SPTM    Institute of Specific Prophylaxis and Tropical Medicine, Medical University Vienna, Kinderspitalgasse 15, A-1090 Vienna
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GASTPROFESSOREN

Prof. Dr. Walther H. Wernsdorfer
A d r e s s e:
Kinderspitalgasse 15, A-1090 Wien
Tel: +43-1-40 160-38291

Fax.: +43-1-40 160-938293

Email: walter.wernsdorfer@meduniwien.ac.at

 

 


 

 

Bettina Exner

Maria Parizek

Peter Starzengruber

Oumaporn Tasanor

Armin Sadjed

Benedikt Ley

Gernot Müller

 

N E W S

 

Derzeit keine

 

 

F O R S C H U N G S P R O J E K T E

 

A. Ongoing projects

 

  • Monitoring of in vitro drug response of Plasmodium falciparum in northern Thailand near the border to Myanmar (Mae Sot, Tak Province)
  • Investigation of the pharmacodynamic interaction between antimalarial drugs belonging to different chemical groups (Plasmodium falciparum)
  • Investigation of the pharmacodynamic interaction between antimalarial drugs and potential enhancers other than antimalarials, e.g. retinol (P. falciparum)
  • Monitoring of in vitro drug response of Plasmodium vivax to chloroquine and alternative antimalarial drugs the use of which could be considered in the case of resistance to chloroquine
  • Evaluation of the in vitro activity of plant-derived extracts and pure, structurally characterized substances in Plasmodium falciparum and Plasmodium vivax
  • Pharmacokinetics of antimalarial compounds
  • Genetic markers of drug resistance in Plasmodium falciparum
  • Surveillance of malaria, dengue and Japanese encephalitis and prevention of transmission in a vulnerable area heavily exposed to the importation of infective reservoir.

      B. Newly initiated projects

 

              

  • Implementation of sero-epidemiological surveys (malaria) in former foci of active transmission and in newly arriving immigrants to a receptive area heavily exposed to the importation of infective reservoir;
  • Development of an in vitro model for biological and chemotherapeutic research with Crithidia fasciculata as a representative of the family Trypanosomatidae.

 

 

K O O P E R A T I O N E N

 

National cooperations

Department of Chemical Ecology and Ecosystem Research, Vienna Ecology Center, Faculty of Science, University of Vienna (antiprotozoal activity of plant-derived substances).

Department of comparative anthropology, Vienna Biology Center, Faculty of Science, University of Vienna.

 


Interational cooperations

 

World Health Organization, Headquarters, Geneva: WHO Expert Committee for Malaria (WHW is chairman of the committee).

World Health Organization, Regional Office for the Eastern Mediterranean: development of a surveillance system for malaria, dengue and Japanese encephalitis in an area heavily exposed to the importation of infective reservoir.

Ministry of Public Health, Nonthaburi, Thailand: Monitoring of drug sensitivity of Plasmodium falciparum and Plasmodium vivax. Gene polymorphisms and drug sensitivity of Plasmodium falciparum.

Department of Infectious Diseases, Karolinska Hospital and Karolinska Institute, Stockholm: Drug interactions, mechanisms of drug activity, and gene polymorphisms in Plasmodium falciparum.

Department of Biomedical Technology, Clinical Pharmacology, Faculty of Allied Health Sciences, Thammasat University, Rangsit Campus, Bangkok: Pharmacokinetics of antimalarial and antifilarial drugs. Clinical-parasitological response of Plasmodium vivax.

Centre for Drug Research, Universiti Sains Malaysia, Penang: development of assay methods for antiparasitic medicaments in biological material. Phase I clinical trials.

Central Malaria Department, Ministry of Public Health of the United Arab Emirates, Sharjah, UAE: sero-epidemiological investigations (malaria).

 

P U B L I K A T I  O N E N

 

Ramanathan S, Karupiah S, Nair NK, Olliaro PL, Navaratnam V, Wernsdorfer WH, Mansor SM 2005. A new and simple solid-phase extraction method for LC determination of pyronaridine in human plasma. J Chromatography B 824:45-50

Congpuong K, Na-Bangchang K, Mungthin M, Bualombei P, Wernsdorfer WH 2005. Molecular epidemiology of drug resistance markers of Plasmodium falciparum malaria in Thailand. Trop Med Int Health 10: 717-722

Mariga ST, Gil JP, Wernsdorfer WH, Björkman A 2005. Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro. Acta Tropica 93: 221-231

Rojanawatsirivet C, Congpuong K, Vijaikadga S, Tongphua S, Thongsri K, Bangchang KN, Wilairatana P, Wernsdorfer WH 2004. Declining mefloquine sensitivity of Plasmodium falciparum along the Thai-Myanmar border. Southeast Asian J Trop Med. Public Health 35: 560-565 

Samal D, Rojanawatsirivet, Wernsdorfer G, Kollaritsch H, Sirichaisinthop J, Wernsdorfer WH 2005. Synergism of desbutyl-benflumetol and retinol against Plasmodium falciparum in vitro. Wien Klin Wschr 117 (Suppl 4): 39-44

Thriemer K, Wernsdorfer G, Rojanawatsirivet C, Kollaritsch H, Sirichaisinthop J, Wernsdorfer WH 2005. In vitro activity of artemisinin alone and in combination with retinol against Plasmodium falciparum. Wien Klin Wschr 117 (Suppl 4): 45-48

Knauer A, Das AK, Tansuphasawadikul S, Supanaranond W, Pitisuttithum P, Wernsdorfer WH 2005. Clinical features, aetiology and short-term outcome of interstitial pneumonitis in HIV/AIDS patients at Bamrasnaradura hospital, Nonthaburi, Thailand.
Wien Klin Wschr 117 (Suppl 4): 49-55; IP: 0,91


 

A K T I V I T Ä T E N

 

Derzeit keine