52 (2008)
Sobal, G., E.J.Menzel, H.Sinzinger Radiolabeling procedure quality control and stability of (99m) Tc-labeled chondroitin sulfate: A new approach of targeting osteoarthritis Appl.Radiat.Isotopes 66:415-420 (2008)
Strehl, S., K.Nebral, M.König, J.Harbott, H.Strobl, R.Ratei, S.Struski, B.Bielorai, M.Lessard, M.Zimmermann, O.A.Haas, S.Izraeli. ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations. Clinical Cancer Research 14:977-983 (2008)
Zebedin E., O.Simma, C.Schuster. E.M.Putz, S.Fajmann, W.Warsch, E.Eckelhart, D.Stoiber, E.Weisz, J.A.Schmid, W.F.Pickl, C.Baumgartner, P.Valent, R.P., Piekorz, M.Freissmuth, V.Sexl. Leukemic challenge unmasks a requirement for PI3K{delta} in NK-cell-mediated tumor surveillance. Blood 112:4655-4664 (2008)Year 2009
Aichberger, K.J., Gleixner, K.V., Mirkina, I., Cerny-Reiterer, S., Peter, B., Ferenc, V., Kneidinger, M., Baumgartner, C., Mayerhofer, M., Gruze, A., Pickl, W.F., Sillaber, C., Valent, P. Identification of pro-apoptotic Bim as a tumor suppressorin neoplastic mast cells: role of KIT D816V and effects of various targeted drugs. Blood114: 5342-5351(2009)
Blomberg, K.E., N.Boucheron, J.M.Lindvall, L.Yu, J.Raberger, A.Berlöf, W.Ellmeier, C.E.Smith. Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells. BMC Genomics 10:233 (2009)
Blüml, S., Zupkovitz, G., Kirchberger, S., Seyerl, M., Bochkov, V.N., Stuhlmeier, K., Majdic, O., Zlabinger, G.J., Seiser, C., Stöckl, J. Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids. Blood 114:5481-5489 (2009)
Bochkov, V.N., O.V.Oskolkova, K.G.Birukov, A.L.Levonen, C.J.Binder, J.Stöckl. Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal, in press (2009)
Bohm, A., K. J. Aichberger, M. Mayerhofer, H. Herrmann, S. Florian, M. T. Krauth, S. Derdak, P. Samorapoompichit, K. Sonneck, A. Vales, K. V. Gleixner, W. F. Pickl, W. R. Sperr, P. Valent. Targeting of mTOR is associated with decreased growth and decreased VEGF expression in acute myeloid leukaemia cells. Eur.J.Clin.Invest. 39:395-405 (2009)
Choremi-Papadopoulou H., G.C. Faure, B.Malenica, S.A.Misbah, G.J.Zlabinger. Position statement: Assessment strategy for implementation of the mmunology curriculum of the European Board of UEMS Medical Biopathology .Immunol Lett. 125:59-64 (2009)
Funk M, Karl D, Georgopoulos M, Benesch T, Sacu S, Polak K, Zlabinger GJ, Schmidt-Erfurth U. Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab. Ophthalmology. 2009 Dec;116(12):2393-9 (2009)
Funk, M., G.Schmidinger, M-.Bolz, N.Maar, T.Benesch, G.J.Zlabinger, U.Schmidt-Erfurth. Angiogenic and inflammatory markers in intraocular fluid of eye with diabetic macular edema and the influence of therapy with Bevacizumab. Ophthalmology, in press (2009)
Funk, M., K.F.Kriechbaum, F.Prager, T.Benesch, M.Georgopoulos, G.J. Zlabinger, U.Schmidt-Erfurth. Intraocular concentrations of growth factors and cytokines in retinal vein occlusion and the effect of therapy with Bevacizumab. Invest. Ophthalmol.50(3):1025-1032 (2009)
Geyeregger R., M.Shehata, M.Zeyda, F.W.Kiefer, K.M.Stuhlmeier, E.Porpaczy, G.J.Zlabinger, U.Jäger, T.M.Stulnig. Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes. J.Leukoc.Biol.86:1039-1048 (2009)
Gleixner, K. V., M. Mayerhofer, A. Vales, A. Gruze, G. Hormann, S. Cerny-Reiterer, E. Lackner, E. Hadzijusufovic, H. Herrmann, A. K. Iyer, M. T. Krauth, W. F. Pickl, B. Marian, R. Panzer-Grumayer, C. Sillaber, H. Maeda, C. Zielinski, P. Valent. Targeting of Hsp32 in Solid Tumors and Leukemias: A Novel Approach to Optimize Anticancer Therapy. Curr Cancer Drug Targets 9:675-689 (2009)
Göbel, F., S.Taschner, J.Jurkin, S.Witzel, C.Vaculik, S.Richter, D.Kneidinger, C.Mühlbacher, C.Bieglmayer, A.Bürger-Elbe, H.Strobl. Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation. Blood 114:3813-3821 (2009)
Gundacker N.C., V.J.Haudek, H.Wimmer, A.Slany, J.Griss, V.Bochkov, C.Zielinski, O.Wagner, J.Stöckl, C,Gerner. Cytoplasmic proteome and secretome profiles of differently stimulated human dendritic cells. J Proteome Res. 8:2799-2811 (2009)
Hadzijusufovic, E., B. L.Peter, C.Rebuzzi, K.V.Baumgartner, A.Gleixner, A. Gruze, T. Thaiwong, W. F. Pickl, V. Yuzbasiyan-Gurkan, M. Willmann, P. Valent. Growth-inhibitory effects of four tyrosine kinase inhibitors on neoplastic feline mast cells exhibiting a Kit exon 8 ITD mutation. Vet.Immunol. Immuno-pathol., in press (2009)
Köprülü, A.D. and W. Ellmeier. The Role of Tec Family Kinases in Mononuclear Phagocytes. Critical Reviews in Immunology 29: 317-333 (2009).
Kuzmina, Z., H.T.Greinix, R.Knobler, N.Worel, M.Jouba, R.Weigl, U.Körmöczi, A.Rottal, D.Pohlreich, C.Zielinski, W.F.Pickl. Proportions of immature CD19+CD21- B lymphocytes predict the response to extracorporel photopheresis in patients with chronic graft-versus-host disease. Blood 114:744-746 (2009)
Leb, V.M., B.Jahn-Schmid, H.J.Küng, K.G.Schmetterer, D.Haiderer, A., Neunkirchner, G.F.Fischer, A.Hartl, J.Thalhamer, P.Steinberger, B.Bohle, B.Seed, W.F.Pickl. Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules.J.Allergy Clin.Immunol. 124:121-128 (2009)
Leitner J, Grabmeier-Pfistershammer K, Steinberger P. Receptors and ligands implicated in human T cell costimulatory processes. Immunol Lett. 2009 Nov 24 (2009)
Leitner, J., Klauser, C., Pickl, W.F., Stöckl, J., Majdic, O., Bardet A.F., Kriel, D.P., Dong, C., Yamazaki, T., Zlabinger, G., Pfistershammer, K., Steinberger, P. B7-H3 is a potent inhibitor of human T cell activation: no evidence for B7-H3 and TREML2 interaction. Eur.J.Immunol. 39:1754-1764 (2009)
Muhammad A., H.B.Schiller, F.Forster, P.Eckerstorfer, R.Geyeregger, V.Leksa, G.J.Zlabinger, M.Sibilia, A.Sonnleitner, W.Paster, H.Stockinger. Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome. J.Immunol. 182:7672-7680 (2009)
Pfistershammer, K., A.Lawitschka, C.Klauser, J.Leitner, R.Weigl, M.H.Heemskerk, W.F.Pickl, O.Majdic, G.A.Böhmig, G.F.Fischer, H.T.Greinix, P.Steinberger. Allogeneic disparities in immunoglobuline-like transcript 5 (ILT5) induce potent antibody responses in hematopoietic stem cell transplant recipients. Blood 114:2323-2332 (2009)
Platzer, B., S.Richter, S., D.Kneidinger, D.Waltenberger, M.Woisetschläger, H.Strobl. Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells. J.Immunol. 183:66-74 (2009)
Prucker, C., A.Attarbaschi, C.Peters, M.N.Dworzak, U.Pötschger, C.Urban, F.M.Fink, B.Meister, K.Schmitt, O.A.Haas, H.Gadner, G.Mann; Austrian Berlin-Frankfurt-Münster (BFM) Study Group (+ 36 Collaborators, among them W.F.Pickl). Induction death and treatment-related mortality in first remission of children with acute lymphoblastic leukemia: a population-based analysis of the Austrian Berlin-Frankfurt-Münster study. Group. Leukemia 23 (7):1264-1269 (2009)
Regelsberger, G., R.Höftberger, W.F.Pickl, G.J.Zlabinger, U.Körmöczi, U.Salzer-Muhar, D.Luckner, O.A.Bodamer, J.A.Mayr, W.H.Muss, H.Budka, H.Bernheimer. Danon disease: Case report and detection of new mutation. J.Inherit.Metab.Dis. in press (2009)
Reismüller B., A.Attarbaschi, C.Peters, M.N.Dworzak, U.Pötschger, C.Urban, F.M.Fink, B.Meister, K.Schmitt, K.Dieckmann, G.Henze, O.A.Haas, H.Gadner, G.Mann: Austrian Berlin-Frankfurt-Münster (BFM) Study Group (+ 37 Co-Workers, among them W.F.Pickl). Long-term outcome of initially homogenously treated and relapsed childhood acute lymphoblastic leukaemia in Austria--a population-based report of the Austrian Berlin-Frankfurt-Münster (BFM) Study Group. Brit.J.Haematol. 144:559-570 (2009)
Schmidt, U., A.Abramova, N.Boucheron, E.Eckelhart,, A.Schebesta, I.Bilic, M.Kneidinger, B.Unger, M.Hammer, M.Sibilia, P.Valent, W.Ellmeier. The protein tyrosine kinase Tec regulates mast cell function. 2009. European Journal of Immunology 39:3228-3238 (2009)
Schrauf, C., S. Kirchberger, O. Majdic, M. Seyerl, G. Zlabinger, K. Stuhlmeier, M. Sachet, J. Seipelt, J. Stöckl. The ssRNA genome of human rhinovirus induces a type-I IFN response but fails to induce maturation in human monocyte-derived dendritic cells. J Immunol. 183: 4440-4448 (2009)
Simma O, E.Zebedin, N.Neugebauer, C.Schellack, A.Pilz, S.Chang-Rodriguez, K.Lingnau, E.Weisz, E.M.Putz, W.F.Pickl, T., Felzmann, M.Müller, T.Decker , V.Sexl, D.Stoiber. Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Cancer Res. 69: 203-211 (2009)
Year 2010
Gleixner, K.V., Ferenc, V., Peter, B., Gruze, A., Meyer, R.A., Hadzijusufovic, E., Cerny-Reiterer, S., Mayerhofer, M., Pickl, W.F., Sillaber, C., Valent, P. Polo-like Kinase 1 (Plk1) as a Novel Drug Target in Chronic Myeloid Leukemia: Overriding Imatinib Resistance with the Plk1 Inhibitor BI 2536. Cancer Res. Feb. (2010)
Haidinger, M., Hecking, M., Weichhart, T., Poglitsch, M., Enkner, W., Vonbank, K., Prayer, D., Geusau, A., Oberbauer, R., Zlabinger, G.J., Soleiman, A., Hörl, W.H., Säemann, M.D. Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity. Transplant. Int. Jan, in press (2010)
Jurkin, J., Y. M. Schichl, R. Koeffel, T. Bauer, S. Richter, S. Konradi,
B. Gesslbauer H. Strobl. miR-146a is differentially expressed by myeloid
dendritic cell subsets and desensitizes cells to TLR2-dependent
activation. J Immunol, in press
Kueng ,H.J., Manta, C., Haiderer, D., Leb, V.M., Schmetterer, K.G., Neunkirchner, A., Byrne, R.A., Scheinecker, C., Steinberger, P., Seed, B., Pickl, W.F. Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions. FASEB Jan.2010 (2010)
Seyerl, M., Kirchberger, S., Majdic, O., Seipelt, J., Jindra, C., Schrauf, C., Stöckl, J. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol. 40:321-329 (2010)
Steiner, M., Attarbaschi, A., Dworzak, M., Strobl H, Pickl W, Kornmüller R, Haas O, Gadner H, Mann G; On behalf of the Austrian Berlin-Frankfurt-Münster (BFM) Study Group. Cytochemically Myeloperoxidase Positive Childhood Acute Leukemia With Lymphoblastic Morphology Treated as Lymphoblastic Leukemia. J.Pediatr. Hematol. Oncol.32:e4-7 (2010)
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