The Gert Lubec Proteomics Laboratory

at the Medical University of Vienna

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The Gert Lubec Proteomics Laboratory

We are running a proteomics unit (see lab ranking at http://www.proteomicsresearch.org/labs.php) that is focussing on the one hand on functional neuroproteomics, evolution biology of a toxic protein and on the other hand, spontaneous ideas are followed in all areas of chemistry, biology and medicine, many projects are carried out as cooperations with scientists from all over the world.

Flexibility, warranted by our sponsor enables most efficient planning, creative and spontaneous concepts.

One major focus of the laboratory is represented by research on proteins involved in learning, memory formation and thinking in rodents. Using a series of paradigms for spatial, olfactory, working and contextual memory, we try to link protein levels, protein complexes, splice variants and posttranslational modifications to the parameters obtained from behavioural paradigms. These tests are carried out in rats and several mouse strains, both, wild caught and laboratory mouse strains because of enormous strain/dependent differences in learning and memory (L&M). Gel based mass spectrometry approaches are used in the majority of protein determinations and form the basis for the abovementioned studies. Based upon the experience of this lab on the identification and characterisation of receptor proteins from brain tissue, these structures are holding centre stage in the laboratory. In addition to the abovementioned investigations peptides linked to behaviour are performed as well and cognitive enhancers are being tested with extraordinarily important outcome. Moreover, we search for mechanisms of cognitive enhancement in functional neuroproteomics studies in terms of showing involvement of protein pathways and cascades. Neuroproteomic studies are complemented by verifying results using electrophysiological techniques and by immunohistochemical techniques cells and subareas involved are identified. Finally, results are verified in genetically manipulated mice or in cell culture. Proteomic techniques developed in our laboratory provide the basis for research on brain receptors, in particular brain receptor complexes. 

The currently most intriguing finding is that of cognitive enhancers in the rat that improve working memory up to 30% and evidence for the action mechanisms is provided and indeed, receptor complexes and transporter systems involved are identified. In cooperation with our research partners worldwide we are now about  to bring our molecular therapeutics through preclinical studies to the clinic and extend the repertoire of the abovementioned cognitive enhancers. 


Univ.Prof.Dr. Gert Lubec, FRSC (UK)

 

Here is a list of top 10 scientists working in the field of Proteomics research.

1. Prof. Dr. Matthias Mann, Max Planck Institute for Biochemistry, Martinstied (near Munich), Germany

2. Prof. Ruedi Aebersold, Institute for Molecular Systems Biology, ETH Zurich, Switzerland

3. Prof. Dr.John R. Yates III, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd. SR11, La Jolla, California 92037

4. Prof. Dr. Richard D. Smith, Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Washington 99352, USA

5. Prof. Dr. Julio (J.E.) Celis, Danish Cancer Society Research Center, Copenhagen, Denmark DK-2100

6. oUniv. Prof. Dr. Gert Lubec, The Gert Lubec Proteomics Laboratory, Medical University of Vienna, Dept. of Pediatrics, Vienna, Austria

7. Prof. Dr. Albert J. R. Heck, Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University, The Netherlands

8. Prof. Dr. Lance A. Liotta, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA

9. Prof. Dr. Emanuel Petricoin III, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA

10. Prof. Dr. Fuchu He, Beijing Proteome Research Center, Beijing 100850, P. R. China