College of the Holy and Undivided Trinity of Queen Elizabeth
Department of Biochemistry
School of Biochmistry and Immunology
College Green
Dublin, Ireland
http://www.biochemistry.tcd.ie/
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Prof Luke O´Neill Professor of Biochemistry, School of Biochemistry and Immunology, Trinity College Dublin, Ireland Phone: +35 31 896 2439 Fax: +35 31 6772400  Contact |
Prof O´Neill´s website: http://www.tcd.ie/Biochemistry/research/l_o_neill.php
The major focus of the group is to provide a molecular understanding of innate immunity and inflammation. We are interested in receptors involved in innate immunity, such as Toll-like receptors and Nod-like receptors, and also signals activated, including NF-kappaB, IRF family transcription factors and MAP kinases. The role played by this system in inflammatory conditions such as sepsis syndrome and rheumatoid arthritis is also under investigation.
http://www.ncbi.nlm.nih.gov/pubmed?term=%22O'Neill%20LA%22%5BAuthor%5D
The School was formed in 2005 as a result of restructuring in Trinity College Dublin, and comprises the 2 disciplines of Biochemistry and Immunology. We are a dynamic research-led School, with extensive undergraduate and post-graduate teaching programmes.
In research there are currently 21 research laboratories in the School, with a total level of research funding of €34m. The areas of research in Biochemistry include Enzymology, Folic Acid Biochemistry, Structural Biology, Neurochemistry, Molecular Parasitology and Energy Transduction. In Immunology we are active in Immunoregulation, Immunomodulation, Cell signalling in immunity and inflammation, Immunoparasitology, Innate Immunity and Inflammation, and Viral subversion of Immunity. We have a total equipment base of over € 20m, with all the major technologies in Biochemistry and Immunology available.
Dublin will supply the Technical Platform for immune cell signalling and for biochemistry more generally. The Scientist-in-charge (O'Neill) heads the Immunology Group in the Department of Biochemistry. He is an authority on the molecular and cellular basis to inflammation and innate immunity with a particular interest in the signal transduction of Toll-like receptors and in molecular analysis of inflammatory and infectious diseases.
Consortium
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