Jan Dvořák, PhD: “Helminth proteases in host – parasite interactions”
Tuesday, June 27, 2017, 12:00, Hygiene Institute, Kinderspitalgasse 15, 1090 Vienna, Seminarraum 3, 2nd floor
COLLOQUIUM IN PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGY
Jan Dvořák
Czech University of Life Sciences, Prague and Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague
Education: Postdoctoral scholar (2005-2009), McKerrow laboratory, Sandler Center for Drug Discovery at the University of California San Francisco, USA (now UC San Diego www.cdipd.org); Ph.D. (2005) in parasitology, Charles University, Faculty of Science, Department of Parasitology, Prague.
Research interest: Proteolytic enzymes of parasitic organisms involved in the host-parasite interactions; Biology of schistosomes and other trematode species; Recombinant protein expression; Biochemistry.
Recent publications:
- Tallima H, Dvořák J., Kareem S., El Dahab M.A., Abdel Aziz N., John Dalton J.P, El Ridi R. Immunogenicity and Protective Capacity of a Trivalent Cysteine Peptidase-Based Schistosomiasis Vaccine. PLoS Neglected Tropical Diseases 2017 Mar; 11(3): e0005443.
- Sojka D, Hartmann D, Bartošová-Sojková P, Dvořák J. Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets. Trends Parasitology 2016 Sep;32(9):708-23.
- Smith D, Tikhonova IG, Jewhurst HL, Drysdale OC, Dvořák J, Robinson MW, Cwiklinski K, Dalton JP. Unexpected Activity of a Novel Kunitz-Type Inhibitor: Inhibition of Cysteine Proteases but not Serine Proteases. Journal of Biological Chemistry 2016 Sep 9;291(37):19220-34.
- Dvořák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mares M, Craik CS, Caffrey CR, O'Donoghue AJ. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie 2016; 122: 99-109. (Epub 2015 Sep 26).
- Fajtová P, Stefanic S, Hradílek M, Dvořák J, Vondrásek J, Jilková A, Ulrychová L, McKerrow JH, Caffrey CR, Mares M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: from Functional Analysis to Anti-schistosomal Inhibitors. PLoS Neglected Tropical Diseases. 2015; 9(6): e0003827.
- Dalton, JP, Dvořák J. Activating the cathepsin B1 of a parasite: a major route with alternative pathways? Structure 2014; 22 (12): 1696-8.
- Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartosová-Sojková P, Franta Z, Protasio AV, Opavsk. D, Vondrásek J, McKerrow JH, Mares M, Caffrey CR, Dvořák J. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Neglected Tropical Diseases. 2014; 8(3):e2766
Host: Irma Schabussova
zurück zu: CePII