Scope of the Gruber research group
The interaction of the skin with the environment is a major research topic of the Gruber research group. We investigate how the skin and its various cell types cope with intrinsic and extrinsic stressors and with aging. A special focus of our research is on the role that lipids and their oxidation play in skin biology. The research group is the headquarter of the new Christian Doppler Laboratory on Skin Multimodal Imaging of Aging and Senescence -SKINMAGINE-.
This CDL investigates, with a multimodal analytical imaging approach, how cellular senescence and the urban exposome (pollution and ultraviolet radiation) affect the lipid- and energy metabolism, the cellular quality control and the communication of cutaneous cells, all in the tissue context. These aims are investigated in collaboration with the research groups of Markus Schosserer at the BOKU Wien and of Martina Marchetti-Deschmann at the TU Wien,together with our industry partner Chanel PB.
Other recent research activities
We uncovered that ultraviolet (UV) light oxidizes phospholipids (Gruber JBC 2007 https://www.ncbi.nlm.nih.gov/pubmed/17449870/) , and characterized the oxidized phospholipidome of skin fibroblasts after UV exposure (Gruber JLR 2012 https://www.ncbi.nlm.nih.gov/pubmed/22414483/) . Our group uncovered the dynamics of lipid homeostasis restoration after UV stress in keratinocytes (Narzt et al., Redox Biology 2019) https://www.ncbi.nlm.nih.gov/pubmed/30466060/. Using automated imaging of metabolic activity we found that human epidermal keratinocytes re-route their metabolism to produce reducing equivalents and building blocks for nucleotide synthesis (Kremslehner et al., Redox Biology 2020) https://pubmed.ncbi.nlm.nih.gov/32713735/. Our latest finding was that senescent dermal fibroblasts display and secrete lysophospholipids and selected other members of the epilipidome, and that these lipids constitute part of their senescence associated secretory phenotype (SASP) (Narzt et al. Journal of Investigative Dermatology, in press).
Recent review articles
Find here our review article on recent advances in cell aging and cellular senescence and their impact on skin biology and dermatology (Gruber et al., Exp. Gerontol. 2020) https://pubmed.ncbi.nlm.nih.gov/31794850/, on the impact of lipid oxidation and the epilipidome on dermatological research (Gruber et al., Free Rad. Biol. Med. 2019) https://pubmed.ncbi.nlm.nih.gov/31004751/ and on the role of autophagy in skin aging (Eckhart et al., Front. Cell. Dev. Biol. 2019) https://pubmed.ncbi.nlm.nih.gov/31417903/.
Full literature list Gruber group
Florian Gruber (Assoc. Prof. Mag. Dr.)
Michaela Sochorová (Postdoctoral Researcher)
Yiwen Yang (Ph.D. Student)
Christopher Kremslehner (Ph.D. Student, MS)
Ionela-Mariana Nagelreiter (Lab Manager, MS (FH), collaboration with Center for Brain Research)
Maja Mitrovic (MS Student)
Christian Doppler Society, Herzfelder’sche Familienstiftung.