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About Us: Robert Loewe, M.D.

Robert Loewe
Robert Loewe, M.D. Associate Professor Principal Investigator Phone: +43-1-40400-73716  Fax: +43-1-5851897 20 E-mail:

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Curriculum Vitae

Present position

Senior Physician/Consultant, Department of Dermatology, Medical University Vienna
Clinical responsibility: Dermatopatholgy, Clinic for rare skin cancers, outpatient service
Principal Investigator at the Skin and Endothelium Research Division (SERD)

Current Project/s

  • Epidermal growth factor facilitates melanoma lymph node metastasis by influencing tumor lymphangiogenesis
  • Identification of a chemokine expression signature associated with prometastatic properties in cutaneous melanoma

Education

2010 Senior Medical Consultant Al Ain Hospital, Al Ain, Abu Dhabi, VAE
2008 Senior physician, Department of Dermatology, Medical University of Vienna
11/2007 venia docendi for Dermatology (Associate Professor with tenure)
2007 Visiting fellow at the Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Since 2005 Group Leader and Biomedical Scientist at the Skin and Endothelium Research Division, Medical University of Vienna, Vienna, Austria
Department of Dermatology (Prof. Dr. Peter Petzelbauer)
2006 Board certification for Dermatology
2001 - 2006 Residency training in Dermatology, Division of General Dermatology, Medical University of Vienna, Vienna, Austria (Chairman: Prof. Dr. Klaus Wolff, Prof. Dr. Hubert Pehamberger)
Specialist training in Dermatopathology
1999 - 2001 Postdoctoral Fellow at the Skin and Endothelium Laboratory at the Department of Dermatology (Head Prof. Klaus Wolff), Division of General Dermatology at the Medical University of Vienna
1998 - 1999 Internship at the Second Internal Department (Cardiology and Critical Care Unit) at the General Hospital, Wels, Austria (Head Prim. Prof. Bernd Eber)
1986 - 1996 University of Vienna Medical School, Vienna, Austria
Graduation May 1996

Publications

  1. Bracher A, Cardona AS, Tauber S, Fink AM, Steiner A, Pehamberger H, Niederleithner H, Petzelbauer P, Gröger M, Loewe R. Epidermal Growth Factor Facilitates Melanoma Lymph Node Metastasis by Influencing Tumor Lymphangiogenesis. J Invest Dermatol. 2013 Jan;133(1):230-8. Epub 2012 Sep 6.
  2. Wnt1 Is Anti-Lymphangiogenic in a Melanoma Mouse Model. Niederleithner H, Heinz M, Tauber S, Bilban M, Pehamberger H, Sonderegger S, Knöfler M, Bracher A, Berger W, Loewe R, Petzelbauer P.J Invest Dermatol. 2012 May [Epub ahead of print]
  3. P53 mutation is a rare event in Merkel cell carcinoma of the head and neck. Lill C, Schneider S, Item CB, Loewe R, Houben R, Halbauer D, Heiduschka G, Brunner M, Thurnher D.Eur Arch Otorhinolaryngol. 2011 Nov;268(11):1639-46.
  4. Soluble M6P/IGF2R Released by TACE Controls Angiogenesis via Blocking Plasminogen Activation. Leksa V, Loewe R, Binder B, Schiller HB, Eckerstorfer P, Forster F, Cardona AS, Ondrovicová G, Kutejová E, Steinhuber E, Breuss J, Drach J, Petzelbauer P, Binder BR, Stockinger H. Circ. Res. 2011, 108(6):676-85
  5. Magnetic resonance microimaging of human skin vasculature in vivo at 3 Tesla. Laistler E, Loewe R, Moser E.Magn Reson Med. 2011 Jan 19. doi: 10.1002/mrm.22743. [Epub ahead of print]
  6. Significant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients. Lill C, Schneider S, Pammer J, Loewe R, Gedlicka W, Houben R, Heiduschka G, Brunner M, Thurnher D.Head Neck. 2010 Nov 29. [Epub ahead of print]
  7. Malignant Syphilis in a HIV Infected Patient.Jalili A, Mosleh M, Grabmeier-Pfistershammer K, Loewe R, Stingl G, Rieger A.Sex Transm Dis. 2010 Aug 19. [Epub ahead of print]
  8. Stem cell marker upregulation in normal cutaneous vessels following pulsed-dye laser exposure and its abrogation by concurrent rapamycin administration: implications for treatment of port-wine stain birthmarks.Loewe R, Oble DA, Valero T, Zukerberg L, Mihm MC Jr, Nelson JS.J Cutan Pathol. 2010 Apr;37 Suppl 1:76-82.
  9. Combination of dacarbazine and dimethylfumarate efficiently reduces melanoma lymph node metastasis.Valero T, Steele S, Neumüller K, Bracher A, Niederleithner H, Pehamberger H, Petzelbauer P, Loewe R. J Invest Dermatol. 2010 Apr;130(4):1087-94
  10. Erlotinib and Bevacizumab have Synergistic Activity against Melanoma
    N. Schicher , V. Paulitschke , A. Swoboda , R. Kunstfeld , R. Loewe , P. Pilarski, H. Pehamberger, C. Hoeller
    Clin Cancer Res 2009 May 15;15(10):3495-502
  11. Focus on Melanoma TILs: Prognostic Significance and Immunobiology of Tumor Infiltrating Lymphocytes in the Age of Biological Therapy
    DA. Oble, R. Loewe, P. Yu, MC. Mihm, Jr
    Cancer Immunity, 2009, Apr 2;9:3
  12. Janeway Lesions may present with inconspicuous histological features
    Loewe R, Gattringer KB, Petzelbauer P. J Cut Pathol, 2009.Oct;36(10):1095-8.
  13. Dimethylfumarate impairs melanoma growth and metastasis
    R. Loewe, T. Valero, S. Kremling, B. Pratscher, R. Kunstfeld, H. Pehamberger, P. Petzelbauer Cancer Res, 2006 Dec15;66(24)
  14. Empact Syndrome
    S. Woehrl, R. Loewe, W. F. Pickl, G. Stingl, S. N. Wagner J Dtsch Dermatol Ges, 2006 Jan;3(1):39-43
  15. Degos disease with an inconspicuous clinical course
    R. Loewe, M. Palatin, P. Petzelbauer J Eur Acad Dermatol, 2005 Jul;19(4):477-80
  16. The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells
    C. Hoeller, C. Thallinger, B. Pratscher, MD. Bister, N. Schicher, R. Loewe, E. Heere-Ress, F. Roka, V. Sexl, H. Pehamberger J Invest Dermatol, 2005 Jun;124(6):1293-9
  17. IL-3 Induces Expression of Lymphatic Markers Prox-1 and Podoplanin in Human Endothelial Cells
    M. Gröger, R. Loewe, W. Holnthoner, R. Embacher, M. Pillinger, G. S. Herron, K. Wolff, P. Petzelbauer J Immunol, 2004; 173: 7161-7169
  18. BRAF kinase gene V599E mutation in growing melanocytic lesions
    R. Loewe, H. Kittler, G. Fischer, I. Faé, K. Wolff, P. Petzelbauer J Invest Dermatol, 2004 Oct;123:733-736
  19. Apomorphine hyperpigmentation
    R. Loewe, M. Püspök-Schwarz, P. Petzelbauer Hautarzt, 2003 Jan;54(1): 58-63
  20. Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells
    R. Loewe, W. Holnthoner, M. Gröger, M. Pillinger, F. Gruber, D. Mechtcheriakova, E. Hofer, K. Wolff, P. Petzelbauer J Immunol, 2002 May 1;168(9): 4781-7
  21. Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NF-kappa B-dependent manner
    R. Loewe, M. Pillinger, R. de Martin, U. Mrowietz, M. Gröger, W. Holnthoner, K. Wolff, W. Wiegrebe, D. Jirovsky, P. Petzelbauer J Invest Dermatol, 2001 Dec;117(6): 1363-8
  22. Effect of trephination technique on the ultrastructure of corneal transplants: guided trephine system v posterior punch technique
    W. Radner; C. Skorpik; R. Loewe; C. Mudrich; G. Radner; R. Mallinger Br J Ophthalmol, 1999; 83: 1172 1177
  23. Efficacy of Thrombolytic Therapy in Pulmonary Embolism can be determined by Contrast Enhanced MR-Angiography
    H. Frank, R. Loewe, Ch. Loewe, G. Oberhuber, K. Huber, B. Schwaighofer, R. Weissleder Invest Radiol, 1998; 33: 853 - 857
  24. Darstellung und Differenzierung atherosklerotischer Plaques mittels Magnetresonanz
    Ch. Loewe, G. Oberhuber, R. Loewe, H. Frank Z Kardiol, 1998; 87: 622 - 629

Book chapters

  1. Petzelbauer P, Gröger M, Loewe R, Kunstfeld R. 2007. Endothelium and skin. In: Aird, Ed. Endothelial Biomedicine. Cambridge U Press, p1431-1443
  2. Petzelbauer P, Loewe R. 2008. Dimethylfumarate and Cancer. In: Schwab, Ed. Encyclopedia of Cancer, 2nd edition, p871-3
  3. Ebner B., Laßnig E., Singer C., Ablinger O., Höller E., Loewe R., Ratzenböck M., Spitaler E., Steiner P. 2001. Der kleine Notfall, Ein Kompendium für Turnusärzte

Awards

  1. Kardinal Innitzer Förderungspreis of the Archbishop of Vienna, 2008
  2. Award of the Chamber of Commerce Vienna, Austria, 2007
  3. Researcher of the Month, April 2007; Medical University of Vienna, Austria
  4. Klaus Wolff Fellowship, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2007
  5. Scientific award for "innovative and interdisciplinary cancer research" by the mayor of the City of Vienna, Austria, 2004
  6. Scientific award ("AESCA-Preis") for oustanding clinical research by AESCA Austria, 2004
  7. Kyrle fellowship of the Austrian Society for Dermatology and Venerology (ÖGDV), 2002
  8. Excellence Scholarship of the University of Vienna, Austria, 1996

Patents

  1. Fumaric acid derivatives as NF-kappaB inhibitors. Publication info: NZ525148 - 2006-06-30 6

Financial support

Nationalbank/Jubiläumsfonds

2009-2011 Identification of a chemokine expression signature associated with melanoma progression (ONB 13672)
2006-208 Fumarates as NF-kB inhibitors. A new strategy for the therapy of cutaneous melanoma(ONB 11912)

Others

2010 Becas Argo Global Funding, FICYT, Oviedo, E; for ASC
2007 Awawrd of the Chamber of Commerce Vienna, Austria
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Contact Information