2005

2004

2003

2002

2001

Publications 2005

Bigenzahn, S., Blaha, P., Koporc, Z., Pree, I., Selzer, E., Bergmeister, H., Wrba, F., Heusser, C., Wagner, K., Muehlbacher, F., and Wekerle, T. The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. Am J Transplant 5 :1237-47 (2005).

Vincenti, F., Larsen, C., Durrbach, A., Wekerle, T., Nashan, B., Blancho, G., Lang, P., Grinyo, J., Halloran, P. F., Solez, K., Hagerty, D., Levy, E., Zhou, W., Natarajan, K., and Charpentier, B. for the belatacept study group. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 353:770-81 (2005).

Mai, G., Bucher, P., Morel, P., Mei, J., Bosco, D., Andres, A., Mathe, Z., Wekerle, T., Berney, T., and Buhler, L. H. Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. Transplant Proc 37:460-2 (2005).

Mai, G., Bucher, P., Morel, P., Mei, J., Bosco, D., Andres, A., Mathe, Z., Wekerle, T., Berney, T., and Buhler, L. H. Anti-CD154 mAb treatment but not recipient CD154 deficiency leads to long-term survival of xenogeneic islet grafts. Am J Transplant 5:1021-31 (2005).

Fehr, T., Takeuchi, Y., Kurtz, J., Wekerle, T., and Sykes, M. Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation. Eur J Immunol 35:2679-90 (2005).

Bucher, P., Mai, G., Morel, P., Mathe, Z., Bosco, D., Pernin, N., Wekerle, T., Berney, T., and Buhler, L. H. Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154. Transplantation 79:1545-52 (2005).

Blaha, P., Bigenzahn, S., Koporc, Z., Sykes, M., Muehlbacher, F., and Wekerle, T. Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after BMT without cytoreductive conditioning. Transplantation 80:237-43 (2005).

Andres, A., Toso, C., Morel, P., Bosco, D., Bucher, P., Oberholzer, J., Mathe, Z., Mai, G.,  Wekerle, T., Berney, T., and Buhler, L. H. Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation. Transplant Proc 37:463-5 (2005).

Andres, A., Toso, C., Morel, P., Bosco, D., Bucher, P., Oberholzer, J., Mathe, Z., Mai, G.,  Wekerle, T., Berney, T., and Buhler, L. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. Transplantation 79:543-9 (2005).

Publications 2004

Wekerle, T. and Sykes, M. Induction of tolerance. Surgery 135:359-64 (2004).

Takeuchi, Y., Ito, H., Kurtz, J., Wekerle, T., Ho, L., and Sykes, M. Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L. Am J Transplant 4:31-40 (2004).

Saemann, M. D., Zeyda, M., Stulnig, T., Böhmig, G. A., Wekerle, T., Hörl, W. H., and Zlabinger, G. Janus kinase-3 (JAK3) inhibition: a new immunosuppressive modality for allogeneic transplantation. Transpl Int 17:481-9 (2004).

Saemann, M., Muehlbacher, F., Zlabinger, G., and Wekerle, T. Selected commentary to: Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Europ Surgery 36:205-6 (2004).

Kurtz, J., Wekerle, T., and Sykes, M. Tolerance in mixed chimerism - a role for regulatory cells? Trends Immunol 25:518-23 (2004).

Heitger, A., Blaha, P., Bigenzahn, S., Muehlbacher, F., and Wekerle, T. The influence of immunosuppressive drugs on cell-induced graft tolerance. Curr Opin Organ Transplant 9:307-13 (2004).

Birsan, T., Loinig, C., Bodingbauer, M., Wekerle, T., Rockenschaub, S., Berlakovich, G., Soliman, T., Muehlbacher, F., and Steininger, R. Comparison between C0 and C2 monitoring in de novo renal transplant recipients: Retrospective analysis of a single center experience. Transplantation 78:1787-91 (2004).

Publications 2003

Blaha, P., Bigenzahn, S., Koporc, Z., Schmid, M., Langer, F., Selzer, E., Bergmeister, H., Wrba, F., Kurtz, J., Kiss, C. , Roth, E., Muehlbacher, F., Sykes, M., and Wekerle, T. The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 101:2886-93 (2003).

Wekerle, T., Blaha, P., Koporc, Z., Bigenzahn, S., Pusch, M., and Muehlbacher, F. Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral. Transplantation 75:21S-5S (2003).

Publications 2002

Wekerle, T., Nikolic, B., Pearson, D. A., Swenson, K. G., and Sykes, M. Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance. Transpl Int 15:248-53 (2002).

Wekerle, T., Kurtz, J., Bigenzahn, S., Takeuchi, Y., and Sykes, M. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol 14:592-600 (2002).

PWekerle, T., Blaha, P., Langer, F., Schmid, M., and Muehlbacher, F. Tolerance through bone marrow transplantation with costimulation blockade. Transpl Immunol 9:125-33 (2002).

Wekerle, T., Blaha, P., Asari, R., Schmid, M., Kiss, C., Roth, E., and Mühlbacher, F. Tolerance induction through mixed chimerism. Europ Surgery 34:131-5 (2002).

Publications 2001

Wekerle, T. and Sykes, M. Mixed chimerism and transplantation tolerance. Annu Rev Med 52:353-70 (2001).

T. Wekerle, J. Kurtz, M. Sykes, in Cardiac Allograft Rejection, G. W. Dec, J. Narula, M. Ballester, Carrió, Eds. (Kluwer Academic Publishers, 2001).

Wekerle, T., Kurtz, J., Sayegh, M. H., Ito, H., Wells, A. D., Bensinger, S., Shaffer, J., Turka, L. A., and Sykes, M. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol 166:2311-6 (2001).

T. Wekerle, C. Kiss, M. Bodingbauer, F. Langer, in Tacrolimus in der Herz- und Lungentransplantation, B. Reichart, Ed. (Pabst Science Publishers, 2001).

Wekerle, T. Transplantation tolerance induced by mixed chimerism. J Heart Lung Transplant 20:816-23 (2001).

Kurtz, J., Ito, H., Wekerle, T., Shaffer, J., and Sykes, M. Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: Lack of requirement for CD40L-mediated signaling for tolerance or deletion or donor-reactive CD4+ cells. Am J Transplant 1:339-49 (2001).