Jan Dvořák, PhD: “Helminth proteases in host – parasite interactions”

Tuesday, June 27, 2017, 12:00, Hygiene Institute, Kinderspitalgasse 15, 1090 Vienna, Seminarraum 3, 2nd floor

COLLOQUIUM IN PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGY

» Invitation

Jan Dvořák

Czech University of Life Sciences, Prague and Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague

Education: Postdoctoral scholar (2005-2009), McKerrow laboratory, Sandler Center for Drug Discovery at the University of California San Francisco, USA (now UC San Diego www.cdipd.org); Ph.D. (2005) in parasitology, Charles University, Faculty of Science, Department of Parasitology, Prague.

Research interest: Proteolytic enzymes of parasitic organisms involved in the host-parasite interactions; Biology of schistosomes and other trematode species; Recombinant protein expression; Biochemistry.

Recent publications:

• Tallima H, Dvořák J., Kareem S., El Dahab M.A., Abdel Aziz N., John Dalton J.P, El Ridi R. Immunogenicity and Protective Capacity of a Trivalent Cysteine Peptidase-Based Schistosomiasis Vaccine. PLoS Neglected Tropical Diseases 2017 Mar; 11(3): e0005443.
• Sojka D, Hartmann D, Bartošová-Sojková P, Dvořák J. Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets. Trends Parasitology 2016 Sep;32(9):708-23.
• Smith D, Tikhonova IG, Jewhurst HL, Drysdale OC, Dvořák J, Robinson MW, Cwiklinski K, Dalton JP. Unexpected Activity of a Novel Kunitz-Type Inhibitor: Inhibition of Cysteine Proteases but not Serine Proteases. Journal of Biological Chemistry 2016 Sep 9;291(37):19220-34.
• Dvořák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mares M, Craik CS, Caffrey CR, O'Donoghue AJ. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie 2016; 122: 99-109. (Epub 2015 Sep 26).
• Fajtová P, Stefanic S, Hradílek M, Dvořák J, Vondrásek J, Jilková A, Ulrychová L, McKerrow JH, Caffrey CR, Mares M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: from Functional Analysis to Anti-schistosomal Inhibitors. PLoS Neglected Tropical Diseases. 2015; 9(6): e0003827.
• Dalton, JP, Dvořák J. Activating the cathepsin B1 of a parasite: a major route with alternative pathways? Structure 2014; 22 (12): 1696-8.
• Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartosová-Sojková P, Franta Z, Protasio AV, Opavsk. D, Vondrásek J, McKerrow JH, Mares M, Caffrey CR, Dvořák J. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Neglected Tropical Diseases. 2014; 8(3):e2766  

Host: Irma Schabussova