Clinical Pharmacokinetics /Pharmacogenetics and Imaging
   

Markus Zeitlinger, M.D.
Section Head

[ Curriculum Vitae ]

Mission Statement

Our mission is to perform clinical studies in healthy volunteers and patients to elucidate the impact of genetic variants and various pathophysiological states on pharmacokinetics and pharmacodynamics.

Our main focus is the study of the drug distribution process by employing techniques to measure target site distribution directly, i.e. PET or microdialysis.  

 

 

BBB penetration of a 11C-labeled anti-amyloid drug in a healthy volunteers and Alzheimers patient


Detection of genes with differential response patterns during endotoxemia with different response patterns after treatment with the statin drugs

Current Projects

  • PK-PD correlations of anti-infectives

  • Transporter imaging at the level of the blood brain barrier by small animal PET (µ-PET) and clinical PET in patients

  • Alzheimer plaque imaging 

  • Clinical studies on genoptype / phenoptype correlations

  • Expression profiling studies on drug effects in healthy volunteers


Key Publications:

Schmidt WM, Spiel AO, Jilma B, Wolzt M and Mueller M. In Vivo Effects of Simvastatin and Rosuvastatin on Global Gene Expression in Peripheral Blood Leukocytes in a Human Inflammation Modell. Pharmacogenet Genom 18(2):109-120 (2008)    

Wagner CC,   M Müller, G Lappin and O Langer. Positron emission tomography for use in microdosing studies.   Curr Opin Drug Discov Devel.11(1):104-10 (2008)    

Langer O, Bauer M, Hammers A, Karch R, Pataraia E, Koepp MJ, Abrahim AA, Luurtsema G, Brunner M, Sunder-Plassmann R, Zimprich F, Joukhadar C, Gentzsch S, Dudczak R, Kletter K, Baumgartner C and Müller M. Pharmacoresistance in Epilepsy: A Pilot PET Study with the P-Glycoprotein Substrate R-[C]verapamil. Epilepsia 2007, 48(9): 1774-1784                               

Bauer M, Langer O, Dal Bianco P, Karch R, Brunner M, Abrahim A, Lanzenberger R, Hofmann A, Joukhadar C, Carminati P, Ghirardi O, Piovesan P, Forloni G, Corrado M, Lods N,  Dudczak R, Auff E, Kletter K and Müller M. A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer´s disease. Clin Pharmacol Ther 80(3):216-227 (2006)

Brunner M, Langer O, Sunder-Plassmann R, Dobrozemsky G, Müller U, Wadsak W, Krcal A, Mannhalter C, Dudczak R, Kletter K, Steiner I, Baumgartner C and Müller M. Influence of functional haplotypes in the drug transporter gene ABCB1 on CNS drug distribution in humans. Clin Pharmacol Ther 78: 182-190 (2005)

Sauermann R, Delle-Karth G, Marsik C, Steiner I, Zeitlinger M, Mayer B, Georgopulos A, Müller M, and Joukhadar C. Pharmacokinetics and pharmacodynamics of cefpirome in subcutaneous adipose tissue of septic patients. Antimicrob Agents Chemother49: 650-655 (2005)

Zeitlinger M, Sauermann R, Traunmüller F, Georgopoulos A, Müller M, Joukhadar C. The impact of plasma protein binding on antimicrobial activity by use of time-killing curves. Epub 2004 Oct 7. J Antimicrob Chemother 54(5):876-80 (2004)

Müller M, A.delaPena and H. Derendorf. Issues in PK-PD of antibiotics: Tissue penetration. Antimicrobial Agents Chemother 48(5):1441-1453 (2004)