Publications

2005

D'Cruz LM and Klein L. (2005). Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol., 11, 1152-9.

Kirchberger, S., Majdic, O., Steinberger, P., Bluml, S., Pfistershammer, K., Zlabinger, G., Deszcz, L., Kuechler, E., Knapp, W., and Stockl, J. (2005). Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. J Immunol 175 :1145.

Kriehuber, E., W. Bauer, A.-S. Charbonnier, D. Winter, G. Stingl, and Maurer, D. (2005). The balance between NF-?B and JNK/AP-1 activity controls dendritic cell life and death. Blood 106:175, 2005.

Krawczyk, C. M., Jones, R. G., Atfield, A., Bachmaier, K., Arya, S., Odermatt, B., Ohashi, P. S., and Penninger , J. M. Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J. Immunol. 174, 1472-1478. 2005.

2006

Kirchberger, S., Vetr, H., Majdic, O., Stockinger, H., and Stockl, J. (2006). Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1/ICAM-3 cell adhesion pathway in mononuclear phagocytes. Immunobiology 211:537.

Heinz LX, Platzer B, Reisner P, Jörgl A, Taschner S, Göbel F and Strobl H. (2006) Differential involvement of PU.1 and Id2 downstream of TGF-b1 during Langerhans cell commitment. Blood, 107(4):1445-53.

Alnaeeli, M., Penninger, J. M., and Yen-Tung A. Teng. Immune interactions with CD4 + T-cells promote the development of functional osteoclasts from murine CD11c + dendritic cells. J. Immunol. 177, 3314-3326, 2006.  

Rangachari, M., Mauermann, N., Marty, R., Dirnhofer, S., Kurrer, M. O., Komnenovic, V., Penninger, J. M. and Urs Eriksson. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J. Exp. Med. 203, 2009-2019. 2006.

Loser, K., Mehling, A., Loeser, S., Apelt, J., Kuhn, A., Grabbe, S., Schwarz, T., Penninger, J. M., and Stefan Beissert. Epidermal RANKL controls regulatory T cell numbers via activation of dendritic cells. Nature Med. 12, 1372-1379 . 2006.

Marty, R. R, Dirnhofer, S., Mauermann, N., Schweikert, S., Akira, S., Hunziker, L., Penninger, J. M., and Eriksson, U. MyD88 signaling controls autoimmune myocarditis induction. Circulation 113, 258-265. 2006 .

2007

Linhart, B., Bigenzahn, S., Hartl, A., Lupinek, C., Thalhamer, J., Valenta, R., and Wekerle, T. (2007). Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J Immunol 178:3924-31.

Pree, I. *, Bigenzahn, S. *, Fuchs, D., Koporc, Z., Nierlich, P., Winkler, C., Brandacher, G., Sykes, M., Muehlbacher, F., Langer, F., and Wekerle, T. (*contributed equally). (2007). CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of indoleamine-2,3-dioxygenase. Transplantation 83:663-7.

Koesters, C., Unger, B. Bilic, I., Bluml, S., Lichtenberger, B., Schreiber, M., Stockl, J. and Ellmeier, W. 2007. Regulation of dendritic cell differentiation, maturation and subset distribution by the zinc finger protein CTCF. Immunology Letters, 109, 165-74.

Aschenbrenner K, D'Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, Swee LK, Rolink A, Klein L. Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells. Nat Immunol., 4:351-8.

Jörgl, A., B. Platzer, S. Taschner, L. X. Heinz, B. Höcher, P. M. Reisner, F. Göbel, and H. Strobl. (2007). Human Langerhans cell activation triggered in vitro by conditionally expressed MKK6 is counter regulated by the downstream effector RelB. Blood, 109(1):185-93.

Taschner S, Koesters C, Platzer B, Jorgl A, Ellmeier W, Benesch, T, Strobl H. Downregulation of RXRa expression is essential for neutrophil development from granulocyte/monocyte progenitors. (2007). Blood, 109: 971-979.

Geyeregger, R., M. Zeyda, W. Bauer, E. Kriehuber, M.D. Saemann, G.J. Zlabinger, Maurer, D. and T.M. Stulnig. (2007). Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin bundling protein fascin. Blood 109:2488.

Meraner, P., V. Horejsi, A. Wolpl, G.F. Fischer, G. Stingl, and Maurer, D. (2007) Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation. J. Immunol. 178:2262.

Amatschek, S., E. Kriehuber, W. Bauer, B. Reininger, P. Meraner, A. Wolpl, N. Schweifer, C. Haslinger, G. Stingl, and Maurer, D. (2007). Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment. Blood 109:4777.

Winter, D., J. Moser , E. Kriehuber , C. Wiesner , R. Knobler , F. Trautinger , P. Bombosi, G. Stingl , P. Petzelbauer , A. Rot, and Maurer, D. (2007). Down-modulation of CXCR3 surface expression and function in CD8 + T cells from cutaneous T cell lymphoma patients. J. Immunol. 179:4272.

Loeser, S., Loser, K., Bijker, M. S., Rangachari, M., van der Burg, S. H., Wada, T., Beissert, S., Melief, C. J. M. and Josef M. Penninger. Spontaneous tumor rejection by cbl-b deficient CD8 + T cells. J. Exp. Med. 204, 879-891. 2007.

Rossi, S. W., Kim, M.-Y., Leibbrandt, A., Parnell, S. M., Jenkinson, W. E., Glanville, S. H., McConnell, F. M., Scott, H. S., Penninger, J. M., Jenkinson, E. J., Lane, P. J. L., and Graham Anderson. RANK signals from CD4 + 3 - inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J. Exp. Med. 11, 1267-1272. 2007.  

2008

Melcher M, Unger B, Schmidt U, Rajantie IA, Alitalo K, Ellmeier W. (2008). Essential Roles for the Tec Family Kinases Tec and Btk in M-CSF Receptor Signaling Pathways That Regulate Macrophage Survival. Journal of Immunology, 180: 8048-56.

Nedjic J.*, Aichinger M., Emmerich J., Mizushima N. and Klein L. (2008) Autophagy in thymic epithelium shapes the T cell repertoire and is essential for tolerance. Nature, 455, 394-400.

Raberger, J, Schebesta, A., Sakaguchi, S., Boucheron, N., Blomberg , K.M. , Berglöf , A. , Kolbe , T., Smith , C.I.E. , Rülicke , T. and Ellmeier, W. The Transcriptional Regulator PLZF Induces the Development of CD44-High Memory-Phenotype T Cells. 2008. PNAS, In press.

Raberger, J., Boucheron , N. , Sakaguchi, S., Penninger, J.M. and Ellmeier , W. Impaired T cell development in the absence of Vav1 and Itk. 2008. European Journal of Immunology, In press.

Reviews

Kyewski B. and Klein L. (2006) A central role for central T cell tolerance. Annual Reviews in Immunology, 24, 571-606.

Kirchberger, S., O. Majdic, and J. Stockl. (2006). Modulation of the Immune System by Human Rhinoviruses. Int Arch Allergy Immunol 142:1.

Bilic, I, and Ellmeier, W. (2007). The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunology Letters, 108, 1-9.

Pree, I., N. Pilat, and T. Wekerle. 2007. Recent progress in tolerance induction through mixed chimerism. Int Arch Allergy Immunol 144:254-66.

Cronin, S., and Penninger, J. M. From T cell activation signals to signaling control of anti-cancer immunity. Immunological Reviews 220 , 151-168. 2007.

Loeser, S., and Penninger, J. M. The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity. Cell Cycle 6 , 2478-2485 . 2007.

Loeser, S., and Josef M. Penninger. Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b . Seminars Immunol. 19, 206-214. 2007.

Alnaeeli, M., Park, J., Mahamed, D., Penninger, J. M., and Yen-Tung A. Teng. Dendritic cells at the osteo-immune interface: Implications for inflammation-induced bone loss. JBMR 22, 775-780, 2007.

Pree, I., N. Pilat, and T. Wekerle. 2008. Bone marrow transplantation as a strategy for tolerance induction: what steps are needed for large-scale clinical application? Front Biosci (in press).

Non SFB research highlights of SFB research groups

2005

Imai, I., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., Fukamizu, A., Crackower, M. A., Hui, C. C., Hein, L., Uhlig, S., Slutsky, A. S., Jiang, C., and Penninger, J. M. The SARS-coronavirus receptor ACE2 protects from severe acute lung failure. Nature, 436, 112-116. 2005.

Kuba, K., Imai, Y., Shuan Rao, Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Bao, L., Zhang, B., Huang, L., Liu, G., Wang, Z., Liu, Y., Zheng, D., Slutsky, A. S., Wada, T., Liu, D., Qin, C., Jiang, C., and Penninger, J. M. A critical role of angiotensin converting enzyme 2 (ACE2) in SARS pathogenesis. Nature Medicine, 11, 875-879. 2005.

Bigenzahn, S. , P. Blaha, Z. Koporc, I. Pree, E. Selzer, H. Bergmeister, F. Wrba, C. Heusser, K. Wagner, F. Muehlbacher, and T. Wekerle. 2005. The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. Am J Transplant 5:1237-1247.

Vincenti, F., C. Larsen, A. Durrbach, T. Wekerle, B. Nashan, G. Blancho, P. Lang,   J. Grinyo, P. F. Halloran, K. Solez, D. Hagerty, E. Levy, W. Zhou, K. Natarajan, and B. Charpentier, for the Belatacept Study Group. 2005. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 353:770-781.

2006

Danilczyk, U., Sarao, R., Remy, C., Benabbas, C., Stange, G., Richter, A., Arya, S., Pospisilik, J. A., Singer, D., Camargo, S. M. R., Makrides, V., Ramadan, T., Verrey, F., Wagner, C. A., and Josef M. Penninger. Essential role for Collectrin in renal amino acid transport. Nature, 444, 1088-1091. 2006.

Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Gu, Y., Sasaki, T., Suzuki, A., Forrester, J. V., Bourne, H. R., Devreotes, P. N.,   McCaig, C. D., and Josef M. Penninger. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 442, 457-460. 2006.  

Wagner B, Natarajan A, Grünaug S, Kroismayr R, Wagner EF, Sibilia M. 2006. Neuronal survival depends on EGF receptor signaling in cortical but not midbrain astrocytes. EMBO J. 25, 752-762.

Bilic, I., Kösters, K., Unger, B., Sekimata, M. Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W. (2006) Negative regulation of CD8 expression via CD8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nature Immunology, 4, 392-400.

2007

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Nakashima, T., Sarao, R., Neely, G., Esterbauer, H., Kozlov, A., Kahn, C. R., Kroemer, G., Rustin, P., Burcelin, R., and Josef M. Penninger.   Targeted deletion of AIF reductes mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 131, 476-491. 2007.

Natarajan A, Wagner B, Sibilia M. 2007. The EGF receptor is required for efficient liver regeneration. PNAS, 104:17081-17086

Aschenbrenner K., D'Cruz L.M., Vollmann E.H., Hinterberger M., Emmerich J., Swee L.K., Rolink A. and Klein L. (2007) Selection of Foxp3 + regulatory T cells specific for self-antigen expressed and presented by Aire + medullary thymic epithelial cells. Nature Immunology , 8 (4): 351-358.

2008

Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Lool, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., Liu, H., Sun, Y., Pasparakis, M., Kopf, M., mech, C., Bavari, S., Peiris, J. S. M., Slutsky, A. S., Akira, S., Hultqvist, M., Holmdahl, R., Nicholls, J., Jiang, C., Binder , C. J., and Josef M. Penninger. Identification of oxidative stress and Toll like receptor 4 signaling as a key pathway of acute lung injury. Cell 133 , 235-249 . 2008.  

Kirchberger S, Majdic O, Bluml S, Schrauf C, Leitner J, Gerner C, Paster W, Gundacker N, Sibilia M, Stöckl J. 2008. The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells, Blood. May 29, Epub ahead of print

Blüml, S., B. Rosc, A. Lorincz, S. Kirchberger, O. Oskolkova, V. Bochkov, O, Majdic, E. Ligeti, J. Stöckl The oxidation state of phospholipids controls oxidative burst formation in human neutrophil granulocytes. J.Immunology, in press (2008)