Research Group of Johannes A. Schmid

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Scientific Articles:  

67. Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury.

Kral-Pointner JB, Schrottmaier WC, Horvath V, Datler H, Hell L, Ay C, Niederreiter B, Jilma B, Schmid JA, Assinger A, Mackman N, Knapp S, Schabbauer G. J Thromb Haemost. 2017 May 16. doi: 10.1111/jth.13737.

 

66. Novel approach for accurate tissue-based protein colocalization and proximity microscopy. Mirjam I. Lutz, Carmen Schwaiger, Bernhard Hochreiter, Gabor G. Kovacs, Johannes A. Schmid. 2017 Jun 1;7(1):2668. doi: 10.1038/s41598-017-02735-8

 

65. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.

Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2766-E2775. doi: 10.1073/pnas.1618411114. Epub 2017 Mar 14.

 

64. Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.Schwarz T, Prieler B, Schmid JA, Grzmil P, Neesen J.

Eur J Cell Biol. 2017 Feb 20. pii: S0171-9335(16)30178-9. doi: 10.1016/j.ejcb.2017.02.003. [Epub ahead of print]

 

63. Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition.

Kuttke M, Sahin E, Pisoni J, Percig S, Vogel A, Kraemmer D, Hanzl L, Brunner JS, Paar H, Soukup K, Halfmann A, Dohnal AM, Steiner CW, Blüml S, Basilio J, Hochreiter B, Salzmann M, Hoesel B, Lametschwandtner G, Eferl R, Schmid JA, Schabbauer G.

Oncoimmunology. 2016 Mar 28;5(7):e1164918. doi: 10.1080/2162402X.2016.1164918. eCollection 2016 Jul.

 

62. Fluorescence colocalization microscopy analysis can be improved by combining object-recognition with pixel-intensity-correlation.

Moser B, Hochreiter B, Herbst R, Schmid JA.

Biotechnol J. 2017 Jan;12(1). doi: 10.1002/biot.201600332. Epub 2016 Jul 26.

 

61. Endoplasmosis and exoplasmosis: the evolutionary principles underlying endocytosis, exocytosis, and vesicular transport.

Schmid JA.

Wien Med Wochenschr. 2016 May;166(7-8):236-41. doi: 10.1007/s10354-016-0453-2.

 

60. Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.

Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P.

J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30.

 

59. Sequence-function correlations and dynamics of ERG isoforms. ERG8 is the black sheep of the family.

Hoesel B, Malkani N, Hochreiter B, Basílio J, Sughra K, Ilyas M, Schmid JA.

Biochim Biophys Acta. 2016 Feb;1863(2):205-18. doi: 10.1016/j.bbamcr.2015.10.023. Epub 2015 Nov 10.

 

58. Fluorescent proteins as genetically encoded FRET biosensors in life sciences.

Hochreiter B, Garcia AP, Schmid JA.

Sensors (Basel). 2015 Oct 16;15(10):26281-314. doi: 10.3390/s151026281. Review.

 

57. Alpha-catulin contributes to drug-resistance of melanoma by activating NF-κB and AP-1.

Kreiseder B, Holper-Schichl YM, Muellauer B, Jacobi N, Pretsch A, Schmid JA, de Martin R, Hundsberger H, Eger A, Wiesner C.

PLoS One. 2015 Mar 20;10(3):e0119402. doi: 10.1371/journal.pone.0119402. eCollection 2015.

 

56. Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.

Kunze M, Malkani N, Maurer-Stroh S, Wiesinger C, Schmid JA, Berger J.

J Biol Chem. 2015 Feb 20;290(8):4928-40. doi: 10.1074/jbc.M114.601575. Epub 2014 Dec 23.

 

55. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.

Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, Saliba A, Eckerstorfer P, Britzen-Laurent N, Schütz G, Schmid JA, Zlabinger GJ, Naschberger E, Stürzl M, Stockinger H.

J Immunol. 2014 Jan 15;192(2):771-81. doi: 10.4049/jimmunol.1300377. Epub 2013 Dec 13.

 

54. The complexity of NF-κB signaling in inflammation and cancer.

Hoesel B, Schmid JA.

Mol Cancer. 2013 Aug 2;12:86. doi: 10.1186/1476-4598-12-86. Review.

 

53. Endothelial CSN5 impairs NF-κB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions.

Asare Y, Shagdarsuren E, Schmid JA, Tilstam PV, Grommes J, El Bounkari O, Schütz AK, Weber C, de Winther MP, Noels H, Bernhagen J.

Thromb Haemost. 2013 Jul;110(1):141-52. doi: 10.1160/TH13-02-0155. Epub 2013 May 2.

 

52. Endosomal trafficking of the receptor tyrosine kinase MuSK proceeds via clathrin-dependent pathways, Arf6 and actin.

Luiskandl S, Woller B, Schlauf M, Schmid JA, Herbst R.

FEBS J. 2013 Jul;280(14):3281-97. doi: 10.1111/febs.12309. Epub 2013 May 23.

 

51. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.

Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, Knapp B, Haas R, Schmid JA, Jandl C, Amir S, Lubec G, Park J, Esterbauer H, Bilban M, Brizuela L, Pospisilik JA, Otterbein LE, Wagner O.

Cell Metab. 2012 Jun 6;15(6):813-26. doi: 10.1016/j.cmet.2012.04.023.

 

50. Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation.

Ginter T, Bier C, Knauer SK, Sughra K, Hildebrand D, Münz T, Liebe T, Heller R, Henke A, Stauber RH, Reichardt W, Schmid JA, Kubatzky KF, Heinzel T, Krämer OH.

Cell Signal. 2012 Jul;24(7):1453-60. doi: 10.1016/j.cellsig.2012.02.018. Epub 2012 Mar 7.

 

49. Combining in vivo reflectance with fluorescence confocal microscopy provides additive information on skin morphology.

Skvara H, Plut U, Schmid JA, Jonak C.

Dermatol Pract Concept. 2012 Jan 31;2(1):3-12. doi: 10.5826/dpc.0201a02.. eCollection 2012 Jan.

 

48. Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7.

Kunze M, Neuberger G, Maurer-Stroh S, Ma J, Eck T, Braverman N, Schmid JA, Eisenhaber F, Berger J.

J Biol Chem. 2011 Dec 30;286(52):45048-62. doi: 10.1074/jbc.M111.301853. Epub 2011 Nov 5.

 

47. In vivo fluorescence confocal microscopy: indocyanine green enhances the contrast of epidermal and dermal structures.

Skvara H, Kittler H, Schmid JA, Plut U, Jonak C.

J Biomed Opt. 2011 Sep;16(9):096010. doi: 10.1117/1.3625255.

 

46. Intradermal indocyanine green for in vivo fluorescence laser scanning microscopy of human skin: a pilot study.

Jonak C, Skvara H, Kunstfeld R, Trautinger F, Schmid JA.

PLoS One. 2011;6(8):e23972. doi: 10.1371/journal.pone.0023972. Epub 2011 Aug 31.

 

45. Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model.

Birbach A, Eisenbarth D, Kozakowski N, Ladenhauf E, Schmidt-Supprian M, Schmid JA.

Neoplasia. 2011 Aug;13(8):692-703.

 

44. Some secrets of fluorescent proteins: distinct bleaching in various mounting fluids and photoactivation of cyan fluorescent proteins at YFP-excitation.

Malkani N, Schmid JA.

PLoS One. 2011 Apr 7;6(4):e18586. doi: 10.1371/journal.pone.0018586.

 

43. Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling.

Sughra K, Birbach A, de Martin R, Schmid JA.

PLoS One. 2010 Sep 13;5(9):e12683. doi: 10.1371/journal.pone.0012683.

 

42. Functional remodeling of benign human prostatic tissues in vivo by spontaneously immortalized progenitor and intermediate cells.

Jiang M, Strand DW, Fernandez S, He Y, Yi Y, Birbach A, Qiu Q, Schmid J, Tang DG, Hayward SW.

Stem Cells. 2010 Feb;28(2):344-56. doi: 10.1002/stem.284.

 

41. A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate.

Birbach A, Casanova E, Schmid JA.

Genesis. 2009 Nov;47(11):757-64. doi: 10.1002/dvg.20558.

 

40. Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome.

Orel L, Neumeier H, Hochrainer K, Binder BR, Schmid JA.

J Cell Mol Med. 2010 Jun;14(6B):1555-68. doi: 10.1111/j.1582-4934.2009.00866.x. Epub 2009 Jul 28.

 

39. Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance.

Zebedin E, Simma O, Schuster C, Putz EM, Fajmann S, Warsch W, Eckelhart E, Stoiber D, Weisz E, Schmid JA, Pickl WF, Baumgartner C, Valent P, Piekorz RP, Freissmuth M, Sexl V.

Blood. 2008 Dec 1;112(12):4655-64. doi: 10.1182/blood-2008-02-139105. Epub 2008 Aug 6.

 

38. Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies.

Korkhov VM, Milan-Lobo L, Zuber B, Farhan H, Schmid JA, Freissmuth M, Sitte HH.

J Mol Biol. 2008 Apr 25;378(2):337-52. doi: 10.1016/j.jmb.2008.02.056. Epub 2008 Mar 4.

 

37. IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB.

Schmid JABirbach A.

Cytokine Growth Factor Rev. 2008 Apr;19(2):157-65. doi: 10.1016/j.cytogfr.2008.01.006. Epub 2008 Mar 4. Review.

 

36. Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis.

Wiesner C, Winsauer G, Resch U, Hoeth M, Schmid JA, van Hengel J, van Roy F, Binder BR, de Martin R.

Oncogene. 2008 Apr 3;27(15):2159-69. Epub 2007 Oct 22.

 

35. Fluorescent proteins and fluorescence resonance energy transfer (FRET) as tools in signaling research.

Schmid JABirbach A.

Thromb Haemost. 2007 Mar;97(3):378-84. Review.

 

34. Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D.

Farhan H, Reiterer V, Korkhov VM, Schmid JA, Freissmuth M, Sitte HH.

J Biol Chem. 2007 Mar 9;282(10):7679-89. Epub 2007 Jan 8.

 

33. Selective inhibitors of vitamin D metabolism--new concepts and perspectives.

Schuster I, Egger H, Herzig G, Reddy GS, Schmid JA, Schüssler M, Vorisek G.

Anticancer Res. 2006 Jul-Aug;26(4A):2653-68. Review.

 

32. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways.

Yang J, Amiri KI, Burke JR, Schmid JA, Richmond A.

Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):950-60.

 

31. Evolutions in science triggered by green fluorescent protein (GFP).

Schmid JA, Neumeier H.

Chembiochem. 2005 Jul;6(7):1149-56. Review. No abstract available.

 

30. Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome.

Löscher M, Fortschegger K, Ritter G, Wostry M, Voglauer R, Schmid JA, Watters S, Rivett AJ, Ajuh P, Lamond AI, Katinger H, Grillari J.

Biochem J. 2005 Jun 1;388(Pt 2):593-603.

 

29. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53.

Hofer-Warbinek R, Schmid JA, Mayer H, Winsauer G, Orel L, Mueller B, Wiesner Ch, Binder BR, de Martin R.

Cell Death Differ. 2004 Dec;11(12):1317-25.

 

28. Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK.

Birbach A, Bailey ST, Ghosh S, Schmid JA.

J Cell Sci. 2004 Jul 15;117(Pt 16):3615-24.

 

27. Application of spectral imaging microscopy in cytomics and fluorescence resonance energy transfer (FRET) analysis.

Ecker RC, de Martin R, Steiner GE, Schmid JA.

Cytometry A. 2004 Jun;59(2):172-81.

 

26. Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporter.

Just H, Sitte HH, Schmid JA, Freissmuth M, Kudlacek O.

J Biol Chem. 2004 Feb 20;279(8):6650-7. Epub 2003 Dec 5.

 

25. Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein.

Spahn L, Siligan C, Bachmaier R, Schmid JA, Aryee DN, Kovar H.

Oncogene. 2003 Oct 9;22(44):6819-29.

 

24. Cover the eyes of Lady Justice.

Schmid JA.

EMBO Rep. 2003 Aug;4(8):734-6. No abstract available.

 

23. Genomics and proteomics in cancer.

Baak JP, Path FR, Hermsen MA, Meijer G, Schmidt J, Janssen EA.

Eur J Cancer. 2003 Jun;39(9):1199-215. Review.

 

22. Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation.

Henkler F, Baumann B, Fotin-Mleczek M, Weingärtner M, Schwenzer R, Peters N, Graness A, Wirth T, Scheurich P, Schmid JA, Wajant H.

J Biol Chem. 2003 Aug 1;278(31):29216-30. Epub 2003 Apr 22.

 

21. GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta.

Ebner K, Bandion A, Binder BR, de Martin R, Schmid JA.

Blood. 2003 Jul 1;102(1):192-9. Epub 2003 Mar 13.

 

20. Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNF alpha -induced PAI-1 expression.

Gruber F, Hufnagl P, Hofer-Warbinek R, Schmid JA, Breuss JM, Huber-Beckmann R, Lucerna M, Papac N, Harant H, Lindley I, de Martin R, Binder BR.

Blood. 2003 Apr 15;101(8):3042-8. Epub 2002 Dec 27.

 

19. Fluorescence resonance energy transfer in the study of cancer pathways.

Schmid JA, Sitte HH.

Curr Opin Oncol. 2003 Jan;15(1):55-64. Review.

 

18. Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway.

Spahn L, Petermann R, Siligan C, Schmid JA, Aryee DN, Kovar H.

Cancer Res. 2002 Aug 15;62(16):4583-7.

 

17. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8.

Fotin-Mleczek M, Henkler F, Samel D, Reichwein M, Hausser A, Parmryd I, Scheurich P, Schmid JA, Wajant H.

J Cell Sci. 2002 Jul 1;115(Pt 13):2757-70.

 

16. Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus.

Birbach A, Gold P, Binder BR, Hofer E, de Martin R, Schmid JA.

J Biol Chem. 2002 Mar 29;277(13):10842-51. Epub 2002 Jan 18.

 

15. Impact of oligomerization on the function of the human serotonin transporter.

Schmid JA, Just H, Sitte HH.

Biochem Soc Trans. 2001 Nov;29(Pt 6):732-6. Review.

 

14. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.

Piddini E, Schmid JA, de Martin R, Dotti CG.

EMBO J. 2001 Aug 1;20(15):4076-87.

 

13. Adenovirus-mediated expression of a mutant IkappaB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli.

Oitzinger W, Hofer-Warbinek R, Schmid JA, Koshelnick Y, Binder BR, de Martin R.

Blood. 2001 Mar 15;97(6):1611-7.

 

12. The transcription factor NF-kappa B and the regulation of vascular cell function.

De Martin R, Hoeth M, Hofer-Warbinek R, Schmid JA.

Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):E83-8. Review.

 

11. Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

Schmid JA, Scholze P, Kudlacek O, Freissmuth M, Singer EA, Sitte HH.

J Biol Chem. 2001 Feb 9;276(6):3805-10. Epub 2000 Nov 8.

 

10. Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.

Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R.

J Biol Chem. 2000 Jul 21;275(29):22064-8.

 

9. Dynamics of NF kappa B and Ikappa Balpha studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNa by fluorescence resonance energy transfer.

Schmid JABirbach A, Hofer-Warbinek R, Pengg M, Burner U, Furtmüller PG, Binder BR, de Martin R.

J Biol Chem. 2000 Jun 2;275(22):17035-42.

 

8. The NF-kappaB/Rel family of transcription factors in oncogenic transformation and apoptosis.

de Martin R, Schmid JA, Hofer-Warbinek R.

Mutat Res. 1999 Nov;437(3):231-43. Review.

 

7. Accumulation of sialic acid in endocytic compartments interferes with the formation of mature lysosomes. Impaired proteolytic processing of cathepsin B in fibroblasts of patients with lysosomal sialic acid storage disease.

Schmid JA, Mach L, Paschke E, Glössl J.

J Biol Chem. 1999 Jul 2;274(27):19063-71.

 

6. Localization of the human I-kappaB kinase-beta (IKBKB) to chromosome 8p11.2 by fluorescence in situ hybridization and radiation hybrid mapping.

Ambros PFSchmid J, Rumpler S, Binder BR, de Martin R.

Genomics. 1998 Dec 15;54(3):575-6. No abstract available.

 

5. In vitro fusion of tissue-derived endosomes and lysosomes.

Schmid JA, Ellinger I, Kosma P.

Eur J Cell Biol. 1998 Nov;77(3):166-74.

 

4. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J.

J Exp Med. 1998 Jul 6;188(1):211-6.

 

3. Simple method for high sensitivity chemiluminescence ELISA using conventional laboratory equipment.

Schmid JA, Billich A.

Biotechniques. 1997 Feb;22(2):278-80. No abstract available.

 

2. The acidic environment in endocytic compartments.

Schmid JA.

Biochem J. 1994 Oct 15;303 ( Pt 2):679-80. No abstract available.

 

1.Endosome maturation: insights from somatic cell genetics and cell-free analysis.

Murphy RFSchmid J, Fuchs R.

Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):716-20. Review. No abstract available.

 

Book Reviews


- ChemBioChem
(2009), Vol. 17, 2801-2802: Review on: Viral Applications of Green Fluorescent Protein, Methods and Protocols; Methods in Molecular Biology, Vol. 515

Monographs

  1. J. A. Schmid: Diplomarbeit (1990): Veränderte Prozessierung von Kathepsin B in Fibroblasten von Patienten mit Sialinsäure-Speicherkrankheit.

  2. J. A. Schmid: Dissertation (1994): Endocytose und Transcytose in Hepatocyten

Online Report for the European Advanced Light Microscopy Facility

Chapters in textbooks

J. A. Schmid, H. Klapper and R. Fuchs: Characterization of basolateral and apical endocytic pathways in rat hepatocytes. In: Hepatic Endocytosis of Lipids and Proteins, ed. by: E. Windler and H. Greten, p. 31-36, W. Zuckerschwerdt Verlag 1992. 

 

Johannes A. Schmid