Winfried Pickl - Cellular Immunology and Immune Hematology

T cell activation is the result of a sustained antigen-specific interaction of a T lymphocyte with a professional antigen-presenting cell (pAPC) in a secondary lymphatic tissue. The detailed description of the molecular and functional events within the immunological synapse formed by T cells and pAPC is one of the keys to the better understanding of adaptive immune responses and their modulation. Model systems in which the immunological synapse (Fig. 1) can be rebuilt with
receptors relevant for human diseases shall enable us to study the pathophysiology of allergies, autoimmune and infectious diseases as well as cancer in greater detail and may thus lead to novel strategies for their cure.

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