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SEVENTH FRAMEWORK PROGRAMME

Medical University of Vienna

Medical University of Vienna
Clinical Institute of Pathology
Währinger Gürtel 18-20
1090 Vienna

MUW website http://www.meduniwien.ac.at/homepage/
Department´s website http://www.meduniwien.ac.at/klinpath/

Coordinator and Scientist-in-charge


Prof. Andrew Rees Prof. Andrew Rees
Professorial Fellow, Clinical Department of Pathology, Medical University of Vienna, Austria 
Phone: +43(1) 40400-3681 
Fax: +43(1) 40400-5193 
E-Mail to Prof. Andrew Rees Contact  

Andy Rees holds a Professorial Fellowship at the Clinical Institute of Pathology, Medical University of Vienna. He qualified in Medicine in Liverpool and trained in internal medicine and nephrophrology in London first with Stewart Cameron at Guys Hospital and then with Keith Peters at Royal Postgraduate Medical School. He became a Senior Lecturer at RPMS and subsequently Professor of Nephrology and head of the unit. In 2004, he was appointed Regius Professor in Medicine at Aberdeen University. He moved to Vienna in 2007. Throughout his career, Professor Rees' research has focussed on the clinical and pathogenetic aspects of glomerulonephritis - especially the various types of focal necrotizing glomerulonephritis. His current work concentrates on autoimmunity to glomerular proteins in pauci-immune FNGN and the role of differential macrophage activation in executing the injury it causes. He is a Fellow of the Academy of Medical Sciences and the Society of Biologists in the UK. He chairs the European Vasculitis Genetics Consortium and the European Kidney Health Alliance.
  

Publications:

Publications http://www.ncbi.nlm.nih.gov/pubmed?term=%22Rees%20AJ%22%5BAuthor%5D




Project Supervisor / Network Training Officer


Prof. Renate Kain Prof. Renate Kain
Clinical Department of Pathology, Medical University of Vienna, Austria 
Phone: +43(1) 40400-3681 
Fax: +43(1) 40400-5193 
E-Mail to Prof. Renate Kain Contact  

Dr Renate Kain qualified in Medicine in Vienna before training in general and renal pathology with Dontschko Kerjaschki in Vienna and Michael Mihatsch in Basel. Since 1992 she is a Consultant Histopathologist with special expertise in renal pathology and a particular interest in small vessel vasculitis. After training in renal cell biology in Vienna, she expanded her research expertise in molecular biology and glycobiology with Minoru Fukuda at the Burnham Institute, La Jolla, California as Max Kade and Erwin Schrödinger postdoctoral fellow. In 1999 she became a Kidney Research UK Senior Research Fellow at Aberdeen University where she remained until returning to her present post in Clinical Institute of Pathology at the Medical University in Vienna. She made the original discovery of autoantibodies to human lysosomal membrane protein-2 (hLAMP-2) in vasculitis and has recently shown they are pathogenic. Dr Kain has considerable expertise in basic immunological and pathological research and her research focuses on glycoproteins as targets for autoimmunity in glomerulonephritis.
   

Publications:

Publications http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kain%20R%22%5BAuthor%5D



Project Supervisor


Prof. Dontscho Kerjaschki Prof. Dontscho Kerjaschki
Head of Department, Clinical Department of Pathology, Medical University of Vienna, Austria 
Phone: +43(1) 40400-5175 
Fax: +43(1) 40400-5193 
E-Mail to Prof. Dontscho Kerjaschki Contact  

Dontscho Kerjaschki, M.D. is Professor and Chairman of the Clinical Institute of Pathology of the University of Vienna that is staffed with 35 pathologists and 150 non academic personnel. After his training as a pathologist, Dr Kerjaschki spent four years as Postdoctoral Fellow, and the following six years as Visiting Professor in the Department of Cell Biology, Yale University, New Haven, CT. Since 1990 he has been Visiting Research Fellow in the Department of Cellular and Molecular Medicine, University of California, San Diego.
Dr Kerjaschki has received the Volhard Preis of the German Society of Nephrology. Since 1994 Dr Kerjaschki has been a Fellow of the Royal College of Physicians in Edinburgh. He is a Member of the German National Academy of Sciences Leopoldina, and holds a Honorary Degree from the University of Erlangen. He is an Associate Editor for the American Journal of Pathology. His research is funded by the Austrian Research Fund, the NIH and the European Community. Dr Kerjaschki regularly reviews project program grants for the Austrian, the Swiss, the Australian and the German Research Funds, INSERM, the Wellcome Trust, and the NIH.


Principal Research Interests:

Pathology of cell biology of the renal glomerulus and lymphatic endothelium. He discovered and defined their roles in glomerular immune complex diseases, glomerular damage and proteinuria. He is a leading expert in the nascent field of human lymphatic biology and pathology and has discovered the first reliable marker for lymphatic endothelial cells that has opened new avenues of investigative human pathology, ranging from renal transplant rejection to cancer metastasis.


Publications:

Publications http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kerjaschki%20D%22%5BAuthor%5D


Institute Presentation


The Medical University of Vienna is the largest medical research institution in Austria. It was founded in 1365 as a Medical Faculty of the University of Vienna and has operated as an independent institution in the scope of autonomous university and self administration since 2004.
The Clinical Institute of Pathology in the Medical University of Vienna is one of the foremost Pathology research institutes in the world. Located in the General Hospital, the Institute's clinical workload exceeds 35000 histological requests and provides clinical services to the community of Vienna at the forefront of diagnostic methodology including conventional histology, immunohistochemistry and electron microscopy but also develops novel approaches such as molecular analysis and cytogenetics.


Training

The Clinical Institute of Pathology will provide the Technical Platform for tissue imaging together with a tissue bank of archived biopsies from patients with all types of renal inflammation and renal cancers. In addition, the group has extensive expertise in renal cell biology and immunology and in the creation and use of rodent models of renal inflammation. The Scientist-in-charge (Rees) is a Professorial Fellow and a renal immunologist with an international reputation for his clinical and experimental studies for autoimmune disease including small vessel systemic vasculitis. Kerjaschki is Head of the Institute and an experienced renal pathologist whose research combines state-of-the-art ultrastructural studies with molecular biology and protein analysis. He discovered the phenomenon of inflammation induced lymphangiogenesis and is at the forefront in the drive to elucidate its role in disease. Kain is also an expert renal pathologist with a special interest in small vessel vasculitis and considerable expertise in cell biology. She made the original discovery of autoantibodies to human lysosomal membrane protein-2 (hLAMP-2) in vasculitis and has recently shown they are pathogenic. Dr Kain has considerable expertise in the skills required of a Network Training Officer having fulfilled a very similar role within the Institute of Clinical Pathology when she co-ordinated undergraduate training programmes for a 4-year period.

Medical University of Vienna