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Jahn-Schmid, B., M. Hauser, N. Wopfner, P. Briza, U. E. Berger R. Asero, C. Ebner, F. Ferreira, and B. Bohle. Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6. J Immunol. 2011, in press
Kitzmüller, C., B. Nagl, S. Deifl, C. Walterskirchen, B. Jahn- Schmid, G. J. Zlabinger, and B. Bohle. Human blood basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. Allergy 2011, in press
Neunkirchner, A ., V. M. Leb-Reichl, K. G. Schmetterer, S. Mutschlechner, H. J. Kueng, D. Haiderer, K. Schuch, M. Wallner, B. Jahn-Schmid, B. Bohle and W. F. Pickl . Human TCR Transgenic Bet v 1-Specific Th1 Cells Suppress the Effector Function of Bet v 1-Specific Th2 Cells. J Immunol. 2011, in press
Schulten, V., B. Nagl, E. Scala, M. L. Bernardi, A. Mari, M. A. Ciardiello, I. Lauer, S. Scheurer, P. Briza, A. Jürets, F. Ferreira, B. Jahn-Schmid, G. F. Fischer and B. Bohle. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy Aug;66(8):1005-13. doi: 10.1111/j.1398-9995.2011.02567.x , 2011 Van Hemelen, D., J. N. Oude Elberink, B. Bohle, J. Heimweg, M. C. Nawijn and A. J. van Oosterhout. Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures. J Immunol Methods Aug 31;371(1-2):114-21, 2011 Jahn-Schmid, B., W. F. Pickl and B. Bohle. Interaction of Allergens, Major Histocompatibility Complex Molecules, and T Cell Receptors: A 'Ménage à Trois' That Opens New Avenues for Therapeutic Intervention in Type I Allergy. Int Arch Allergy Immunol. 156(1):27-42, 2011 Toda, M., G. Reese, G. Gadermaier, V. Schulten, I. Lauer, M. Egger, P. Briza, S. Randow, S. Wolfheimer, V. Kigongo, M. Del Mar San Miguel Moncin, K. Fötisch, B. Bohle, S. Vieths and S. Scheurer. Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen. J Allergy Clin Immunol. May 13. [Epub ahead of print] PMID: 21571358 [PubMed - as supplied by publisher], 2011 Egger, M., A. Jürets, M. Wallner, P. Briza, S. Ruzek, S. Hainzl, U. Pichler, C. Kitzmüller, B. Bohle, C. G. Huber and F. Ferreira. Assessing Protein Immunogenicity with a Dendritic Cell Line-Derived Endolysosomal Degradome. PLoS One Feb 16;6(2):e17278, 2011 Cejka, D., A. Jäger-Lansky, H. Kieweg, M. Weber, C. Bieglmayer, D. G. Haider, D. Diarra, J. Patsch, F. Kainberger, B. Bohle and M. Haas. Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients. Nephrol Dial Transplant May 25. [Epub ahead of print] PMID: 21613383, 2011 Baranyi, U., M. Gattringer, A. Boehm, K. Marth, M. Focke-Tejkl, B. Bohle, K. Blatt, P. Valent, R. Valenta and T. Wekerle. Expression of a Major Plant Allergen as Membrane-Anchored and Secreted Protein in Human Cells with Preserved T Cell and B Cell Epitopes. Int Arch Allergy Immunol. 156:259-266 (DOI: 10.1159/000323733), 2011 Schulten, V., B. Nagl, E. Scala, M. L. Bernardi, A. Mari, M. A. Ciardiello, I. Lauer, S. Scheurer, P. Briza, A. Jürets, F. Ferreira, B. Jahn-Schmid, G. F. Fischer and B. Bohle. Pru p 3, the non-specific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy DOI 10.1111/j.1398-9995.2011.02567, 2011Geroldinger-Simic, M., T. Zelniker, W. Aberer, C. Ebner, C. Egger, A. Greiderer, N. Prem, J. Lidholm, B.K. Ballmer- Weber, S. Vieths, and B. Bohle. Birch pollen-related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol. DOI 10.1016/j.jaci.2010.10.027, 2011 Ilk, N., C. T. Schumi, B. Bohle, E. M. Egelseer and U. B. Sleytr. Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy. Microbial Cell Factories 10:6,2011, doi:10.1186/1475-2859-10-6, 2011 Varga, E. M., D. Kollmann, M. Zach and B. Bohle. Anaphylaxis to buckwheat in an atopic child: a risk factor for severe allergy to nuts and seeds?. Int Arch Allergy Immunol. 156(1):112-6, 2011 Wallner, M., M. Hauser, M. Himly , N. Zaborsky, S. Mutschlechner, A. Harrer, C. Asam, U. Pichler, R. van Ree, P. Briza, J. Thalhamer, B. Bohle, G. Achatz, and F. Ferreira. Reshaping the Bet v 1-fold modulates T-helper polarization. J Allergy Clin Immunol. Jun;127(6):1571-8.e9, 2011 Schmetterer, K., D. Haiderer, V.M. Leb-Reichl, A. Neunkirchner, B. Jahn-Schmid, H.J. Küng, K. Schuch, P. Steinberger, B. Bohle and W.F. Pickl. Bet v 1-specific TCR/Foxp3 transgenic T-cells suppress Bet v 1-specific T- cell effector function in an activation dependent manner. J Allergy Clin Immunol. 127:238, 2011
Jahn-Schmid, B., N. Wopfner, G. Hubinger, R. Asero, C. Ebner, F. Ferreira and B. Bohle. The T cell response to Amb a 1 is characterized by three dominant epitopes and multiple MHC-restriction elements. J Allergy Clin Immunol. 126:1068, 2010 Mutschlechner, S., M. Egger, P. Briza, M. Wallner, P. Lackner, A. Karle, A.B. Vogt, G.F. Fischer, B. Bohle* and F. Ferreira*. Naturally processed T cell-activating peptides of the major birch pollen allergen. J Allergy Clin Immunol. 125:711, 2010 * B.B. and F.F. are cosenior authors Gadermaier, G., B. Jahn-Schmid, L. Vogel, M. Egger, M. Himly, P. Briza, C. Ebner, S. Vieths, B. Bohle and F. Ferreira. Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy. Mol Immunol. 47:1292, 2010
Schulten, V., A. Radakovics,C. Hartz, A. Mari, S. Vazquez-Cortes, M. Fernandez-Rivas, I. Lauer, B. Jahn-Schmid, T Eiwegger, S. Scheurer and Bohle B. Characterization of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach. J Allergy Clin Immunol. 2009 Seppälä, U., D. Selby,R. Monsalve, TP. King, C. Ebner, P. Roepstorff and B. Bohle. Structural and immunological characterization of the N-glycans from the major yellow jacket allergen Ves v 2: the N-glycan structures are needed for the human antibody recognition. Mol Immunol. 46:2014-2, 2009 Gerstmayr, M., N. Ilk, B. Jahn-Schmid, U. B. Sleytr and B. Bohle. Natural self-assembly of allergen-S-layer fusion proteins is no prerequisite for reduced allergenicity and T cell stimulatory capacity. Int Arch Allergy Immunol. 149:231, 2009 Pree, I., J. Reisinger, B. Bohle, S. Frantal, R. Valenta and V. Niederberger. A sensitive assay for the detection of IgE bound to the major birch pollen allergen, Bet v 1, in the form of immune complexes. J Immunol Methods 345:100-105, 2009 Wopfner, N., B. Jahn-Schmid, G. Schmidt, T. Christ, G. Hubinger, P. Briza, C. Radauer, B. Bohle, L. Vogel, C. Ebner, R. Asero, F. Ferreira and R. Schwarzenbacher. The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level. Mol Immunol. 46:2090-7, 2009 Knapp, B., U. Omasits, B. Bohle, B. Maillere, C. Ebner, W. Schreiner and B. Jahn-Schmid. 3-Layer-based analysis of peptide-MHC interaction: in silico prediction, peptide binding affinity and T cell activation in a relevant allergen-specific model. Mol Immunol. 46:1839-44, 2009 Wallner, M., A. Erler, M. Hauser, E. Klinglmayr, G. Gadermaier, L. Vogel, A. Mari, B. Bohle, P. Briza, and F. Ferreira. Immunologic characterization of isoforms of Car b 1 and Que a 1, the major hornbeam and oak pollen allergens. Allergy 64:452, 2009 Leb, V.M ., B. Jahn-Schmid , H. J. Kueng , K.G. Schmetterer , D. Haiderer , A. Neunkirchner , G. F. Fischer , K. Nissler , A. Hartl , J. Thalhamer , P. Steinberger, B. Bohle , B. Seed and W. F. Pickl . Modulation of allergen-specific T-lymphocyte function by virus- like particles decorated with HLA Class II molecules. J Allergy Clin Immunol. 2009, in press
Jahn-Schmid, B., P. Sirven, V. Leb, W. F. Pickl, G. F. Fischer, G. Gadermaier, M. Egger, C. Ebner F. Ferreira, B. Maillére and B. Bohle. Characterization of HLA-class II / peptide-TCR interactions of the immunodominant T cell Epitope in Art v 1, the major mugwort pollen allergen. J Immunol. 181:3636, 2008 Eiwegger, T., E. Mayer, S. Brix, I. Schabussova, E. Dehlink, B. Bohle, V. Barkholt, and Z. Szépfalusi. Allergen specific responses in cord and adult blood are differentially modulated in the presence of endotoxins. Clin Exp Allergy 2008, in press Van Overtvelt, L., E. Wambre, B. Maillère, E. von Hofe, A. Louise, A.M. Balazuc, B. Bohle, D. Ebo, C. Leboulaire, G. Garcia, and P. Moingeon. Assessment of Bet v 1-Specific CD4+ T Cell Responses in Allergic and Nonallergic Individuals Using MHC Class II Peptide Tetramers. J Immunol. 180:4514-22, 2008 Mittermann, I., R. Reininger, M. Zimmermann, K. Gangl, J. Reisinger, K.J. AichbergerJ, E.K. Greisenegger, V. Niederberger, J. Seipelt, B. Bohle, T. Kopp, C.A. Akdis, S. Spitzauer, P. Valent, and R. Valenta. The IgE-Reactive Autoantigen Hom s 2 Induces Damage of Respiratory Epithelial Cells and Keratinocytes via Induction of IFN-gamma. J Invest Dermatol. 128:1451, 2008 Leb, V.M., B. Jahn-Schmid, K.G. Schmetterer, H. J. Kueng, D. Haiderer, A. Neunkirchner, G. F. Fischer, K. Nissler, A. Hartl, J. Thalhamer, B. Bohle, B. Seed, W. F. Pickl. Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes. J Allergy Clin Immunol. 121:64-71, 2008
Gerstmayr, M., N. Ilk, I. Schabussova, B. Jahn-Schmid, E.M. Egelseer, U.B. Sleytr, C. Ebner and B. Bohle. A Novel Approach to Specific Allergy Treatment: The Recombinant Allergen-S-Layer Fusion Protein rSbsC-Bet v 1 Matures Dendritic Cells that Prime Th0/Th1 and IL-10-Producing Regulatory T Cells. J Immunol. 179:7270, 2007 Bohle, B., Kinaciyan, T., M. Gerstmayr, A. Radakovics, B. Jahn-Schmid, and C. Ebner. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T cell tolerance and immune deviation. J Allergy Clin Immunol. 120:707, 2007 Kinaciyan, T., B. Jahn-Schmid, A. Radakovics, B. Zwölfer, C. Schreiber, J.N. Francis, C. Ebner and B. Bohle. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1-homolog Mal d 1. J Allergy Clin Immunol. 119:937, 2007 Admyre, Ch., B. Bohle, S.M. Johansson, M. Focke-Tejkl, R. Valenta, A. Scheynius, and S. Gabrielsson. B-cell-derived exosomes can present allergen peptides and activate allergen-specific T-cells to proliferate and produce Th2-like cytokines. J Allergy Clin Immunol. 120:1418, 2007 59. Wallner, M., A. Stöckliner, T. Thalhamer, B. Bohle, L. Vogel, P. Briza, H. Breiteneder, S. Vieths, A. Hartl, A. Mari, C. Ebner, P. Lackner, P. Hammerl, J. Thalhamer, and F. Ferreira. Allergy multi-vaccines created by DNA shuffling of tree pollen allergens. J Allergy Clin Immunol. 120:374, 2007
Bohle, B., B. Zwölfer, A. Heratizadeh, B. Jahn-Schmid, Y. Dall Antonia, M. Alter, W. Keller, L. Zuidmeer, R. van Ree, T. Werfel and C. Ebner. Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol. 118:242, 2006 Fuchs, H.C, B. Bohle, Y Dall'Antonia, C. Radauer, K. Hoffmann-Sommergruber, A. Mari, O. Scheiner, W. Keller and H. Breiteneder. Natural and recombinant molecules of the cherry allergen Pru av 2 show diverse structural and B cell characteristics but similar T cell reactivity. Clin Exp Allergy 36:359, 2006 Ma,Y., L. Zuidmeer, L., B. Bohle, S.T. Bolhaar, G. Gadermaier, E. Gonzalez-Mancebo, M. Ferdandez-Rivas, A.C. Knulst, M. Himly, R. Asero, C. Ebner, R. van Ree, F. Ferreira, H. Breiteneder and K. Hoffmann-Sommergruber. Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. Clin Exp Allergy 36:1087, 2006 Ma,Y., G. Gadermaier, B. Bohle, S. Bolhaar, A. Knulst, Z. Markovic-Housley, H. Breiteneder, P. Briza, K. Hoffmann-Sommergruber and F. Ferreira. Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. Int Arch Allergy Immunol. 139:53, 2006 Fernandez-Rivas, M., S. Bolhaar, E. Gonzlez-Mancebo, R. Asero, A. van Leeuwen, B. Bohle, Y. Ma, C. Ebner, N. Rigby, A.I. Sancho, S. Miles, L. Zuidmeer, A. Knulst, H. Breiteneder, C. Mills, K. Hoffmann-Sommergruber and R. van Ree. Apple allergy across Europe: How allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol. 118:481, 2006 Dehlink, E., T. Eiwegger, M. Gerstmayr, E. Kampl, B. Bohle, K.W. Chen, S. Vrtala, R. Urbanek, and Z. Szépfalusi. Absence of systemic immunologic changes during dose-build-up phase and early maintenance period in effective specific sublingual immunotherapy in children. Clin Exp Allergy 36:32, 2006
Schimek, E.M., B. Zwölfer, P. Briza, B. Jahn-Schmid, L. Vogel, S. Vieths, C. Ebner and B. Bohle. Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator-releasing but not T cell-activating capacity. J Allergy Clin Immunol. 116:1327, 2005 Jahn-Schmid, B., A. Radakovics, D. Lüttkopf, S. Scheurer, S. Vieths, C. Ebner and B. Bohle. Bet v 1142-156 is the dominant T cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens. J Allergy Clin Immunol. 116:213, 2005 Bohle, B., A. Radakovics, D. Lüttkopf, S. Vieths and C. Ebner. Characterisation of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens. Clin Exp Allergy 35:1392, 2005 Bohle, B., B. Zwölfer, G.F. Fischer, U. Seppälä, T. Kinaciyan, C. Bolwig, M.D. Spangfort and C. Ebner. Characterisation of the human T cell response to Antigen 5 from Vespula Vulgaris (Ves v 5). Clin Exp Allergy 35:367, 2005 Konakci, K.Z., B. Bohle+, R. Blumer, W. Hoetzenecker, G. Roth, B. Moser, G. Boltz-Nitulescu, M. Gorlitzer, W. Klepetko, E. Wolner and H.J. Ankersmit. Alpha-Gal on Bioprostheses: Xenograft Immune Response In Cardiac Surgery. J Eur Clin Invest. 35:17, 2005. +both authors contributed equally Roth-Walter, F., B. Bohle, I. Schoell, E. Untersmayr, O. Scheiner, G. Boltz-Nitzlescu, F. Gabor, D. Brayden, and E. Jensen-Jarolim. Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles. Immunol Lett. 100:182, 2005 Jahn-Schmid, B., GF. Fischer, B. Bohle, I. Faé, G. Gadermaier, A. Dedic, F. Ferreira and C. Ebner. Antigen-presentation of the immunodominant T cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1*01. J Allergy Clin Immunol. 115:399, 2005 Ballmer-Weber, B.K., A. Wangorsch, B. Bohle, S. Kaul, T. Kündig, K. Fötisch, R. van Ree, and S. Vieths. Component-resolved in vitro diagnosis in carrot allergy: Does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure? Clin Exp Allergy 35:970, 2005 Reisinger J., A. Triendl, Kuchler E, B. Bohle, MT. Krauth, I. Rauter, P. Valent, F. Koenig, R. Valenta, and V. Niederberger. IFN-gamma-enhanced allergen penetration across respiratory epithelium augments allergic inflammation. J Allergy Clin Immunol. 115:937, 2005 Aichberger, K.J., I. Mittermann, I., R. Reininger, R., S. Seiberler, I. Swoboda, S. Spitzauer, T. Kopp, G. Stingl, W. R. Sperr, P. Valent, A. Repa, B. Bohle, D. Kraft and R. Valenta. Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins can induce T helper cell type 1-mediated autoractivity. J Immunol. 175:1286, 2005 Batard, T., A. Didierlaurent, H. Chabre, N. Mothes, L. Bussieres, B. Bohle, M.N. Couret, T. Ball, P. Lemoine, M. Focke-Teijkl, A. Chenal, G. Clement, F. Dupont, P. Valent, M.T. Krauth, C. Andre, R. Valenta and Moingeon, P. Characterization of Wild-Type Recombinant Bet v 1a as a Candidate Vaccine against Birch Pollen Allergy. Int Arch Allergy Immunol. 136:239, 2005
Bohle, B., A. Breitwieser, B. Zwölfer, B. Jahn-Schmid, M. Sára, U. B. Sleytr and C. Ebner. A Novel Approach to Specific Allergy Treatment: The recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v1) combines reduced allergenicity with immunomodulating capacity. J Immunol. 172:6642, 2004 Novak, N., R. Valenta, B. Bohle, S. Laffer, J. Haberstok, S. Kraft, and T. Bieber. FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro. J Allergy Clin Immunol. 113:949, 2004 Repa, A., C. Wild, K. Hufnagl, B. Winkler, B. Bohle, A. Pollak and U. Wiedermann. Influence of the route of sensitization on local and systemic immune responses in a murine model of type I allergy. Clin Exp Immunol. 137:12, 2004 Wagner, M., H. Poeck, B. Jahrsdoerfer, S. Rothenfusser, D. Prell, B. Bohle, E. Tuma, T. Giese, J. W. Ellwart, S. Endres, and G. Hartmann. IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA. J Immunol. 172:954, 2004
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