Ghasem Ahangari, MT, PhD: “Analysis of expression changes of dopamine receptors’ genes and their pharmacogenetic effects on apoptosis as new perspective therapy of breast cancer”
Wednesday, December 16, 2015, 14:00, Vienna Competence Centre, Lazarettgasse 19, Vienna IX, seminar room, 1. floor
COLLOQUIUM IN PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGY
Ghasem Ahangari’s major research interest is the expression of genes upon the environmental interaction of an organism. Environmental factors disturbing the dialog between the neuro- and immune system result in imbalance or complex disorders.
He investigates the interaction between the immune and the neuropsychological system in disorders such as asthma, autoimmunity, cancer in individuals who had been exposed to air pollution. Particularly, he quantified changes in gene expression of neurotransmitter receptors on blood cells, in particular T cells. He expanded his research to include neuropsychological changes associated with stress factors.
As principal investigator of several grants he found effective changes of neurotransmitter receptors and other factors relevant to these receptors. Based on the changes of expression of these receptors in different diseases he targeted them via specific agonistic or antagonistic drugs. In addition, he successfully treated tumor cells (lung and breast cancer) with specific drugs to induce apoptosis.
- Pornour M., G. Ahangari et al. 2015. New prospective therapy of breast cancer based on selective dopamine receptor D2 agonist and antagonist effects on MCF-7 cell line. Recent Pat Anticancer Drug Discov. 2015;10(2):214-23
- Shikhpour M, G. Ahangari. 2013. A novel report of apoptosis in human lung carcinoma cells using selective agonist of D2-like dopamine receptors: a new approach for the treatment of human non-small cell lung cancer. International journal of Immunopathology and Pharmacology, 26, 2, 29-38
- Jafari M, G. Ahangari et al. 2013. Distorted expression of dopamine receptor genes in systemic lupus erythematosus. Immunobiology,218, 979-983
Host: Hannes Stockinger
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