Publications 2010

Pilat, N. and Wekerle, T. Mechanistic and therapeutic role of regulatory T cells in tolerance through mixed chimerism. Curr Opin Organ Transplant. 15:725-730 (2010)

Pilat, N. and Wekerle, T. Transplantation tolerance through mixed chimerism. Nat Rev Nephrol. 6:594-605 (2010)

Pilat,N. and Wekerle,T. Combining Treg therapy with mixed chimerism: getting the best of both worlds Chimerism 1:26-29 (2010)

Vincenti, F., Blancho, G., Durrbach, A., Friend, P., Grinyo, J., Halloran, P.F., Klempnauer, J., Lang, P., Larsen, C.P., Mühlbacher, F., Nashan, B., Soulillou, J.P., Vanrenterghem, Y., Wekerle, T., Agarwal, M., Gujrathi, S., Shen, J., Shi, R., Townsend, R. and Charpentier, B. Five-year safety and efficacy of belatacept in renal transplantation. J Am Soc Nephrol. 21:1587-1596 (2010)

Muller, Y.D., Mai, G., Morel, P., Serre-Beinier, V., Gonelle-Gispert, C., Yung, G.P., Ehirchiou, D., Wyss, J.C., Bigenzahn, S., Irla, M., Heusser, C., Golshayan, D., Seebach, J.D., Wekerle, T., Bühler, L.H. Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation. PLoS One. 5:e10352 (2010)

Pilat, N., Baranyi, U., Klaus, C., Jaeckel, E., Mpofu, N., Wrba, F., Golshayan, D., Muehlbacher, F. and Wekerle, T. Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. Am J Transplant.10:751-762 (2010)

Nierlich, P.N., Klaus, C., Bigenzahn, S., Pilat, N., Koporc, Z., Pree, I, Baranyi, U, Taniguchi, M, Muehlbacher, F. and Wekerle T. The role of natural killer T cells in costimulation blockade-based mixed chimerism. Transpl Int. 23:1179-1189 (2010)

Publications 2009

Pree, I., Pilat, N., and Wekerle, T. Bone marrow transplantation as a strategy for tolerance induction: what steps are needed for large-scale clinical application? Front Biosci 14:611-620 (2009).

Pilat, N.; Klaus, C.; Schwaiger, E., and Wekerle, T. Hurdles to the induction of tolerogenic mixed chimerism. Transplantation. 87(Suppl.9):79-84 (2009)

Publications 2008

Baranyi, U., Linhart, B., Pilat, N., Bagley, J., Muehlbacher, F., Iacomini, J., Valenta, R., and Wekerle, T. Tolerization of a type I allergic immune response through transplantation of genetically modified hematopoietic stem cells. J Immunol 180: 8168-8175 (2008).

Koporc, Z., Pilat, N., Nierlich, P., Blaha, P., Bigenzahn, S., Pree, I., Selzer, E., Sykes, M., Muehlbacher, F., and Wekerle, T. Murine peripheral blood stem cells have a lower capacity than bone marrow to induce mixed chimerism and tolerance. Am J Transplant 8:2025-2036 (2008).

Misof, B. M. , Bodingbauer, M., Roschger, P., Wekerle, T., Pakrah, B., Haas, M., Kainz, A., Oberbauer, R., Muehlbacher, F., and Klaushofer, K. Short-term effects of high dose zoledronic acid treatment on bone mineralization density distribution (BMDD) after orthotopic liver transplantation. Calcif Tissue Int 83(3):167-175 (2008).

Fehr, T., Wang, S., Haspot, F., Kurtz, J., Blaha, P., Hogan, T., Chittenden, M., Wekerle, T., and Sykes, M. Rapid, deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells. J Immunol 181(6):4371-4380 (2008).

Mai, G., Andres, A., Morel, P., Mei, J., Gonelle, C., Beinier, V., Heusser, C., Bigenzahn, S., Wekerle, T. and Buhler, L. Tolerance induction to xenogeneic islets by anti-CD154 mAb and rapamycin is based on anergy and regulation.(2008) (submitted).

Wekerle, T. 2008. T regulatory cells - what relationship with immunosuppressive agents? Transplant Proc 40(Suppl. 10):13-6 (2008).

Publications 2007

Pree, I. and Wekerle, T. Inducing mixed chimerism and transplantation tolerance through allogeneic bone marrow transplantation with costimulation blockade. Methods in molecular biology 380:391-403 (2007)

Silberhumer, G., Pokorny, H., Hetz, H., Herkner, H., Rasoul-Rockenschaub, S., Soliman, T., Wekerle, T., Berlakovich, G., Steininger, R., and Muehlbacher, F. Combination of extended donor criteria and changes in the model for end-stage liver disease score predict patient survival and primary dysfunction in liver transplantation: A retrospective analysis. Transplantation 83:588-92 (2007).

Pree, I., Pilat, N., and Wekerle, T. Recent progress in tolerance induction through mixed chimerism. Int Arch Allergy Immunol 144:254-66 (2007).

Pree, I. *, Bigenzahn, S. *, Fuchs, D., Koporc, Z., Nierlich, P., Winkler, C., Brandacher, G., Sykes, M., Muehlbacher, F., Langer, F., and Wekerle, T. CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of indoleamine-2,3-dioxygenase. Transplantation 83:663-7 (2007). *contributed equally

Linhart, B., Bigenzahn, S., Hartl, A., Lupinek, C., Thalhamer, J., Valenta, R., and Wekerle, T. Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J Immunol 178:3924-31 (2007).

Hainz, U., Jurgens, B., Seidel, M. G., Wekerle, T., and Heitger, A. Indoleamine 2,3-dioxygenase in hematopoietic stem cell transplantation. Curr Drug Metab 8:267-72 (2007).

Bodingbauer, M., Wekerle, T., Pakrah, B., Roschger, P., Peck-Radosavljevic, M., Silberhumer, G., Grampp, S., Rockenschaub, S., Berlakovich, G., Steininger, R., Klaushofer, K., Oberbauer, R., and Muehlbacher, F. Prophylactic bisphosphonate treatment prevents bone fractures after liver transplantation. Am J Transplant 7:1763-9 (2007).

Pree, I. *, Bigenzahn, S. *, Fuchs, D., Koporc, Z., Nierlich, P., Winkler, C., Brandacher, G., Sykes, M., Muehlbacher, F., Langer, F., and Wekerle, T. *contributed equally. CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of indoleamine-2,3-dioxygenase. Transplantation 83:663-7 (2007).

Bodingbauer, M., Kramar, R., Wekerle, T., Boehmig, G., Berlakovich, G., Saemann, M., Steininger, R., Perco, P., Oberbauer, R., Hoerl, W., and Muehlbacher, F. Present status at the Vienna transplantation center after four thousand renal transplantations. Clin Transplant. 2007:69-80.

Publications 2006

Perco*, P., Blaha*, P., Kainz, A., Mayer, B., Hauser, P., Wekerle, T., and Oberbauer, R. Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade. Transpl Int 19:146-57 (2006). *co-first authors.

Pree, I. and Wekerle, T. New approaches to prevent transplant rejection: Costimulation blockers anti-CD40L and CTLA4Ig. Drug Discovery Today: Therapeutic Strategies 3:41-7 (2006).

Koporc, Z., Bigenzahn, S., Blaha, P., Fariborz, E., Selzer, E., Sykes, M., Muehlbacher, F., and Wekerle, T. Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation. Biol Blood Marrow Transplant 12:284-92 (2006).

Bodingbauer, M., Pakrah, B., Steininger, R., Berlakovich, G., Rockenschaub, S., Wekerle, T., and Muehlbacher, F. The advantage of allocating kidneys from old cadaveric donors to old recipients: a single-center experience. Clin Transplant 20:471-5 (2006).