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ARBEITSGRUPPE:
VAKZINOLOGIE
UND IMMUNOLOGIE
Leiterin: o. Univ.
Prof. Dr. Ursula Wiedermann-Schmidt, MD, PhD
A d r e s s
e:
Kinderspitalgasse
15, A-1090 Wien
Tel: +43-1-40 490-64890
Fax.: +43-1-40 490-64899
Email: ursula.wiedermann@meduniwien.ac.at
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1990
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Promotion zum Dr. med. an der
Universität Wien
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1990 – 1995
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PhD-Studium am Institut für Klin.
Immunologie Univ. Göteborg, Schweden
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1993
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Master of Science, Univ.
Göteborg, Schweden
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 1995
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Promotion zum Dr. of Philosophy (Phd),
Univ. Göteborg, Schweden
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1999
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Habilitation zum
Universitätsdozenten an der Universität Wien
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2000
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a.o. Prof. und Leiterin d.
Arbeitsgruppe „Mukosale Immunität und Vakzinologie“ an
der Abteilung für Spezifische Prophylaxe und Tropenmedizin
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seit 01/2002
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Facharzt im Sonderfach
„Immunologie“
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seit 01/2004
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Facharzt für „Spezifische
Prophylaxe und Tropenhygiene“
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seit 01/2004
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Mitglied und Co-Leitung des Zentrums
für Reisemedizin der FÄ für Spezifische Prophylaxe und
Tropenmedizin
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seit 10/2004
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Leiterin des Institutes für
Spezif. Prophylaxe und Tropenmedizin am Zentrum für Physiologie,
Pathophysiologie und Immunologie, Med. Univ. Wien
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seit 11/2005
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Bestellung als Mitglied des
Impfausschusses des Obersten Sanitätsrat des Ministerium für
Gesundheit, Familie und Jugend
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seit 10/2006
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Professorin für Vakzinologie der
Med. Univ. Wien
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Wissenschaftliche
Mitarbeiter der Arbeitsgruppe:
Mag. Johnnie Akgün, PhD-student
MsC Erika Garner-Spitzer, Tech.
Mag. Elisabeth Hoflehner, PhD-student
Dipl. Ing. Joanna Jasinska
Dr. Irma
Schabussova
Onisa Ul-Haq
Dr. Angelika Wagner
F O R S C H U N G S P R O J E K T E
Research interests
Animal
models for infectious diseases, allergy and tumorbiology
Mucosal
vaccines for prophylaxis and therapy of allergy, infectious diseases and
cancer (breast cancer, melanoma)
New
antigen delivery systems and adjuvants
Immunological
tolerance as treatment strategy against immunological disorders
Ongoing research programs
Animal models:
Allergy
(mono and polysensitized animals)
Toxoplasma
gondii infection
Breast
cancer and melanoma
Mucosal vaccination and delivery of vaccines:
Lactic acid bacteria as expression systems
and
vaccine vehicles for:
Allergens,
hypoallergenic variants, chimeric molecules
Protozoal
antigens: surface antigen of T. gondii (SAG1)
Tumor
antigens: Her-2/neu peptides, mimotopes of melanoma antigens (HWW)
Mucosal tolerance induction:
Mucosal
tolerance induction as treatment concept
(prophylaxis and
therapy) against allergic
monosensitization:
studies on mechanisms of
tolerance
Tolerance
induction against allergic
polysensitization:
use of hybrid peptides or chimeric
molecules
Development of a peptide based vaccine against
breast cancer: from bench to clinic
Her-2/neu
transgenic mouse model:
Immunization with
peptides derived from extracellular
domain of Her-2/neu
coupled to immunopotentiating
reconstituted
influenza virosomes
Phase I/II
study in humans: cooperation with
Internal Medicine,
MUW, BLS and Pevion Biotech.
Characterization of humoral and cellular immune
responses after vaccination
Evaluation
of antibody titers 10 years after
vaccination with Hep.
A vaccine
Measurement
of cellular immune responses (T cell
proliferation,
cytokine production pattern)
Characterization
of T cell populations (cell surface
marker expression)
HAV-receptor
expression profile (mRNA) on T cells
Newly initiated projects
Toxoplasma gondii infection:
Inverse
correlation between infections such as hepatitis A
or toxoplasmosis and
prevalence of atopy („hygiene
hypothesis“):
Influence of a toxoplasma gondii infection on
allergic
sensitization tested in a mouse model.
Immunological
responses during the course of
infection (Th1 versus
Th2 reponses, Treg cells, cytokine
production profile).
Recombinant bacterial based mucosal vaccine
against T. gondii
Expression
of SAG1, a surface antigen of T. gondii, by lactic acid
bacteria (L.
plantarum) with Th1 promoting properties
Use as an
oral vaccine in a model of T.gondii infection – evaluation
of
immunogenicity and
protection
(Studies in cooperation with Institute Pasteur de
Lille Grant Amadeus A/F
and the Dept. of Pediatrics, Vienna)
Academic activities, lectures and education
Lectures:
Immunization
practice
Infectious
Diseases and Tropical Medicine
Seminar in
„Funktionelle Pathologie“
Repetitorium
in „Funktionelle Pathologie“
Immunological
basics in „Host-Parasite Interactions“ (MCW)
Seminar in
„Vaccinology and Tropical Medicine“ (SSM3, MCW)
Basics in
Immunology (PhD-Program, MCW)
Supervision of diploma and doctor theses:
2 PhD
Students (NMUW), 2 Diploma student (NMUW)
Exams (Rigorosen):
„Funktionelle
Pathologie“ (MUW)
Academic activities, lectures and education
Medical Education in charge
Specific
Prophylaxis and Tropical Medicine (2, 2005)
Immunology
(supervision) (1, 2004)
Consultancy for the Ministry of Health
Member of
the ACIP of the Supreme Board of Health
(e.g. vaccination
schedules; consultance for influenza pandemy strategy
planning)
Invited lectures and international congresses
Invited
lectures: 2004: 6; 2005: 9
Presentations
at international congresses: 2004: 10; 2005: 9
Cooperations
Center for Physiology and Pathophysiology
SPTM
Institute of Pathophysiology (H.
Breiteneder, K.Hoffmann-Sommergruber, R. Valenta)
MUW
Univ. Clinic for Internal Medicine I, Department
of Pediatrics, Univ. Clinic for
Dermatology, Institute of Environmental Medicine,
Department of Surgery
National
Institute of Genetics and Molecular Biology,
University Salzburg
BioLife Science
International
Institute Pasteur de Lille (Lille France)
Nestlé Research Center
(Lausanne, Switzerland)
Pevion Biotech (Bern, Switzerland)
Institute of Clinical Chemistry and Molecular
Diagnostics (Marburg, Germany)
Institute of Immunology and Gnotobiotics, Praque, Czech
Republic
Selected publications
Kozakova,
H., L. A. Hanson, R. Stepankova, H. Kahu, U. I.
Dahlgren, and U.
Wiedermann*.
2003. Vitamin A deficiency leads to severe functional disturbance
of
the intestinal epithelium enzymes associated with diarrhoea and increased
bacterial
translocation in gnotobiotic rats. Microbes
Infect 5:405.
Hafner, C., H. Breiteneder, S. Ferrone, C. Thallinger, S. Wagner, W.
M. Schmidt, J. Jasinska, M. Kundi, K. Wolff, C. C. Zielinski, O. Scheiner,
U. Wiedermann*, and H. Pehamberger. 2005. Suppression of
human melanoma tumor growth in SCID mice by a human high molecular
weight-melanoma associated antigen (HMW-MAA) specific monoclonal antibody. Int J Cancer 114:426.
Hufnagl, K., B. Winkler, M. Focke,
R. Valenta, O. Scheiner, H. Renz, and U.
Wiedermann*. 2005.
Intranasal tolerance induction with polypeptides derived
from
3 noncross-reactive major aeroallergens prevents allergic polysensitization
in
mice. J Allergy Clin Immunol 116:370.
Winkler,
B., K. Hufnagl, A. Spittler, M. Ploder, E. Kallay, S. Vrtala, R. Valenta,
M.
Kundi, H. Renz, and U.
Wiedermann*. 2006. The role of Foxp3+ T cells in long-
term
efficacy of prophylactic and therapeutic mucosal tolerance induction in
mice.
Allergy 61:173.
Daniel,
C., A. Repa, C. Wild, A. Pollak, B. Pot, H. Breiteneder, U. Wiedermann*,
and
Mercenier. 2006. Modulation of allergic immune responses by mucosal
application
of recombinant lactic acid bacteria producing the major birch pollen
allergen Bet v 1. Allergy 61:812.
Wagner, S., J. Jasinska, H.
Breiteneder, M. Kundi, H. Pehamberger, O.
Scheiner, C. Zielinski, and U.
Wiedermann*. 2007. Delayed tumor onset and
reduced
tumor growth progression after immunization with a Her-2/neu multi
peptide
vaccine and IL-12 in c-neu transgenic mice. Breast Cancer Res Treat.
2007
Jan 3; [Epub ahead of print].
Rendi-Wagner, P., M. Korinek, B.
Winkler, M. Kundi, H. Kollaritsch, and U.
Wiedermann*.
2007. Persistence of seroprotection 10 years after primary
hepatitis
A vaccination in an unselected study population. Vaccine 25:927.
Bublin, M., E. Hoflehner, B.
Wagner, C. Radauer, S. Wagner, K. Hufnagl, D.
Allwarth, O. Scheiner, U.
Wiedermann*, H. Breiteneder. 2007. Use of a genetic
cholera
toxin B subunit/allergen-fusion molecule as mucosal delivery system with
immunosuppressive
activity against Th2 immune responses. Vaccine 25: 8395
404.
* corresponding
author
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