Dominik Filipp, PhD: "Enteric defensins, thymus and microbiota: essential players of intestinal autoimmunity"

Friday, May 22, 2015, 11.00 am, Vienna Competence Centre, Lazarettgasse 19, Vienna IX, seminar room, 1. floor

COLLOQUIUM IN PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGY

» Invitation

Dominik Filipp, PhD: Head of the Laboratory of Immunobiology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

Selected papers:

• Filipp, D., Alizadeh-Khiavi, D., Richardson, C., Palma, A., Paredes, N., Takeuchi, O., Akira, S., Julius, M. H. 2001. Soluble CD14 enriched in colostrum and milk induces B cells growth and differentiation. Proc. Natl. Acad. Sci. USA 98:603-608.
• Filipp, D., Zhang, J., Leung, B. L., Shaw, A., Levin, S. D., Veillette, A. and Julius, M. 2003. Regulation of Fyn Trough Translocation of Activated Lck into Lipid Rafts. J. Exp. Medicine 197: 1221.
• Filipp, D., Moemeni, B., Ferzoco, A., Kathirkamathamby, K., Zhang, J., Ballek, O., Davidson, D., Veillette, A., and Julius, M. 2008. Lck dependent Fyn activation requires c-terminus dependent targeting of kinase active Lck to lipid rafts. J. Biol. Chemistry 283:26409- 26422.
• Balounová, J., Vavrochová, M T., Benešová, M., Ballek, O., Kolář, M. and Filipp, D. Toll-like receptors expressed on embryonic macrophages couple inflammatory signals to iron metabolism during early ontogenesis. 2014. Eur J Immunol, 44(5): 1491-502.
• Ballek, O., Valecka, J., Manning, J., Filipp, D. The pool of preactivated Lck in the initiation of T-cell signaling: a critical re-evaluation of the Lck standby model. 2015. Immunol Cell Biol., 93: 384-395.
• Dobeš, J., Neuwirth, A., Dobešová, M., Vobořil, M., Balounová, J., Ballek, O., Lebl, J., Meloni, A., Krohn, K., Kluger, N., Ranki, A. and Filipp, D. Gastrointestinal autoimmunity associated with loss of central tolerance to enteric defensins. 2015. Gastroenterology. In press.

Host: Hannes Stockinger