Veronika Sexl, MD

Insitute of Pharmacology and Toxicology
University of Veterinary Medicine Vienna
Veterinärplatz 1
A-1210 Vienna, Austria
Tel: +43-1-25077-4422
Fax:
Email: veronika.sexl@vetmeduni.ac.at
Website: http://www.jak-stat.at

Research interests

The focus of the lab is to study signaling involved in leukemogenesis and NK cell-mediated tumor surveillance. Previous studies taught us that Bcr/Abl induced leukemia is exclusively subject to NK cell mediated tumor surveillance. We also identified the transcription factor Stat1 as key regulator for NK cell mediated leukemia surveillance.


Selected publications

Hölbl A, Schuster C, Kovacic B, Zhu B, Wickre M, Hoelzl M, Fajmann S, Grebien F, Warsch W, Stengl G, Hennighausen L, Poli V, Beug H, Moriggl R, Sexl V. Stat5 is indispensable for the maintenance of bcr/abl positive leukaemia (2010). EMBO Mol Med, 2(3):98-110. 

Zebedin E, Simma O, Schuster C, Putz EM, Fajmann S, Warsch W, Eckelhart E, Stoiber D, Weisz E, Schmid JA, Pickl WF, Baumgartner C, Valent P, Piekorz RP, Freissmuth M, Sexl V. Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance (2008). Blood 112:4655-64.

Hölbl A, Kovacic B, Kerenyi MA, Simma O, Warsch W, Cui Y, Beug H, Hennighausen L, Moriggl R, Sexl V. Clarifying the role of Stat5 in lymphoid development and Abelson induced transformation (2006). Blood 107:4898-906.
 

Kovacic B, Stoiber D, Moriggl R, Weisz E, Ott RG, Kreibich R, Levy DE, Beug H, Freissmuth M, Sexl V. STAT1 acts as a tumor promoter for leukaemia development (2006). Cancer Cell 10:77-87.