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GASTPROFESSOREN
Prof. Dr. Walther H. Wernsdorfer
A d r e s s
e:
Kinderspitalgasse
15, A-1090 Wien
Tel: +43-1-40 160-38291
Fax.: +43-1-40 160-938293
Email: walter.wernsdorfer@meduniwien.ac.at
Bettina Exner
Maria Parizek
Peter Starzengruber
Oumaporn Tasanor
Armin Sadjed
Benedikt Ley
Gernot
Müller
N E W S
Derzeit keine
F O R S C H U N G S P R O J E K T
E
A. Ongoing projects
- Monitoring of in vitro
drug response of Plasmodium
falciparum in northern Thailand near the border to
Myanmar (Mae Sot, Tak Province)
- Investigation of the
pharmacodynamic interaction between antimalarial drugs belonging to different
chemical groups (Plasmodium
falciparum)
- Investigation of the
pharmacodynamic interaction between antimalarial drugs and potential
enhancers other than antimalarials, e.g. retinol (P. falciparum)
- Monitoring of in vitro
drug response of Plasmodium vivax
to chloroquine and alternative antimalarial drugs the use of which
could be considered in the case of resistance to chloroquine
- Evaluation of the in
vitro activity of plant-derived extracts and pure, structurally
characterized substances in Plasmodium
falciparum and Plasmodium
vivax
- Pharmacokinetics of
antimalarial compounds
- Genetic markers of drug
resistance in Plasmodium
falciparum
- Surveillance of
malaria, dengue and Japanese encephalitis and prevention of
transmission in a vulnerable area heavily exposed to the importation
of infective reservoir.
B. Newly initiated projects
- Implementation of
sero-epidemiological surveys (malaria) in former foci of active
transmission and in newly arriving immigrants to a receptive area heavily
exposed to the importation of infective reservoir;
- Development of an in
vitro model for biological and chemotherapeutic research with Crithidia fasciculata as a
representative of the family Trypanosomatidae.
K O O P E R A T I O N E N
National cooperations
Department of Chemical Ecology and Ecosystem
Research, Vienna Ecology Center, Faculty of Science, University of Vienna
(antiprotozoal activity of plant-derived substances).
Department of comparative
anthropology, Vienna Biology Center,
Faculty of Science, University
of Vienna.
Interational cooperations
World Health Organization,
Headquarters, Geneva:
WHO Expert Committee for Malaria (WHW is chairman of the committee).
World Health Organization, Regional
Office for the Eastern Mediterranean:
development of a surveillance system for malaria, dengue and Japanese
encephalitis in an area heavily exposed to the importation of infective
reservoir.
Ministry of Public Health, Nonthaburi, Thailand: Monitoring of drug
sensitivity of Plasmodium
falciparum and Plasmodium
vivax. Gene polymorphisms and drug sensitivity of Plasmodium falciparum.
Department of Infectious Diseases, Karolinska Hospital
and Karolinska Institute, Stockholm:
Drug interactions, mechanisms of drug activity, and gene polymorphisms in Plasmodium falciparum.
Department of Biomedical Technology,
Clinical Pharmacology, Faculty of Allied Health Sciences, Thammasat
University, Rangsit Campus, Bangkok: Pharmacokinetics of antimalarial and
antifilarial drugs. Clinical-parasitological response of Plasmodium vivax.
Centre for Drug Research, Universiti
Sains Malaysia, Penang: development of assay methods for
antiparasitic medicaments in biological material. Phase I clinical trials.
Central Malaria Department,
Ministry of Public Health of the United Arab Emirates, Sharjah,
UAE: sero-epidemiological investigations (malaria).
P U B L I K A T I O N E N
Ramanathan S, Karupiah S, Nair NK, Olliaro PL, Navaratnam V,
Wernsdorfer WH, Mansor SM 2005. A new and simple solid-phase extraction method
for LC determination of pyronaridine in human plasma. J Chromatography B
824:45-50
Congpuong K, Na-Bangchang K, Mungthin M, Bualombei P, Wernsdorfer WH 2005.
Molecular epidemiology of drug resistance markers of Plasmodium falciparum
malaria in Thailand.
Trop Med Int Health 10: 717-722
Mariga ST, Gil JP, Wernsdorfer WH, Björkman A 2005. Pharmacodynamic
interactions of amodiaquine and its major metabolite desethylamodiaquine
with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro.
Acta Tropica 93: 221-231
Rojanawatsirivet C, Congpuong K, Vijaikadga S, Tongphua S, Thongsri K,
Bangchang KN, Wilairatana P, Wernsdorfer WH 2004. Declining mefloquine
sensitivity of Plasmodium falciparum along the Thai-Myanmar border.
Southeast Asian J Trop Med. Public Health 35: 560-565
Samal D, Rojanawatsirivet, Wernsdorfer G, Kollaritsch H, Sirichaisinthop J,
Wernsdorfer WH 2005. Synergism of desbutyl-benflumetol and retinol against
Plasmodium falciparum in vitro. Wien Klin Wschr 117 (Suppl 4): 39-44
Thriemer K, Wernsdorfer G, Rojanawatsirivet C, Kollaritsch H,
Sirichaisinthop J, Wernsdorfer WH 2005. In vitro activity of artemisinin
alone and in combination with retinol against Plasmodium falciparum. Wien
Klin Wschr 117 (Suppl 4): 45-48
Knauer A, Das AK, Tansuphasawadikul S, Supanaranond W, Pitisuttithum P,
Wernsdorfer WH 2005. Clinical features, aetiology and short-term outcome of
interstitial pneumonitis in HIV/AIDS patients at Bamrasnaradura hospital, Nonthaburi, Thailand. Wien Klin Wschr 117 (Suppl 4): 49-55;
IP: 0,91
A K T I V I T Ä T E N
Derzeit keine
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