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ARBEITSGRUPPE:
EXPERIMENTELLE
TROPENMEDIZIN UND FELDFORSCHUNG
Leiter: Doz. DDr. Harald
Noedl
A d r e s s e:
Kinderspitalgasse 15, A-1090 Wien
Tel: +43-1-40 160-38220
Fax.: +43-1-40 160-938293
Email: harald.noedl@meduniwien.ac.at
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LEBENSLAUF:
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2006
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Venia docendi an der Med. Univ. Wien im Fach
„Spezifische Prophylaxe und Tropenmedizin“
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2005
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Facharzt „Spezifische Prophylaxe und
Tropenhygiene“
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2002
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Doctor
of Philosophy (Ph.D.), Faculty of Tropical Medicine, Mahidol University,
Bangkok
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2000
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Master
of Clinical Tropical Medicine (M.C.T.M.), Faculty of Tropical Medicine, Mahidol Univ.,
Bangkok
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1999
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Diploma
in Tropical Medicine and Hygiene (D.T.M.&H.), Faculty of Tropical
Medicine, Mahidol University, Bangkok
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1998
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Dr. med univ., Universität Wien
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MITARBEITERINNEN
Wien:
Dr. Markus Fally
Mag. Hans-Peter Führer
Deepa Ganesh, MSc
Verena Hofecker
Mariella Jung
Mag. Julia Matt
Anja Siedl
Dr. Peter Starzengruber
Dr. Paul Swoboda
Matthias Vossen
Bangladesch:
Mun Thawn Bawm
Nayebur Rahman
Ching Sang Thwe
Moung Thing Hla
Thawn Sang Bawm
Al Mamun
Bawdot
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FORSCHUNG:
The Experimental Tropical Medicine and Field Research unit is conducting
randomized clinical trials, laboratory investigations, and epidemiological
studies in Bangladesh, Thailand, and Cambodia,
as well as laboratory-based research and drug development projects in Austria. A
major focus of our research is clinical investigations on a number of
tropical diseases, including malaria, leptospirosis, dengue, influenza, and
typhoid fever.
 The
unit is operating a permanent clinical trials and epidemiology center (MARIB - Malaria Research Initiative Bandarban)
in southeastern Bangladesh and has recently carried out research projects in
collaboration with renowned tropical medicine research institutions in Bangladesh
(International Centre for Diarrhoeal Disease Research, Bangladesh, ICDDR,B;
Chittagong Medical College; Ministry of Health and Family Welfare), Thailand
(USAMC-AFRIMS, Bangkok; Mahidol University, Bangkok; Thamassat University,
Bangkok; Thai Ministry of Public Health, Nonthaburi), Cambodia (National
Center for Parasitology, Entomology and Malaria Control, Cambodia), the US
(WRAIR; Johns Hopkins University), and Europe (WHO).
 Recently
completed clinical investigations include an open label, randomized,
controlled clinical trial comparing the efficacy of a novel artemisinin-based
combination therapy (azithromycin-artesunate) with the current gold standard
(artemether-lumefantrine) for the treatment of uncomplicated falciparum
malaria in Bangladesh.
The study confirms our earlier results suggesting that
azithromycin-artesunate is an extremely well tolerated and highly efficacious
combination therapy for the treatment of falciparum malaria in children and
adults. A randomized controlled clinical trial with artesunate monotherapy,
which was specifically designed to address the question of potential clinical
artemisinin resistance in Southeast Asia,
was finally published in the NEJM in late 2008. The study suggests that
clinically artemisinin resistant P. falciparum malaria has already emerged
and that aggressive surveillance and containment strategies are needed to
limit the impact of resistance to the most important antimalarial drug. A
follow-up clinical trial in collaboration with the WHO assessing the baseline
efficacy of artesunate monotherapy in an area where (unlike Cambodia)
artemisinins have never been used on any significant scale has recently
(autumn 2009) been completed at our site in Bandarban.
 A
large scale cross sectional study with a sample size of >2500 individuals
was designed to assess the prevalence of malaria and selected non-malaria
febrile illnesses in southeastern Bangladesh. Preliminary data
suggest a high prevalence of malaria, typhoid fever, and leptospirosis in the
region. Further investigations are planned to better define the role of these
diseases for the local population. Drug development studies (including target
identification studies, structure-activity relations, and drug interactions)
are being conducted in collaboration with the Institute of Medical
Chemistry with the aim of identifying novel
compounds for the treatment of malaria.
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