Bridge Young Scientists project start
Assoc. Prof. Dr. Isabella Ellinger (Institute of Pathophysiology and Allergy Research, CePII, MedUni Vienna) in collaboration with Assoc. Prof. Dr. Georg Dorffner (Section for Artificial Intelligence and Decision Support, MedUni Vienna) and Dr. Rupert Ecker (TissueGnostics, GmbH, Austria ) has started a 2-year Bridge – Young Scientists project entitled “Deep learning for improved nuclei segmentation and knowledge transfer methods in microscopic images”. From the total project costs (€ 300.000), € 240.000 are funded by the Austrian Research Promotion Agency (FFG).
Nuclei segmentation is considered as the fundamental step in quantitative microscopic image analysis. As manual segmentation, performed by experts, is a time-consuming, subjective and complex procedure, the need for automatic computerized methods to perform nuclei segmentation has emerged. While Deep Learning-based approaches are the state-of-the art solutions for image segmentation tasks, there are still two main unsolved issues.
The first issue is the instance segmentation performance for challenging object cases, which needs to be significantly improved. The second issue is the generalization capability of these models. In this project, senior and young researchers aim to address both issues. In particular, for the first issue, our technical goal is to propose a novel DL-based approach for improved nuclei segmentation. For the second issue, we plan to improve the generalization capacity of the models by three different Deep Learning-based knowledge transfer methods including deep model adaption, deep style transfer for color normalization and multi-modal staining fusion for artificial ground truth generation.
Currently, two young researchers are involved in the project: Dr. Amirreza Mahbod (Post-Doc) and B.Sc. Benjamin Balcher (Master student).
Our project on FFG:
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