Welcome to the Division of Immunobiology

Our Research

T lymphocytes (T cells) are key cellular players in the regulation and execution of immune responses in response to foreign pathogens. However, dysregulation of effector T cell function is linked with the development of immune-mediated diseases such as autoimmunity or allergy. Thus, the activity of T cells has to be tightly controlled. Our long-term research interest is to characterize molecular mechanisms that regulate the development and function of T lymphocytes. We made important contributions to the transcriptional control of Cd8 gene expression and identified that the transcription factor MAZR is an important regulator of CD8 expression as well as of CD4/CD8 lineage development. Moreover, we are interested in elucidating the roles of histone deacetylases (HDACs) in T cells and e.g. we recently identified that CD4+ T cell lineage integrity is regulated by HDAC1 and HDAC2. Further, we have also a long-standing interest in revealing the role of Tec family kinases in the regulation of immune responses. With our studies we aim to provide important and medical relevant insight into the regulation of T cell-mediated immunity.

In ongoing studies we address topics like:

• Transcriptional control of CD4/CD8 cell fate choice.
• Transcription factor networks regulating peripheral T cell function.
• Maintenance of T cell lineage identity and integrity.
• Characterization of signaling pathways modulating Th differentiation.

The experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and moleculr approaches, retroviral.mediated gene transduction into hematopoietic stem cells, next generation sequencing and mouse molecular genetics tools.


News

++ 11/2017 - New publication of our lab on the role of NCOR1 during T cell development <link>
++ 10/2017 - 2 FWF-funded PhD positions available <link>
++ 10/2017 - Nicole Boucheron received a stand alone FWF project
++ 10/2017 - Special issue of FEBS letters on "Immunity & Metabolism" published (edited by Laszlo Nagy and Wilfried Ellmeier) <link>
++ 09/2017 - New publication of our lab about the role of HDAC1 in EAE in the Journal of Autoimmunity <link>
++ 08/2017 - Patricia Hamminger received a DOC fellowship of the Austrian Academy of Sciences <link>

Institute of Immunology (IFI)
Center for Pathophysiology, Infectiology and Immunology (CePII)

The Division of Immunobiology is part of the Institute of Immunology (IFI), which has been established in the year 1967. IFI is part of the Center for Pathophysiology, Infectiology and Immunology, Immunology (CePII), which hosts most of the research laboratories of the preclinical medical school working in the field of pathophysiology, allergy, infectiology and immunology.


Immunology Research (IRC)

The Immunology Research Cluster (IRC) is a network of more than 80 research groups at the Medical University of Vienna with a strong research focus on Allergy, Inflammation & Infection. The overall aim of IRC is to strengthen the research environment and support in the field of Immunology and to foster translational approaches for the benefit of the patient. In addition, IRC members are dedicated at providing excellent research and training opportunities for PhD students and postdoctoral fellows.

Doctoral program "Inflammation & Immunity"(IAI)

We are part of the Austrian Science Fund (FWF)/MedUni Wien doctoral program "Inflammation and Immunity" (IAI). IAI is an international PhD and MD/PhD Program focusing on Inflammation and Immunity that integrates basic, applied and clinical sciences to provide comprehensive and cutting-edge research training.

Marie Curie Training Network "ENLIGHT-TEN"

We are participating in the "European Network Linking Informatics and Genomics of Helper T cells - ENLIGHT-TEN", which is a Marie Sklodowska-Curie Innovative Training Network (ITN-ETN) funded in the framework of the HORIZON 2020 program. The mission of ENLIGHTTEN is to provide cross-disciplinary training in T cell immunology and big data analysis in order to train a new generation of researchers to exploit the power of emerging technological platforms. More information can be found <here>.


Alliance for Biomedical Research in Europe

The Alliance for Biomedical Research in Europe (BioMed Alliance) is the result of a unique initiative of leading European medical societies that together include more than 400,000 researchers and health professionals. The BioMed Alliance was created in 2010 to gather strength across different disciplines and areas in biomedical and health research at European level.



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