beyond the usual phase I-IV capabilities:
A wide array of special innovative techniques.
|
Cardiovascular Clinical Medicine |
|
| Clinical Parameter | Method applied Systemic hemodynamics |
| Cardiac performance (Cardiac output, systolic function) |
Impedance cardiography Echocardiography Systolic time intervals |
| Cardiac electrophysiology | Signal averaging ECG Holter ECG RR-Variability |
| Systemic blood pressure | Systemic blood pressure (Non-) invasive measurement 48 h ambulant blood pressure Pulse oxymetry |
| Skin and muscle blood flow | Laser Doppler flowmeter |
| Renal blood flow (RBF) Renal sodium excretion Glomerular filtration rate (GFR) Hepatic blood flow Forearm blood flow |
PAH-Clearance Lithium-Clearance Inulin-Clearance ICG-Clearance, Ultrasound doppler Plethysmography |
| Venous responsiveness | Hand vein compliance technique Photoplethysmography |
| Conduit & resistence vessel blood flow |
Forearm plethysmography High-resolution ultrasound brachial artery |
| Analyses: Endogenous nitric oxide inhibitors (ADMA, SDMA), andrenochrome metabolites | HPLC |
| Clinical Pharmacokinetics
/ Pharmacogenetics and Imaging |
|
| Clinical Parameter | |
| Phase I-IV studies | |
| Interstitial drug concentrations
in skeletal muscle, subcutaneous adipose tissue, skin, solid tumors, brain. lung |
Microdialysis |
| Transdermal bioequivalence | Microdialysis combined 2 D ultrasound Repeat skin biopsies Skin blister techniques |
| Gamma Scintigraphy:
Gastrointestinal transit time |
Activated samarium labeling, Tc99 labeling |
| Mass balance studies | Administration of 14C labeled compounds |
| Tissue drug concentrations | Magnetic Resonance Spectroscopy
Positron Emission Tomography (PET) Micro PET |
| Preclinical studies | |
| Cell culture studies | |
| Ophthalmo-Pharmacology |
|
| Clinical Parameter | Method applied |
| Retinal blood flow | Laser Doppler velocimetry |
| Choroidal and optic disk blood flow | Laser Doppler flowmetry |
| Optic disk and retinal blood flow | Scanning laser Doppler flowmetry (HRF) |
| Pulsatile ocular blood flow | Laser interferometric measurements of fundus pulsations |
| Pulsatile ocular blood flow | Pneumotonometry |
| Retinal blood flow | Blue field and entoptic techniques |
| Flow velocities in extraocular vessels | Color Doppler imaging |
| Immunology & Hematology | |
| Clinical Parameter | Method applied Extracorporal circulation |
| Anti-adhesive and anti-coagulant strategies in systemic inflammation | Endotoxemia in man (iv. infusion of Reference Standard E. Coli endotoxin) Flow-cytometric analysis TiFACT-Sonoclot ELISA |
| Selective depletion of blood cells Biocompatibility testing Systemic inflammation and leukocyte emmigration |
Platelet-, Leucopheresis Hemodialysis Cardiopulmonary bypass in patients undergoing cardiac surgery |
| Method applied Platelets and coagulation |
|
| In vivo testing of anticoagulant drugs Thrombopoiesis and platelet turnover Platelet function Platelet receptor polymorphism Platelet receptor density Platelet function |
Shed blood technique Thrombelastography Reticulated platelet counts, thrombopoietin levels and glycocalicin Ex-vivo platelet aggregometry Genotyping by polymerase chain reaction Phenotyping by flow cytometry Platelet function analyzer PFA-100 Simplate bleeding time Biotinylation |
| Biopharmaceutical and Chemical Analyses | |
| Development of new analytical methods and their application to samples from university and industry | |
| Determination of antibiotics (Levofloxacin, Ciprofloxacin, Piperacillin, Cefazolin, Cefuroxime, Cefpirome, Fosfomycin) in plasma and tissue dialysates | |
| Determination of modified amino acids (L-NMMA, Dimethylarginines) in plasma | |
| Preparation of fused-silica capillary columns coated with low-bleed stationary phases for gas chromatography | |