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GASTPROFESSOREN
Prof. Dr. Walther H. Wernsdorfer
A d r e s s
e:
Kinderspitalgasse
15, A-1090 Wien
Tel: +43-1-40 490-64890
Fax.: +43-1-40 490-64889
Email: walter.wernsdorfer@meduniwien.ac.at
Bettina Exner
Maria Parizek
Peter
Starzengruber
Oumaporn Tasanor
Armin Sadjed
Benedikt Ley
Gernot
Müller
N E W S
Derzeit keine
F O R S C H U N G S P R O J E K T
E
A. Ongoing projects
- Monitoring of in vitro
drug response of Plasmodium
falciparum in northern Thailand near the border to
Myanmar (Mae Sot, Tak Province)
- Investigation of the
pharmacodynamic interaction between antimalarial drugs belonging to
different chemical groups (Plasmodium
falciparum)
- Investigation of the
pharmacodynamic interaction between antimalarial drugs and potential
enhancers other than antimalarials, e.g. retinol (P. falciparum)
- Monitoring of in vitro
drug response of Plasmodium vivax
to chloroquine and alternative antimalarial drugs the use of which
could be considered in the case of resistance to chloroquine
- Evaluation of the in
vitro activity of plant-derived extracts and pure, structurally
characterized substances in Plasmodium
falciparum and Plasmodium
vivax
- Pharmacokinetics of
antimalarial compounds
- Genetic markers of drug
resistance in Plasmodium
falciparum
- Surveillance of
malaria, dengue and Japanese encephalitis and prevention of
transmission in a vulnerable area heavily exposed to the importation
of infective reservoir.
B. Newly initiated projects
- Implementation of
sero-epidemiological surveys (malaria) in former foci of active
transmission and in newly arriving immigrants to a receptive area
heavily exposed to the importation of infective reservoir;
- Development of an in
vitro model for biological and chemotherapeutic research with Crithidia fasciculata as a
representative of the family Trypanosomatidae.
K O O P E R A T I O N E N
National cooperations
Department of Chemical Ecology and Ecosystem
Research, Vienna Ecology Center, Faculty of Science, University of Vienna
(antiprotozoal activity of plant-derived substances).
Department of comparative
anthropology, Vienna Biology Center, Faculty of Science, University of Vienna.
Interational cooperations
World Health Organization, Headquarters,
Geneva: WHO Expert Committee for Malaria (WHW is
chairman of the committee).
World Health Organization, Regional
Office for the Eastern
Mediterranean: development of
a surveillance system for malaria, dengue and Japanese encephalitis in an
area heavily exposed to the importation of infective reservoir.
Ministry of Public Health, Nonthaburi,
Thailand: Monitoring of drug sensitivity of Plasmodium falciparum and Plasmodium vivax. Gene polymorphisms
and drug sensitivity of Plasmodium
falciparum.
Department of Infectious Diseases,
Karolinska Hospital and Karolinska Institute, Stockholm: Drug interactions,
mechanisms of drug activity, and gene polymorphisms in Plasmodium falciparum.
Department of Biomedical Technology,
Clinical Pharmacology, Faculty of Allied Health Sciences, Thammasat
University, Rangsit Campus, Bangkok: Pharmacokinetics of antimalarial and
antifilarial drugs. Clinical-parasitological response of Plasmodium vivax.
Centre for Drug Research, Universiti
Sains Malaysia, Penang: development of assay methods for antiparasitic
medicaments in biological material. Phase I clinical trials.
Central Malaria Department,
Ministry of Public Health of the United Arab Emirates, Sharjah, UAE: sero-epidemiological
investigations (malaria).
P U B L I K A T I O N E N
Ramanathan S, Karupiah S, Nair NK, Olliaro PL, Navaratnam V,
Wernsdorfer WH, Mansor SM 2005. A new and simple solid-phase extraction
method for LC determination of pyronaridine in human plasma. J
Chromatography B 824:45-50
Congpuong K, Na-Bangchang K, Mungthin M, Bualombei P, Wernsdorfer WH 2005.
Molecular epidemiology of drug resistance markers of Plasmodium falciparum
malaria in Thailand. Trop Med Int Health 10: 717-722
Mariga ST, Gil JP, Wernsdorfer WH, Björkman A 2005. Pharmacodynamic
interactions of amodiaquine and its major metabolite desethylamodiaquine
with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro.
Acta Tropica 93: 221-231
Rojanawatsirivet C, Congpuong K, Vijaikadga S, Tongphua S, Thongsri K,
Bangchang KN, Wilairatana P, Wernsdorfer WH 2004. Declining mefloquine
sensitivity of Plasmodium falciparum along the Thai-Myanmar border.
Southeast Asian J Trop Med. Public Health 35: 560-565
Samal D, Rojanawatsirivet, Wernsdorfer G, Kollaritsch H, Sirichaisinthop J,
Wernsdorfer WH 2005. Synergism of desbutyl-benflumetol and retinol against
Plasmodium falciparum in vitro. Wien Klin Wschr 117 (Suppl 4): 39-44
Thriemer K, Wernsdorfer G, Rojanawatsirivet C, Kollaritsch H,
Sirichaisinthop J, Wernsdorfer WH 2005. In vitro activity of artemisinin
alone and in combination with retinol against Plasmodium falciparum. Wien
Klin Wschr 117 (Suppl 4): 45-48
Knauer A, Das AK, Tansuphasawadikul S, Supanaranond W, Pitisuttithum P,
Wernsdorfer WH 2005. Clinical features, aetiology and short-term outcome of
interstitial pneumonitis in HIV/AIDS patients at Bamrasnaradura hospital,
Nonthaburi, Thailand. Wien
Klin Wschr 117 (Suppl 4): 49-55; IP: 0,91
A K T I V I T Ä T E N
Derzeit keine
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