Robert Eferl, PhD
Institute for Cancer Research (ICR),
Our laboratory is investigating signaling pathways implicated in cancer formation. We focus on Ras and Jak/Stat signaling and study the importance of these pathways in tumor cells and cells of the tumor microenvironment. For that purpose we have established novel mouse tumor models and employ conditional gene inactivation approaches to identify Ras and Jak/Stat functions during tumor initiation and tumor progression. In particular, we are interested in Stat1 and Stat3 functions in liver and colorectal cancer. Activation of Stats is mediated by cytokines. Therefore, these transcription factors are considered as promising candidates that could provide a molecular link between inflammation and cancer development.
Pathria, P., D. Gotthardt, M. Prchal-Murphy, EM. Putz, M. Holcmann, M. Schlederer, B. Grabner, I. Crncec, J. Svinka, M. Musteanu, T. Hoffmann, M. Filipits, W. Berger, V. Poli, L. Kenner, M. Bilban, E. Casanova, M. Müller, B. Strobl, E. Bayer, T. Mohr, V. Sexl and R. Eferl. 2015. Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. OncoImmunology 4(4):e998529. eCollection 2015.
Musteanu, M., L. Blaas, R. Zenz, J. Svinka, T. Hoffmann, B. Grabner, D. Schramek, H.P. Kantner, M. Müller, T. Kolbe, T. Rülicke, R. Moriggl, L. Kenner, D. Stoiber, J.M. Penninger, H. Popper, E. Casanova, and R. Eferl. 2012. A mouse model to identify cooperating signaling pathways in cancer. Nat Methods 9: 897-900.