Alina Neunkirchner (IFI) was selected Bright Spark at the ECI 2015
At the 4th European Congress of Immunology, Mag. Dr. Alina Neunkirchner from the Division of Immunology & Immunohematology (Institute of Immunology) was selected as one of the 24 Bright Sparks, out of the 2786 abstracts submitted.
In her presentation „Interleukin-2/anti-interleukin-2 antibody complexes expand T regulatory cells which protect against allergen-induced airway hyperreactivity“, Alina Neunkirchner introduced a new animal model for allergy research, double transgenic mice expressing a human T-cell-receptor and MHC, presenting and recognizing the immunodominant peptide of the major mugwort pollen allergen, Art v 1.
In this study, the increased production of regulatory T cells in vivo is achieved by the administration of the T-cell growth factor IL-2 in combination with an anti-IL-2 antibody. Expansion of regulatory T-cells before sensitization prevented development of allergen-induced airway hyperreactivity and reduced Art v 1-specific serum IgE.
Furthermore, similar effects were observed in a therapeutic setting. Taken together, these data give first insights into novel strategies for the prevention and therapy of allergic diseases.
From 2786 submitted abstracts for the 24 workshops of the European Congress of Immunology, the best ones were chosen by the reviewers and proposed as bright sparks with oral presentations.
These 24 presentations took place in 4 bright sparks workshops on 4 main scientific tracks of the congress: Adaptive Immunity, Innate Immunity, Immunological Diseases, Immunotherapy.
Each of the 24 bright sparks is awarded with 500 Euros.
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