PhD-Program Inflammation and Immunity
Medizinische Universität Wien

Recent publicatons of IAI students

 

2019

Klufa J, Bauer T, Hanson B, Herbold C, Starkl P, Lichtenberger B, Srutkova D, Schulz D, Vujic I, Mohr T, Rappersberger K, Bodenmiller B, Kozakova H, Knapp S, Loy A, Sibilia M. Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy. Sci Transl Med. 2019 Dec 11;11(522). pii: eaax2693. doi: 10.1126/scitranslmed.aax2693.

Klein K, Witalisz-Siepracka A, Maurer B, Prinz D, Heller G, Leidenfrost N, Prchal-Murphy M, Suske T, Moriggl R, Sexl V. STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia. Leukemia. 2019 Sep;33(9):2336-2340. doi: 10.1038/s41375-019-0471-3. Epub 2019 Apr 9.

Amberg N, Sotiropoulou PA, Heller G, Lichtenberger BM, Holcmann M, Camurdanoglu B, Baykuscheva-Gentscheva T, Blanpain C, Sibilia M. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner. iScience. 2019 May 31;15:243-256. doi: 10.1016/j.isci.2019.04.018. Epub 2019 Apr 17.

Gawish R, Bulat T, Biaggio M, Lassnig C, Bago-Horvath Z, Macho-Maschler S, Poelzl A, Simonović N, Prchal-Murphy M, Rom R, Amenitsch L, Ferrarese L, Kornhoff J, Lederer T, Svinka J, Eferl R, Bosmann M, Kalinke U, Stoiber D, Sexl V, Krmpotić A, Jonjić S, Müller M, Strobl B. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Rep. 2019 Feb 26;26(9):2394-2406.e5

 

 

2018

Linder M, Glitzner E, Srivatsa S, Bakiri L, Matsuoka K, Shahrouzi P, Dumanic M, Novoszel P, Mohr T, Langer O, Wanek T, Mitterhauser M, Wagner EF, Sibilia M. EGFR is required for FOS-dependent bone tumor development via RSK2/CREB signaling. EMBO Mol Med. 2018 Nov;10(11). pii: e9408. doi: 10.15252/emmm.201809408.

Linder M, Hecking M, Glitzner E, Zwerina K, Holcmann M, Bakiri L, Ruocco MG, Tuckermann J, Schett G, Wagner EF, Sibilia M. EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation. Cell Death Differ. 2018 Jun;25(6):1094-1106. doi: 10.1038/s41418-017-0054-7. Epub 2018 Feb 14.

Crncec I, Modak M, Gordziel C, Svinka J, Scharf I, Moritsch S, Pathria P, Schlederer M, Kenner L, Timelthaler G, Müller M, Strobl B, Casanova E, Bayer E, Mohr T, Stöckl J, Friedrich K, Eferl R. STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer. Mol Oncol. 2018 Apr;12(4):514-528. doi: 10.1002/1878-0261.12178. Epub 2018 Feb 20.

Parrini M, Meissl K, Ola MJ, Lederer T, Puga A, Wienerroither S, Kovarik P, Decker T, Müller M, Strobl B. The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment. Front Immunol. 2018 Dec 6;9:2879. doi: 10.3389/fimmu.2018.02879. eCollection 2018.

 

2017

Zulehner N, Nagl B, Briza P, Roulias A, Ballmer-Weber B, Zlabinger GJ, Ferreira F, Bohle B. Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot. Allergy. 2017 Feb;72(2):244-251. doi: 10.1111/all.12938. Epub 2016 Jun 10.

Müller L, Hainberger D, Stolz V, Hamminger P, Hassan H, Preglej T, Boucheron N, Sakaguchi S, Wiegers GJ, Villunger A, Auwerx J, Ellmeier W. The corepressor NCOR1 regulates the survival of single-positive thymocytes. Sci Rep. 2017 Nov 21;7(1):15928. doi: 10.1038/s41598-017-15918-0.

Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M. EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients. Gastroenterology. 2017 Jul;153(1):178-190.e10. doi: 10.1053/j.gastro.2017.03.053.

Granofszky N, Farkas AM, Muckenhuber M, Mahr B, Unger L, Maschke S, Pilat N, Holly R, Wiletel M, Regele H, Wekerle T. Anti-Interleukin-6 Promotes Allogeneic Bone Marrow Engraftment and Prolonged Graft Survival in an Irradiation-Free Murine Transplant Model. Front Immunol. 2017 Jul 19;8:821. doi: 10.3389/fimmu.2017.00821. eCollection 2017

Edlinger L, Berger-Becvar A, Menzl I, Hoermann G, Greiner G, Grundschober E, Bago-Horvath Z, Al-Zoughbi W, Hoefler G, Brostjan C, Gille L, Moriggl R, Spittler A, Sexl V, Hoelbl-Kovacic A. Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1. Br J Haematol. 2017 Jul 14. doi: 10.1111/bjh.14833

Puck A, Hopf S, Modak M, Majdic O, Cejka P, Blüml S, Schmetterer K, Arnold-Schrauf C, Gerwien JG, Frederiksen KS, Thell E, Leitner J, Steinberger P, Aigner R, Seyerl-Jiresch M, Zlabinger GJ, Stöckl J. The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state. Eur J Immunol. 2017 Jan;47(1):193-205. doi: 10.1002/eji.201646405.

Amberg N, Holcmann M, Stulnig G, Glitzner E, Sibilia M. Effects of Depilation Methods on Imiquimod-Induced Skin Inflammation in Mice. J Invest Dermatol. 2017 Feb;137(2):528-531. doi: 10.1016/j.jid.2016.09.018.

 

2016

Amberg N, Holcmann M, Stulnig G, Sibilia M. Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression. J Invest Dermatol. 2016 Nov;136(11):2140-2149. doi: 10.1016/j.jid.2016.06.613.

Amberg N, Holcmann M, Glitzner E, Novoszel P, Stulnig G, and Sibilia M. 2015. Mouse models of nonmelanoma skin cancer. Methods Mol Biol.1267:217-50.

Komposch, K., and M. Sibilia. 2016. EGFR Signaling in Liver Diseases. International journal of molecular sciences 17.

Zulehner N, Nagl B, Briza P, Roulias A, Ballmer-Weber B, Zlabinger GJ, Ferreira F, Bohle B. Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot. Allergy. 2017 Feb;72(2):244-251. doi: 10.1111/all.12938. Epub 2016 Jun 10

Zhu C, Fuchs CD, Halilbasic E, Trauner M. Bile acids in regulation of inflammation and immunity: friend or foe? Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):25-31. Epub 2016 Jul 29. Review

Modak M, Majdic O, Cejka P, Jutz S, Puck A, Gerwien JG, Steinberger P, Zlabinger GJ, Strobl H, Stöckl J. Engagement of distinct epitopes on CD43 induces different co-stimulatory pathways in human T cells. Immunology. 2016 Nov;149(3):280-296. doi: 10.1111/imm.12642. Epub 2016 Aug 16.

 

2015

Amberg N, Holcmann M, Glitzner E, Novoszel P, Stulnig G, and Sibilia M. 2015. Mouse models of nonmelanoma skin cancer. Methods Mol Biol.1267:217-50. doi: 10.1007/978-1-4939-2297-0_10.

Subbarayal B, Schiller D, Möbs C, Pfützner W, Jahn-Schmid B, Gepp B, Breiteneder H, Vieths S, and Bohle B. 2015. The diversity of Bet v 1-specific IgG4 antibodies remains mostly constant during the course of birch pollen immunotherapy. J Allergy Clin Immunol. Jul 1. pii: S0091-6749(15)00731-9. doi: 10.1016/j.jaci.2015.05.025.

Crncec I, Pathria P, Svinka J, and Eferl R. 2015. Induction of colorectal cancer in mice and histomorphometric evaluation of tumors. Methods Mol Biol. 1267:145-64. doi: 10.1007/978-1-4939-2297-0_7.

Srinivasan B, Focke-Tejkl M, Weber M, Pahr S, Baar A, Atreya R, Neurath MF, Vogelsang H, Huber WD, and Valenta R. 2015. Usefulness of recombinant gamma-gliadin 1 for identifying patients with celiac disease and monitoring adherence to a gluten-free diet.  J Allergy Clin Immunol. Jun 13. pii: S0091-6749(15)00647-8. doi: 10.1016/j.jaci.2015.04.04

Wollmann E, Lupinek C, Kundi M, Selb R, Niederberger V, and Valenta R. 2015. Reduction in allergen-specific IgE binding as measured by microarray: A possible surrogate marker for effects of specific immunotherapy. J Allergy Clin Immunol. Sep; 136(3):806-809.e7. doi: 10.1016/j.jaci.2015.02.034.

Hock K, Mahr B, Schwarz C, and Wekerle T, 2015. Deletional and regulatory mechanismscoalesce to drive transplantation tolerance through mixed chimerism. Eur J Immunol. Sep; 45(9):2470-9. doi: 10.1002/eji.201545494.

Puck A, Aigner R, Modak M, Cejka P, Blaas D, Stöckl J. Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells. Results Immunol. 2015 Oct 22;5:23-32. doi: 10.1016/j.rinim.2015.10.001. eCollection 2015.

 

2014

Boucheron N*., Tschismarov R*., Göschl L., Moser MA, Lagger S., Sakaguchi S., Winter M., Lenz F., Vitko D., Breitwieser FP., Müller L., Hassan H., Bennett KL., Colinge J., Schreiner W., Egawa T., Taniuchi I., Matthias P., Seiser C., Ellmeier W. CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol. 2014 May;15(5):439-48. doi: 10.1038/ni.2864.*equal contribution.

Tschismarov R, Firner S, Gil-Cruz C, Göschl L, Boucheron N, Steiner G, Matthias P, Seiser C, Ludewig B, and Ellmeier W. 2014. HDAC1 controls CD8+ T cell homeostasis and antiviral response. PLoS One. Oct 21; 9(10):e110576. doi: 10.1371/journal.pone.0110576.

Glitzner, E., A. Korosec, P. M. Brunner, B. Drobits, N. Amberg, H. B. Schonthaler, T. Kopp, E. F. Wagner, G. Stingl, M. Holcmann, and M. Sibilia. 2014. Specific roles for dendritic cell subsets during initiation and progression of psoriasis. EMBO molecular medicine 6: 1312-1327.

Hock, K., N. Pilat, U. Baranyi, B. Mahr, M. Gattringer, C. Klaus, and T. Wekerle. 2014. Donor CD4 T cells trigger costimulation blockade-resistant donor bone marrow rejection through bystander activation requiring IL-6. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14: 2011-2022.

Lanaya*, H., A. Nataraja*, K. Komposch*, L. Li, N. Amberg, L. Chen, S. K. Wculek, M. Hammer, R. Zenz, M. Peck-Radosavljevic, W. Sieghart, M. Trauner, H. Wang, and M. Sibilia. 2014. EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nature cell biology 16: 972-981. *equal contribution.

Schwaiger, J., J. H. Aberle, K. Stiasny, B. Knapp, W. Schreiner, I. Fae, G. Fischer, O. Scheinost, V. Chmelik, and F. X. Heinz. 2014. Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction. Journal of virology 88: 7828-7842.

Zhou, J., F. Koszik, P. Brunner, and G. Stingl. 2014. "Overrepresentation of T17 cells in the peripheral blood of psoriatic patients is not confined to the skin-homing T cell subset". Journal of dermatological science 75: 190-193.)

 

2013

Subbarayal B, Schiller D, Möbs C, de Jong NW, Ebner C, Reider N, Bartel D, Lidholm J, Pfützner W, Gerth van Wijk R, Vieths S, Bohle B. Kinetics, cross-reactivity, and specificity of Bet v 1-specific IgG4 antibodies induced by immunotherapy with birch pollen. Allergy. 2013 Nov;68(11):1377-86. doi: 10.1111/all.12236.

Abramova A, Sakaguchi S, Schebesta A, Hassan H, Boucheron N, Valent P, Roers A, Ellmeier W. The Transcription Factor MAZR Preferentially Acts as a Transcriptional Repressor in Mast Cells and Plays a Minor Role in the Regulation of Effector Functions in Response to FcεRI Stimulation. PLoS One. 2013 Oct 17;8(10):e77677. doi: 10.1371/journal.pone.0077677.

Vratskikh O, Stiasny K, Zlatkovic J, Tsouchnikas G, Jarmer J, Karrer U, Roggendorf M, Roggendorf H, Allwinn R, Heinz FX. Dissection of antibody specificities induced by yellow fever vaccination. PLoS Pathog. 2013;9(6):e1003458. doi: 10.1371/journal.ppat.1003458.

Srinivasan B, Focke-Tejkl M, Swoboda I, Constantin C, Mittermann I, Pahr S, Vogelsang H, Huber WD, Valenta R. A combined biochemical, biophysical and immunological approach towards the identification of celiac disease-specific wheat antigens. Amino Acids. 2013 Oct;45(4):889-900. doi: 10.1007/s00726-013-1537-6.

Koprulu, A. D., R. Kastner, S. Wienerroither, C. Lassnig, E. M. Putz, O. Majer, B. Reutterer, V. Sexl, K. Kuchler, M. Muller, T. Decker, and W. Ellmeier. 2013. The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. PloS one 8: e60476.

Ramsey, H., N. Pilat, K. Hock, C. Klaus, L. Unger, C. Schwarz, U. Baranyi, M. Gattringer, E. Schwaiger, F. Wrba, and T. Wekerle. 2013. Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients. Transplant international : official journal of the European Society for Organ Transplantation 26: 206-218.

Hock K, Oberhuber R, Lee YL, Wrba F, Wekerle T, Tullius SG. Immunosenescence does not abrogate engraftment of murine allogeneic bone marrow. Transplantation. 2013 Jun 27;95(12):1431-8. doi: 10.1097/TP.0b013e3182954618

 

2012

Bauer, T., A. Zagorska, J. Jurkin, N. Yasmin, R. Koffel, S. Richter, B. Gesslbauer, G. Lemke, and H. Strobl. 2012. Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis. The Journal of experimental medicine 209: 2033-2047.

Drobits, B., M. Holcmann, N. Amberg, M. Swiecki, R. Grundtner, M. Hammer, M. Colonna, and M. Sibilia. 2012. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. The Journal of clinical investigation 122: 575-585.

Kalb, M. L., A. Glaser, G. Stary, F. Koszik, and G. Stingl. 2012. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. J Immunol 188: 1583-1591.

Niespodziana, K., K. Napora, C. Cabauatan, M. Focke-Tejkl, W. Keller, V. Niederberger, M. Tsolia, I. Christodoulou, N. G. Papadopoulos, and R. Valenta. 2012. Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26: 1001-1008.

 

2011

Eisenwort, G., J. Jurkin, N. Yasmin, T. Bauer, B. Gesslbauer, and H. Strobl. 2011. Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-beta1-dependent human epidermal Langerhans cells. The Journal of investigative dermatology 131: 2049-2057.

Niespodziana, K., M. Focke-Tejkl, B. Linhart, V. Civaj, K. Blatt, P. Valent, M. van Hage, H. Gronlund, and R. Valenta. 2011. A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. The Journal of allergy and clinical immunology 127: 1562-1570 e1566.

Schulten, V., I. Lauer, S. Scheurer, T. Thalhammer, and B. Bohle. 2011. A food matrix reduces digestion and absorption of food allergens in vivo. Molecular nutrition & food research 55: 1484-1491.

Schulten, V., B. Nagl, E. Scala, M. L. Bernardi, A. Mari, M. A. Ciardiello, I. Lauer, S. Scheurer, P. Briza, A. Jurets, F. Ferreira, B. Jahn-Schmid, G. F. Fischer, and B. Bohle. 2011. Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy 66: 1005-1013.

 

2009

Schulten, V., A. Radakovics, C. Hartz, A. Mari, S. Vazquez-Cortes, M. Fernandez-Rivas, I. Lauer, B. Jahn-Schmid, T. Eiwegger, S. Scheurer, and B. Bohle. 2009. Characterization of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach. The Journal of allergy and clinical immunology 124: 100-107.

 


 
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