Division of
Medical Biotechnology
Department of Pathophysiology and Allergy Research

Welcome

Welcome to the Division of Medical Biotechnology. We are located at the Department of Pathophysiology and Allergy Research of the Medical University of Vienna.

Groups

Heimo Breiteneder
Biotechnology and Biochemical Diagnostics
Merima Bublin
Allergen Biology
Karin Hoffmann-Sommergruber
Molecular Allergology
Christian Radauer
Biochemistry and Bioinformatics

Research News

2021-11-02

Birch pollen allergic patients have IgE and IgG antibodies binding to diverse patterns of conformational epitopes on the major allergen, Bet v 1

Birch pollen is one of the most important elicitors of respiratory allergy. In this study, which was conducted by Stefanie Schmalz from Christian Radauer's group and published in the Journal of Allergy and Clinical Immunology, we showed that the epitope recognition profiles of Bet v 1-sensitized patients are polyclonal and highly individual and differ between Bet v 1-specific IgE, IgG1 and IgG4. Data on the epitope recognition profiles of allergen-specific IgE and IgG may aid in elucidating the molecular basis of varying clinical outcomes of sensitization to Bet v 1 with respect to plant food allergy, for monitoring immunological changes during allergen immunotherapy (AIT) and for designing hypoallergenic Bet v 1 derivatives for safer and more effective types of AIT.

Publication details:

Schmalz S, Mayr V, Shosherova A, Gepp B, Ackerbauer D, Sturm G, Bohle B, Breiteneder H, Radauer C:
Isotype-specific binding patterns of serum antibodies to multiple conformational epitopes of Bet v 1.
J Allergy Clin Immunol 2022, (in press) [PubMed] [Full Text]

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News

2021-07-22

Graduation of Katharina Schwertner

Afte defending her thesis entitled In vitro model to investigate the effects of advanced glycation end products (AGEs) on the intestinal epithelium, Katharina Schwertner from Karin Hoffmann-Sommergruber's lab graduated with a master's degree in biotechnology at the University of Natural Resources and Life Sciences Vienna. Congratulations!

2021-07-10:

Paul Ehrlich Award for Heimo Breiteneder

We congratulate Heimo Breiteneder for receiving the prestigious Paul Ehrlich Award for Experimental Research, granted by the European Academy of Allergy and Clinical Immunology (EAACI). With this award, the EAACI honoured Heimo's breakthrough achivements in moelular allergy research, starting in 1989 with the molecular cloning of the major birch pollen allerrgen, Bet v 1, the first plant allergen sequenced and expressed as a recombinant protein, and continuing until today with works on the molecular and immunological characterization of allergens from pollen, natural rubber latex and food.

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Contact info

Address
Division of Medical Biotechnology
Department of Pathophysiology and Allergy Research
EBO-3Q
Währinger Gürtel 18-20 1090 Vienna, Austria
Phone: +43 1 40400 51120
Fax: +43 1 40400 51300
Head of the Division
Heimo Breiteneder
E-mail: heimo.breiteneder@muv.ac.at
Administration
Natascha Hendler
E-mail: petra-natascha.hendler@muv.ac.at
Webmaster
Christian Radauer
E-mail: christian.radauer@muv.ac.at

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