Selected Articles

Farkas, A. M., Baranyi, U., Bohmig, G. A., Unger, L., Hopf, S., Wahrmann, M., Regele, H., Mahr, B., Schwarz, C., Hock, K., Pilat, N., Kristo, I., Mraz, J., Lupinek, C, Thalhamer, J., Bond, G., Kuessel, L., Wlodek, E., Martin, J., Clatworthy, M., Pettigrew, G., Valenta, R. and Wekerle, T. 2019. Allograft rejection is associated with development of functional IgE specific for donor MHC antigens. J Allergy Clin Immunol;143(1):335-45 e12; 10.1016/j.jaci.2018.06.034

Wekerle, T., Segev, D., Lechler, R. and Oberbauer, R. 2017. Strategies for long-term preservation of kidney graft function. Lancet;389(10084):2152-62; 10.1016/S0140-6736(17)31283-7

Granofszky, N., Farkas, A. M., Muckenhuber, M., Mahr, B., Unger, L., Maschke, S., Pilat, N., Holly, R., Wiletel, M., Regele, H. and Wekerle, T. 2017. Anti-Interleukin-6 Promotes Allogeneic Bone Marrow Engraftment and Prolonged Graft Survival in an Irradiation-Free Murine Transplant Model. Front Immunol;8:821; 10.3389/fimmu.2017.00821

Duran-Struuck, R., Sondermeijer, H. P., Buhler, L., Alonso-Guallart, P., Zitsman, J., Kato, Y., Wu, A., McMurchy, A. N., Woodland, D., Griesemer, A., Martinez, M., Boskovic, S., Kawai, T., Cosimi, A. B., Wuu, C. S., Slate, A., Mapara, M. Y., Baker, S., Tokarz, R., D'Agati, V., Hammer, S., Pereira, M., Lipkin, W. I., Wekerle, T., Levings, M. K. and Sykes, M. 2017. Effect of Ex Vivo-Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques. Transplantation 101(2):274-83; 10.1097/TP.0000000000001559

 

Pilat, N. and Wekerle, T. 2010. Transplantation tolerance through mixed chimerism: insights from preclinical and clinical studies. Nature Rev Nephrol 6: 594-605.

Pilat, N., Baranyi, U., Klaus, C., Jaeckel, E., Mpofu, N., Wrba, F., Golshayan, D., Muehlbacher, F., and T. Wekerle. 2010. Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. Am J Transplant 10:751-62.

Vincenti, F., Larsen, C., Durrbach, A., Wekerle, T., Nashan, B., Blancho, G., Lang, P., Grinyo, J., Halloran, P. F., Solez, K., Hagerty, D., Levy, E., Zhou, W., Natarajan, K., and Charpentier, B. for the belatacept study group. 2005. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 353:770-81.

Blaha, P., Bigenzahn, S., Koporc, Z., Schmid, M., Langer, F., Selzer, E., Bergmeister, H., Wrba, F., Kurtz, J., Kiss, C., Roth, E., Muehlbacher, F., Sykes, M., and T. Wekerle. 2003. The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 101:2886-93.

Wekerle, T., Kurtz, J., Ito, H., Ronquillo, J. V., Dong, V., Zhao, G., Shaffer, J., Sayegh, M. H., and Sykes, M. 2000. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nature Med 6:464-9.

Wekerle, T., Sayegh, M. H., Hill, J., Zhao, Y., Chandraker, A., Swenson, K. G., Zhao, G., and Sykes, M. 1998. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med 187:2037-44.