Passive smoking: Acrolein inhibits immune defense ans thereby favours tumor growth
In Austria alone, two or three people a day die as a result of passive smoking, for pets the numbers are obscure. Acrolein, a compound in side stream smoke, was identified for the first time by Franziska Roth-Walter (IPA) et al. as one of the main causes of failure of the immune defence to tumours due to passive smoking: It stimulates T-regulatory cells via the Arylhydrocarbon-Receptor.
Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure. Franziska Roth-Walter, Cornelia Bergmayr, Sarah Meitz, Stefan Buchleitner, Caroline Stremnitzer, Judit Fazekas , Anna Moskovskich , Mario A. Müller , Georg A. Roth, Krisztina Manzano-Szalai, Zdenek Dvorak , Alina Neunkirchner & Erika Jensen-Jarolim. Scientific Reports 7:45067 | DOI: 10.1038/srep45067
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