Scope of the Gruber research group
The interaction of the skin with the environment is a major research topic of the Gruber research group. We investigate how the skin and its various cell types cope with intrinsic and extrinsic stressors and with aging. Special foci of our research are cellular senescence and the epilipidome (https://www.epilipid.net/). The research group is headquarter of the new Christian Doppler Laboratory on Skin Multimodal Imaging of Aging and Senescence -SKINMAGINE-.
This CDL investigates, with a multimodal analytical imaging approach, how cellular senescence and the urban exposome (pollution and ultraviolet radiation) affect the lipid- and energy metabolism, the cellular quality control and the communication of cutaneous cells, all in the tissue context. These aims are investigated in collaboration with the research groups of Markus Schosserer at the BOKU Wien and of Martina Marchetti-Deschmann at the TU Wien,together with our industry partner Chanel PB.
Another interest of our group is the generation and function of bioactive lipids in the sebaceous gland, which we study together with Daniel Töröcsik (Univ. Debrecen) https://www.researchgate.net/profile/Daniel-Toerocsik-2 in a FWF project.
Other recent research activities
Our group uncovered the dynamics of lipid homeostasis restoration after UV stress in keratinocytes (Narzt et al., Redox Biology 2019) https://www.ncbi.nlm.nih.gov/pubmed/30466060/. Using automated imaging of metabolic activity we found that human epidermal keratinocytes re-route their metabolism to produce reducing equivalents and building blocks for nucleotide synthesis (Kremslehner et al., Redox Biology 2020) https://pubmed.ncbi.nlm.nih.gov/32713735/. We found that senescent dermal fibroblasts display and secrete lysophospholipids and selected other members of the epilipidome, and that these lipids constitute part of their senescence associated secretory phenotype (SASP) (Narzt et al. Journal of Investigative Dermatology, 2021) https://pubmed.ncbi.nlm.nih.gov/33333126/. We found that autophagy is required to prevent premature senescence in murine preputial glands and could localize aberrant lipid distribution within the affected tissue (Rossiter et al., Autophagy 2021) https://pubmed.ncbi.nlm.nih.gov/34491140/.
Recent review articles
Find here our review article on the skin epilipidome in stress, aging and inflammation (Gruber et al., Front. Endocrinol. 2021) https://pubmed.ncbi.nlm.nih.gov/33551998/, on recent advances in cell aging and cellular senescence and their impact on skin biology and dermatology (Gruber et al., Exp. Gerontol. 2020) https://pubmed.ncbi.nlm.nih.gov/31794850/, on senolytics in skin aging and –regeneration (Pils et al., Mech. Ageing Dev. 2021) https://pubmed.ncbi.nlm.nih.gov/34678388/, on the impact of lipid oxidation and the epilipidome on dermatological research (Gruber et al., Free Rad. Biol. Med. 2019) https://pubmed.ncbi.nlm.nih.gov/31004751/ and on the role of autophagy in skin aging (Eckhart et al., Front. Cell. Dev. Biol. 2019) https://pubmed.ncbi.nlm.nih.gov/31417903/.
Full literature list Gruber group
Florian Gruber (Assoc. Prof. Mag. Dr.)
Michaela Sochorová (Postdoctoral Researcher)
Christopher Kremslehner (Ph.D. Student, MS)
Ionela-Mariana Nagelreiter (Lab Manager, MS (FH), collaboration with Center for Brain Research)
Christian Doppler Society, Herzfelder’sche Familienstiftung, FWF.