WR lab

complete list of publications

Uzonyi, A., D. Dierks, R. Nir, O. S. Kwon, U. Toth, I. Barbosa, C. Burel, A. Brandis, W. Rossmanith, H. Le Hir, B. Slobodin, and S. Schwartz (2023). Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability. Mol. Cell 83, 237-51.
Hochberg, I., L. A. M. Demain, J. Richer, K. Thompson, J. E. Urquhart, A. Rea, W. Pagarkar, A. Rodríguez-Palmero, A. Schlüter, E. Verdura, A. Pujol, P. Quijada-Fraile, A. Amberger, A. J. Deutschmann, S. Demetz, M. Gillespie, I. A. Belyantseva, H. J. McMillan, M. Barzik, G. M. Beaman, R. Motha, K. Y. Ng, J. O'Sullivan, S. G. Williams, S. S. Bhaskar, I. R. Lawrence, E. M. Jenkinson, J. L. Zambonin, Z. Blumenfeld, S. Yalonetsky, S. Oerum, W. Rossmanith, C. Genomics England Research, W. W. Yue, J. Zschocke, K. J. Munro, B. J. Battersby, T. B. Friedman, R. W. Taylor, R. T. O'Keefe, and W. G. Newman (2021). Bi-allelic variants in the mitochondrial RNase P subunit PRORP cause mitochondrial tRNA processing defects and pleiotropic multisystem presentations. Am. J. Hum. Genet. 108, 2195-204.
Schencking, I., W. Rossmanith, and R. K. Hartmann (2020). Diversity and evolution of RNase P. In: Evolutionary Biology—A Transdisciplinary Approach. P. Pontarotti, ed. (Springer, Switzerland). pp. 255-99.
Summer, S., A. Smirnova, A. Gabriele, U. Toth, A. M. Fasemore, K. U. Förstner, L. Kuhn, J. Chicher, P. Hammann, G. Mitulović, N. Entelis, I. Tarassov, W. Rossmanith, and A. Smirnov (2020). YBEY is an essential biogenesis factor for mitochondrial ribosomes. Nucleic Acids Res. 48, 9762-86.
Vilardo, E., F. Amman, U. Toth, A. Kotter, M. Helm, and W. Rossmanith (2020). Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B. Nucleic Acids Res. 48, 6157-69.
Garcia-Campos, M. A., S. Edelheit, U. Toth, M. Safra, R. Shachar, S. Viukov, R. Winkler, R. Nir, L. Lasman, A. Brandis, J. H. Hanna, W. Rossmanith, and S. Schwartz (2019). Deciphering the "m⁶A code" via antibody-independent quantitative profiling. Cell 178, 731-47.
Vilardo, E., C. Nachbagauer, A. Buzet, A. Taschner, J. Holzmann, and W. Rossmanith (2018). Corrigendum to: A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase–extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res. 46, 11126-7.
Jantsch, M. F., A. Quattrone, M. O'Connell, M. Helm, M. Frye, M. Macias-Gonzales, M. Ohman, S. Ameres, L. Willems, F. Fuks, A. Oulas, S. Vanacova, H. Nielsen, C. Bousquet-Antonelli, Y. Motorin, J.-Y. Roignant, N. Balatsos, A. Dinnyes, P. Baranov, V. Kelly, A. Lamm, G. Rechavi, M. Pelizzola, J. Liepins, I. Holodnuka Kholodnyuk, V. Zammit, D. Ayers, F. Drablos, J. A. Dahl, J. Bujnicki, C. Jeronimo, R. Almeida, M. Neagu, M. Costache, J. Bankovic, B. Banovic, J. Kyselovic, L. M. Valor, S. Selbert, P. Pir, T. Demircan, V. Cowling, M. Schäfer, W. Rossmanith, D. Lafontaine, A. David, C. Carre, F. Lyko, R. Schaffrath, S. Schwartz, A. Verdel, A. Klungland, E. Purta, G. Timotijevic, F. Cardona, A. Davalos, E. Ballana, O. C. D, J. Ule, and R. Fray (2018). Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA Biol. 15, 829-31.
Safra, M., A. Sas-Chen, R. Nir, R. Winkler, A. Nachshon, D. Bar-Yaacov, M. Erlacher, W. Rossmanith, N. Stern-Ginossar, and S. Schwartz (2017). The m¹A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature, 551, 251-5.
Nickel, A. I., N. B. Wäber, M. Gößringer, M. Lechner, U. Linne, U. Toth, W. Rossmanith, and R. K. Hartmann (2017). Minimal and RNA-free RNase P in Aquifex aeolicus. Proc. Natl. Acad. Sci. USA 114, 11121-6.
Gößringer, M., M. Lechner, N. Brillante, C. Weber, W. Rossmanith, and R. K. Hartmann (2017). Protein-only RNase P function in Escherichia coli: viability, processing defects and differences between PRORP isoenzymes. Nucleic Acids Res. 45, 7441-54.
Rammelt, C., and W. Rossmanith (2016). Repairing tRNA termini: News from the 3' end. RNA Biol. 13, 1182-8.
Walczyk, D., M. Gößringer, W. Rossmanith, T. S. Zatsepin, T. S. Oretskaya, and R. K. Hartmann (2016). Analysis of the Cleavage Mechanism by Protein-Only RNase P Using Precursor tRNA Substrates with Modifications at the Cleavage Site. J. Mol. Biol. 428, 4917-28.
Brillante, N., M. Gößringer, D. Lindenhofer, U. Toth, W. Rossmanith, and R. K. Hartmann (2016). Substrate recognition and cleavage-site selection by a single-subunit protein-only RNase P. Nucleic Acids Res. 44, 2323-36.
Falk, M. J., X. Gai, M. Shigematsu, E. Vilardo, R. Takase, E. McCormick, T. Christian, E. Place, E. A. Pierce, M. Consugar, H. B. Gamper, W. Rossmanith, and Y.-M. Hou (2016). A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression. RNA Biol. 13, 477-85.
Lechner, M., W. Rossmanith, R. K. Hartmann, C. Thölken, B. Gutmann, P. Giegé, and A. Gobert (2015). Distribution of ribonucleoprotein and protein-only RNase P in Eukarya. Mol. Biol. Evol. 32, 3186-93.
Fiedler, M., W. Rossmanith, E. Wahle, and C. Rammelt (2015). Mitochondrial poly(A) polymerase is involved in tRNA repair. Nucleic Acids Res. 43, 9937-49.
Vilardo, E., and W. Rossmanith (2015). Corrigendum to: Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex. Nucleic Acids Res. 43, 6649.
Vilardo, E., and W. Rossmanith (2015). Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex. Nucleic Acids Res. 43, 5112-9.
Weber, C., A. Hartig, R. K. Hartmann, and W. Rossmanith (2014). Playing RNase P evolution: swapping the RNA catalyst for a protein reveals functional uniformity of highly divergent enzyme forms. PLoS Genet. 10, e1004506.
Vilardo, E., and W. Rossmanith (2013). The amyloid-β-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P. PLoS ONE 8, e65609.
Vilardo, E., C. Nachbagauer, A. Buzet, A. Taschner, J. Holzmann, and W. Rossmanith (2012). A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase–extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res. 40, 11583-93.
Taschner, A., C. Weber, A. Buzet, R. K. Hartmann, A. Hartig, and W. Rossmanith (2012). Nuclear RNase P of Trypanosoma brucei: a single protein in place of the multi-component RNA-protein complex. Cell Rep. 2, 19-25.
Rossmanith, W. (2012). Of P and Z: mitochondrial tRNA processing enzymes. Biochim. Biophys. Acta 1819, 1017-26.
Pavlova, L. V., M. Gößringer, C. Weber, A. Buzet, W. Rossmanith, and R. K. Hartmann (2012). tRNA processing by protein-only versus RNA-based RNase P: kinetic analysis reveals mechanistic differences. ChemBioChem 13, 2270-6.
Wang, S., R. Li, A. Fettermann, Z. Li, Y. Qian, Y. Liu, X. Wang, A. Zhou, J. Q. Mo, L. Yang, P. Jiang, A. Taschner, W. Rossmanith, and M. X. Guan (2011). Maternally inherited essential hypertension is associated with the novel 4263A>G mutation in the mitochondrial tRNA^Ile gene in a large Han Chinese family. Circ. Res. 108, 862-70.
Rossmanith, W. (2011). Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation. PLoS ONE 6, e19152.
Gobert, A., B. Gutmann, A. Taschner, M. Gößringer, J. Holzmann, R. K. Hartmann, W. Rossmanith, and P. Giegé (2010). A single Arabidopsis organellar protein has RNase P activity. Nat. Struct. Mol. Biol. 17, 740-4.
Holzmann, J., and W. Rossmanith (2009). tRNA recognition, processing, and disease: hypotheses around an unorthodox type of RNase P in human mitochondria. Mitochondrion 9, 284-8.
Rossmanith, W., and J. Holzmann (2009). Processing mitochondrial (t)RNAs: new enzyme, old job. Cell Cycle 8, 1650-3.
Holzmann, J., P. Frank, E. Löffler, K. L. Bennett, C. Gerner, and W. Rossmanith (2008). RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell 135, 462-74.
Rossmanith, W., M. Freilinger, J. Roka, T. Raffelsberger, K. Moser-Thier, D. Prayer, G. Bernert, and R. E. Bittner (2008). Isolated cytochrome c oxidase deficiency as a cause of MELAS. J. Med. Genet. 45, 117-21.
Huber, W. W., W. Rossmanith, M. Grusch, E. Haslinger, S. Prustomersky, B. Peter-Vörösmarty, W. Parzefall, G. Scharf, and R. Schulte-Hermann (2008). Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. Food Chem. Toxicol. 46, 1230-8.
Oezen, I., W. Rossmanith, S. Forss-Petter, S. Kemp, T. Voigtlander, K. Moser-Thier, R. J. Wanders, R. E. Bittner, and J. Berger (2005). Accumulation of very long-chain fatty acids does not affect mitochondrial function in adrenoleukodystrophy protein deficiency. Hum. Mol. Genet. 14, 1127-37.
Mostafaie, N., W. Rossmanith, H. Hombauer, T. Dechat, T. Raffelsberger, K. Bauer, B. Worofka, E. Kittl, J. Hofmann, M. Hejtman, W. Kirchmeyr, W. Schreiber, S. Weissgram, S. Jungwirth, P. Fischer, R. Bittner, and K. Huber (2004). Mitochondrial genotype and risk for Alzheimer's disease: cross-sectional data from the Vienna-Transdanube-Aging "VITA" study. J. Neural Transm. 111, 1155-65.
Vejda, S., N. Erlach, B. Peter, C. Drucker, W. Rossmanith, J. Pohl, R. Schulte-Hermann, and M. Grusch (2003). Expression of activins C and E induces apoptosis in human and rat hepatoma cells. Carcinogenesis 24, 1801-9.
Rossmanith, W., T. Raffelsberger, J. Roka, B. Kornek, M. Feucht, and R. E. Bittner (2003). The expanding mutational spectrum of MERRF: substitution G8361A in the mitochondrial tRNA^Lys gene. Ann. Neurol. 54, 820-3.
Chabicovsky, M., H. Niederstätter, R. Thaler, E. Hödl, W. Parson, W. Rossmanith, and R. Dallinger (2003). Localization and quantification of Cd- and Cu-specific metallothionein isoform mRNA in cells and organs of the terrestrial gastropod Helix pomatia. Toxicol. Appl. Pharmacol. 190, 25-36.
Chabicovsky, M., K. Herkner, and W. Rossmanith (2003). Overexpression of activin βC or activin βE in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells. Endocrinology 144, 3497-504.
Vejda, S., M. Cranfield, B. Peter, S. L. Mellor, N. Groome, R. Schulte-Hermann, and W. Rossmanith (2002). Expression and dimerization of the rat activin subunits βC and βE: evidence for the formation of novel activin dimers. J. Mol. Endocrinol. 28, 137-48.
Schulte-Hermann, R., W. Bursch, B. Grasl-Kraupp, W. Mikulits, J. Gotzmann, S. Vejda, W. Rossmanith, and W. Parzefall (2002). Apoptotic cytokines as regulators of anti-oncogenic responses and hepatocellular carcinoma growth. In: Immunology and the Liver. R. Moreno-Otero, A. Albillos, and C. Garcia-Monzón, eds. (Accion Medica, Madrid). pp. 281-90.
Schulte-Hermann, R., W. Bursch, J. Gotzmann, B. Grasl-Kraupp, W. Mikulits, W. Parzefall, W. Rossmanith, and S. Vejda (2002). TGF-β-induced liver cell apoptosis. In: Cytokines in Liver Injury and Repair. A. M. Gressner, P. C. Heinrich, and S. Matern, eds. (Kluver Academic Publishers, Lancaster). pp. 31-43.
Egerbacher, M., M. Helmreich, W. Rossmanith, and G. Haeusler (2002). Estrogen receptor-alpha and estrogen receptor-beta are present in the human growth plate in childhood and adolescence, in identical distribution. Horm. Res. 58, 99-103.
Rossmanith, W., M. Chabicovsky, K. Herkner, and R. Schulte-Hermann (2002). Cellular gene dose and kinetics of gene expression in mouse livers transfected by high-volume tail-vein injection of naked DNA. DNA Cell Biol. 21, 847-53.
Rossmanith, W., M. Chabicovsky, B. Grasl-Kraupp, B. Peter, E. Schausberger, and R. Schulte-Hermann (2002). Follistatin overexpression in rodent liver tumors: A possible mechanism to overcome activin growth control. Mol. Carcinog. 35, 1-5.
Huber, W. W., G. Scharf, W. Rossmanith, S. Prustomersky, B. Grasl-Kraupp, B. Peter, R. J. Turesky, and R. Schulte-Hermann (2002). The coffee components kahweol and cafestol induce γ-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat. Arch. Toxicol. 75, 685-94.
Grasl-Kraupp, B., E. Schausberger, K. Hufnagl, C. Gerner, A. Low-Baselli, W. Rossmanith, W. Parzefall, and R. Schulte-Hermann (2002). A novel mechanism for mitogenic signaling via pro-transforming growth factor α within hepatocyte nuclei. Hepatology 35, 1372-80.
Rossmanith, W., and T. Potuschak (2001). Difference between mitochondrial RNase P and nuclear RNase P. Mol. Cell. Biol. 21, 8236-7.
Raffelsberger, T., W. Rossmanith, H. Thaller-Antlanger, and R. E. Bittner (2001). CPEO associated with a single nucleotide deletion in the mitochondrial tRNA^Tyr gene. Neurology 57, 2298-301.
Rossmanith, W., and R. Schulte-Hermann (2001). Biology of transforming growth factor β in hepatocarcinogenesis. Microsc. Res. Tech. 52, 430-6.
Chabicovsky, M., K. Staniek, W. Rossmanith, W. Bursch, H. Nohl, and R. Schulte-Hermann (2001). Hepatocarcinogenesis in the context of strain differences in energy metabolism between inbred strains of mice (C57BL/6J and C3H/He). Adv. Exp. Med. Biol. 500, 607-11.
Wastl, U. M., W. Rossmanith, M. A. Lang, A. M. Camus-Randon, B. Grasl-Kraupp, W. Bursch, and R. Schulte-Hermann (1998). Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions. Mol. Carcinog. 22, 229-34.
Schulte-Hermann, R., A. Löw-Baselli, K. Hufnagl, L. Müllauer, W. Rossmanith, A. Wagner, B. Ruttkay-Nedecky, W. Bursch, W. Parzefall, and B. Grasl-Kraupp (1998). The role of apoptosis in hepatocarcinogenesis. In: Normal and malignant liver cell growth. W. E. Fleig, ed. (Kluwer Academic Press, Dordrecht). pp. 128-35.
Schulte-Hermann, R., K. Hufnagl, A. Löw-Baselli, W. Rossmanith, A. Wagner, B. Ruttkay-Nedecky, W. Bursch, L. Müllauer, W. Parzefall, and B. Grasl-Kraupp (1998). Apoptosis and hepatocarcinogenesis. Digestion 59 (Suppl. 2), 64-5.
Rossmanith, W., and R. M. Karwan (1998). Impairment of tRNA processing by point mutations in mitochondrial tRNA^Leu(UUR) associated with mitochondrial diseases. FEBS Lett. 433, 269-74.
Rossmanith, W., and R. M. Karwan (1998). Characterization of human mitochondrial RNase P: novel aspects in tRNA processing. Biochem. Biophys. Res. Commun. 247, 234-41.
Grasl-Kraupp, B., W. Rossmanith, B. RuttkayNedecky, L. Müllauer, B. Kammerer, W. Bursch, and R. Schulte-Hermann (1998). Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia. Hepatology 28, 717-26.
Rossmanith, W., E. Bettinger, C. Cerni, and R. M. Karwan (1997). Expression of mouse RNase MRP RNA in human embryonic kidney 293 cells. Mol. Biol. Rep. 24, 221-30.
Rossmanith, W. (1997). Processing of human mitochondrial tRNA^Ser(AGY): a novel pathway in tRNA biosynthesis. J. Mol. Biol. 265, 365-71.
Tullo, A., W. Rossmanith, E. M. Imre, E. Sbisà, C. Saccone, and R. M. Karwan (1995). RNase mitochondrial RNA processing cleaves RNA from the rat mitochondrial displacement loop at the origin of heavy-strand DNA replication. Eur. J. Biochem. 227, 657-62.
Rossmanith, W., A. Tullo, T. Potuschak, R. Karwan, and E. Sbisà (1995). Human mitochondrial tRNA processing. J. Biol. Chem. 270, 12885-91.
Rossmanith, W., A. Tullo, E.-M. Imre, C. Saccone, E. Sbisà, and R. Karwan (1995). Nuclear-mitochondrial coevolution of RNA processing enzymes and cellular function. In: Progress in Cell Research. Vol. 5. F. Palmieri, S. Papa, C. Saccone, and M. N. Gadaleta, eds. (Elsevier Science B.V., Amsterdam). pp. 143-7.
Potuschak, T., W. Rossmanith, and R. Karwan (1993). RNase MRP and RNase P share a common substrate. Nucleic Acids Res. 21, 3239-43.
Rossmanith, W., and R. Karwan (1993). Definition of the Th/To ribonucleoprotein by RNase P and RNase MRP. Mol. Biol. Rep. 18, 29-35.

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